Gene Information

Name : guaA (Bfl527)
Accession : NP_878807.1
Strain : Candidatus Blochmannia floridanus
Genome accession: NC_005061
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 585411 - 586991 bp
Length : 1581 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAAACAATGTACTAGACAGTGTATTTTGATTATAGATTTTGGATCTCAGTATACGCAATTATTATTAAGACGAATTCG
AGAATTAGGAATATATGCTAAAGTATGCGATTGGAATATTAGTCAAGATCTATTGGTTAGTTTAAATCCTAATGGGATTA
TTTTTTCTGGAGGTCCAGATAGTGTAACGAATAAACACTCGTCAAGTATATCAAAAGTCGTTTTCAAAATTGGTGTTCCA
ATATTAGGAATTTGTTATGGAATGCAAATTTTGGTTAGTCAATGCGGAGGGAATATCCGATCTGTATCTAATAAAGGAGA
ATTTGGTTATGCTCAGGTTGAAATACTATCTCAAAAAAATACATTAATTGGTAATCTTTATGATTATATCAATGATCAAG
GTCATTGTGTATTAGAGGTATGGATGAGTCATAAAGATATAGTGGAAACTATGCCACAAGGCTTTACTGTTATTGGGATT
ACTGAAAATCAGCAAATTGCTATTATAATCAATGAAAAATGTCGTTGGTATGGTATACAGTTTCATCCAGAGGTTACGCA
TACTAAAAAAGGAAAAGATATTTTAAAAAGGTTTGCTGTAGATATTTGCAGATGTGAGGTTACATGGAAACCTGTATATA
TTGTTAAAAATATTATTAAAACTATTAAAAAGGTAGTAGGTCAAGATAGAGTAGTTCTTGCTTTTTCTGGAGGAATTGAT
TCTTTGGTGACGGCTTTGTTATTAAAATATGCAATTAATCATGAACAGTTTGTTTGTGTATTTGTAAATAATGGATTATT
ATGTTGTAATGAAATTAATCGAATTAGTAATTTTTGTAAAAAATATCAAGATTTAAATATTATTCATTTATCAGAAGAGA
AGCGTTTTTTAAGTGCTTTAACTGGTGTTATTGATCCAGAAGAAAAAAGAAAAATAATAGGGAAAATATTTGTAGAAATA
TTTCAAGCGCAAATTAGTCAGTTAAAAAATATTAAATGGTTGGCTCAAGGTACTATATATTCAGATGTTATTGAATCTGG
AATGTCATGTGCTTCTGCTAATATAATTAAATCGCATCATAATGTTGGAGGATTTCCAAGTTCTGTTAATATTCAGTTGT
TAGAGCCTATAAAAGATTTATTTAAGGATGAAGTTCGTAATATTGGGTTGTATTTAGGATTACCGTTAAATGTAGTCAAT
CAATATCCATGTCCAGGTCCTGGAATGGCTATTAGAATATTAGGAGAAGTACGGGAAGAATATTGTAATATATTACGAAG
AGTTGATTATATTTTTATGGAAGAGTTGAATAAATCAGATTTGTATAATACTGTTGATCAAGCATTTGCAGTGTTTTTGC
CAGTTCAATCAGTAGGGGTACAAGGAGATCAACGTAAATATAAATGGGTTATTGTGTTACGAGCGATAGAAACTGAAGAT
TTTATGACGGCACAATGGGTTCGGCTTCCATATACTTTTTTAAATAAAGTATCTAATCGTATTGTTAATGAGGTTGAGGA
AGTGTCAAGAGTGGTTTATGATATTTCTTGTAAACCTCCAGCTACAATTGAATGGGAGTAA

Protein sequence :
MKQCTRQCILIIDFGSQYTQLLLRRIRELGIYAKVCDWNISQDLLVSLNPNGIIFSGGPDSVTNKHSSSISKVVFKIGVP
ILGICYGMQILVSQCGGNIRSVSNKGEFGYAQVEILSQKNTLIGNLYDYINDQGHCVLEVWMSHKDIVETMPQGFTVIGI
TENQQIAIIINEKCRWYGIQFHPEVTHTKKGKDILKRFAVDICRCEVTWKPVYIVKNIIKTIKKVVGQDRVVLAFSGGID
SLVTALLLKYAINHEQFVCVFVNNGLLCCNEINRISNFCKKYQDLNIIHLSEEKRFLSALTGVIDPEEKRKIIGKIFVEI
FQAQISQLKNIKWLAQGTIYSDVIESGMSCASANIIKSHHNVGGFPSSVNIQLLEPIKDLFKDEVRNIGLYLGLPLNVVN
QYPCPGPGMAIRILGEVREEYCNILRRVDYIFMEELNKSDLYNTVDQAFAVFLPVQSVGVQGDQRKYKWVIVLRAIETED
FMTAQWVRLPYTFLNKVSNRIVNEVEEVSRVVYDISCKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-97 45
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 8e-98 45
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 7e-98 45
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-90 42