Gene Information

Name : guaA (PMM0037)
Accession : NP_892158.1
Strain : Prochlorococcus marinus CCMP1986
Genome accession: NC_005072
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 34925 - 36511 bp
Length : 1587 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAGTAAAAAATTACTAAAAAAAGAGAGAGATCCCTCAATATTAATTCTAGATTTTGGATCTCAATATTCTGAATTAAT
TGCAAGGAGAATAAGAGAAGCAGATGTATTTTCTCTTGTAGTAAGTAACTTTACCTCTGTCAAGGAGATTCAGGATATAA
ATCCAAAAGGGATTATATTAAGTGGTGGCCCAAGTTCTGTTTATGAAGATAATGCACCTAAATGTGATGCAAAGATTTTT
GATTTAGGTATTCCAATTTTGGGTATATGTTATGGAATGCAATTAATGGTTAAAGAATTAGGAGGTGAAGTTACCCCAGC
AATTAATAAAGCTGAATATGGCAGAGCACCAATAAATATTGATTGCGAAAGTGATTTGCTATCTAATGTCCAAGATAAAT
CTATTATGTGGATGAGTCATGGAGATTCTATAAATAACTTGCCTGAAGGATTTATTAAGATTTCTCATACAGAAAATACC
CTGCATGCTGCAATATCAAACAAACAAAAGAAATTATTTGGTGTTCAATTTCATCCTGAAGTTATTCATTCAGAATTCGG
AATGACGGTTATTAAAAACTTTGTTTATTCTATTGCTAAATGTAAGGCCGATTGGACTACTGAAACTTTTTTAGAGGAAA
CAATTCCAAGAATTAAGCAACAAGTAGGTGATAAGAGAGTTTTACTTGCTCTTTCTGGCGGCGTAGATTCATCAACCCTC
GCTTTTCTTCTCAATAAAGCTATTGGTAAAAAGCTTACTTGTATGTTTATTGATCAAGGCTTTATGAGAAAAGGTGAACC
TGAATTTTTAATGGAATTTTTTGATAAAAAATTTCATATAAAAGTTGAATATATTAACGCTAGGGAAAGATTTATTGATA
AATTAAATGGAATAACTGACCCAGAAGAAAAACGCAAGATTATTGGTAGAGAATTTATTAGAGTTTTTGAAGAGGAGAGT
AATAGATTAGGTCCTTTCCAATATTTGGCTCAAGGTACTCTTTACCCAGACGTTATTGAGAGTGCTGGAACGAATTTAGA
TCCAAAGACTGGTGAGCGAATTGCAGTAAAAATAAAAAGTCATCATAACGTAGGCGGTTTGCCAAAAGATTTACAATTTA
AATTAGTTGAACCATTAAGAAAACTTTTTAAAGATGAAGTAAGAAAGGTTGGAGGTGCTTTAGGATTGCCAGATGAAATC
ATAAAAAGACATCCATTTCCTGGCCCTGGCTTAGCAATAAGAATTTTAGGTGATGTTTCTCATGAAAAACTAAACTGTTT
GAGAGATGCAGACTGGATAGTAAGAGATGAAATAAAAAAAGCAGGTCTTTATAATGATATATGGCAAGCATTTGCAGTTC
TTTTACCTGTTAAGACTGTCGGTGTAATGGGAGATAAACGGACTTATGCTTGGCCAATAGTTTTACGATGCGTATCAAGC
GAAGATGGGATGACGGCTGATTGGTCGAGAATTCCTTATGAAACCTTAGAGAGAATTTCTAATAGAATCGTTAATGAAGT
AGAGCAGGTTAATAGGGTTGTTTTCGATATTACTAGTAAGCCTCCAGGAACAATTGAGTGGGAATAA

Protein sequence :
MSKKLLKKERDPSILILDFGSQYSELIARRIREADVFSLVVSNFTSVKEIQDINPKGIILSGGPSSVYEDNAPKCDAKIF
DLGIPILGICYGMQLMVKELGGEVTPAINKAEYGRAPINIDCESDLLSNVQDKSIMWMSHGDSINNLPEGFIKISHTENT
LHAAISNKQKKLFGVQFHPEVIHSEFGMTVIKNFVYSIAKCKADWTTETFLEETIPRIKQQVGDKRVLLALSGGVDSSTL
AFLLNKAIGKKLTCMFIDQGFMRKGEPEFLMEFFDKKFHIKVEYINARERFIDKLNGITDPEEKRKIIGREFIRVFEEES
NRLGPFQYLAQGTLYPDVIESAGTNLDPKTGERIAVKIKSHHNVGGLPKDLQFKLVEPLRKLFKDEVRKVGGALGLPDEI
IKRHPFPGPGLAIRILGDVSHEKLNCLRDADWIVRDEIKKAGLYNDIWQAFAVLLPVKTVGVMGDKRTYAWPIVLRCVSS
EDGMTADWSRIPYETLERISNRIVNEVEQVNRVVFDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 5e-141 54
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 3e-141 54
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-141 54
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-131 51