Gene Information

Name : guaA (SYNW0047)
Accession : NP_896142.1
Strain : Synechococcus sp. WH 8102
Genome accession: NC_005070
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 43692 - 45278 bp
Length : 1587 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGTCCCAGTCTTCGTCCGACGGTCAGCGTCAGCCGGCCATCGTCATCCTTGATTTCGGCTCCCAGTACTCGGAGCTGAT
CGCCCGGCGCGTGCGCGAAACCGAGGTGTTTTCGGTGGTGCTCGGTTACAGCACCTCAGCGGAGGAGTTGCGGGCGATGC
AGCCGAAGGGGATCGTCCTCAGCGGCGGTCCCAGTTCGGTGTACGCCGAGCACGCGCCCCTCTGTGATCCGGCGATCTGG
GAGCTGGGCATCCCGGTGCTGGGGGTCTGTTACGGCATGCAGCTGATGGTGCAGCAGCTGGGAGGTGTGGTGGAAGCTGC
CAGCGGCAAGGCCGAATACGGCAAGGCACCGCTGGAGGTGGATGATCCCACCGATCTGCTCACCAACGTCACCGGTGGAT
CCACGATGTGGATGAGCCATGGCGACTCGGTGAAGGCCCTGCCCGAGGGATTTGTTCGCCTGGCGCACACCGCCAACACC
CCGGAAGCCGCGGTTGCCCATCTGCAGCGTCGCCTCTACGGCGTCCAGTTCCACCCCGAGGTGGTGCATTCCACCTGCGG
CATGGCTCTGATCCGCAATTTCGTATACCACATCTGTGGCTGTGAGCCGGACTGGACCACCAGCGCCTTCATCGATGAGG
CCGTCGCGGTGGTGCGGGAGCAGGTGGGCGAGAAGCGGGTTCTGCTGGCCCTGTCCGGTGGAGTCGATTCCTCAACCCTC
GCTTTCCTGTTGAAGAAAGCGATTGGTGATCAGCTCACCTGCATGTTCATCGACCAGGGCTTCATGCGGAAAGGGGAGCC
GGAGTTCCTGATGGACTTCTTCGATCGGAAGTTCAATATTCATGTGGAGTACATCAATGCCCGCCAACGCTTCATCAGCA
AGCTGAAGGGGATCACCGATCCGGAGGAGAAGCGCAAGATCATCGGCACGGAATTCATCCGTGTGTTCGAAGAGGAGAGC
AAGCGCCTCGGACCGTTCGACTACCTGGCGCAAGGAACCTTGTACCCGGATGTGATCGAAAGCGCCGGTACCAATGTCGA
TCCCAAGACCGGTGAGCGGGTGGCGGTGAAGATCAAGAGCCACCACAACGTGGGCGGTTTGCCCAAGGATCTGCAGTTCA
AGTTGGTGGAACCGTTGCGCAAGTTGTTCAAGGACGAGGTGCGCAAGGTGGGGCGTGCCCTGGGCCTGCCGGAGGAGATC
GTCCGCCGCCATCCCTTCCCCGGCCCTGGCTTGGCGATCCGCATCCTGGGGGAGGTCACCGACGAGAAGCTCAACTGCCT
GCGGGATGCCGACCTGATCGTGCGGGAGGAAATCCGCGAGGCCGGGCTCTATCACGAGATCTGGCAGGCCTTCGCCGTGT
TGCTGCCCGTTCGCTCAGTCGGGGTGATGGGGGACAAGCGGACCTATGCCTGGCCGATTGTGCTGCGCTGCGTCTCCAGC
GAAGACGGCATGACCGCCGATTGGTCACGGTTGCCTTACGACCTGATGGAGACCATCTCCAATCGCATCGTGAATGAGGT
GAAGGGGGTGAACCGGGTGGTGCTGGATATCACCAGCAAACCGCCGGGCACGATCGAGTGGGAATAG

Protein sequence :
MSQSSSDGQRQPAIVILDFGSQYSELIARRVRETEVFSVVLGYSTSAEELRAMQPKGIVLSGGPSSVYAEHAPLCDPAIW
ELGIPVLGVCYGMQLMVQQLGGVVEAASGKAEYGKAPLEVDDPTDLLTNVTGGSTMWMSHGDSVKALPEGFVRLAHTANT
PEAAVAHLQRRLYGVQFHPEVVHSTCGMALIRNFVYHICGCEPDWTTSAFIDEAVAVVREQVGEKRVLLALSGGVDSSTL
AFLLKKAIGDQLTCMFIDQGFMRKGEPEFLMDFFDRKFNIHVEYINARQRFISKLKGITDPEEKRKIIGTEFIRVFEEES
KRLGPFDYLAQGTLYPDVIESAGTNVDPKTGERVAVKIKSHHNVGGLPKDLQFKLVEPLRKLFKDEVRKVGRALGLPEEI
VRRHPFPGPGLAIRILGEVTDEKLNCLRDADLIVREEIREAGLYHEIWQAFAVLLPVRSVGVMGDKRTYAWPIVLRCVSS
EDGMTADWSRLPYDLMETISNRIVNEVKGVNRVVLDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-134 54
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 3e-141 54
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 4e-141 54
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-141 54