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Name : ureB (HH0408) Accession : NP_859939.1 Strain : Helicobacter hepaticus ATCC 51449 Genome accession: NC_004917 Putative virulence/resistance : Virulence Product : urease subunit beta Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 392628 - 394337 bp Length : 1710 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureA(alph DNA sequence : ATGATTAAGATTTCAAGAAAACAATATGCCTCTATGTATGGACCAACCACAGGTGATAAAGTGCGCTTAGGCGATACAAA CTTATTTGCAGAAATTGAAAAAGATTATACCCTTTATGGTGAAGAGATTAAATTTGGCGGAGGAAAAACTATCCGCGATG GTATGGCACAAAGCGCAAGCACTTATACAAATGAGCTTGATGCAGTCATCACAAATGCAATGATTATTGATTATACAGGG ATTTACAAAGCTGATATTGGCATTAAGGGTGGAAAAATCGTAGGCATTGGTAAAGCGGGAAATCCAGACACGCAAGATAG TGTAAATGAGGCAATGGTTGTAGGTGCTGCAACAGAAGTTATAGCAGGAGAAGGACAAATTATTACAGCGGGTGGAATTG ATACACATATTCACTTTATCTCTCCTACACAAATCCCAACTGCACTTTATAGCGGTGTAACAACGATGATTGGTGGAGGC ACAGGACCTGCAGCAGGCACAAACGCTACTACCTGCACACCCGGAAAATGGAATATGCACCAAATGTTGCGTGCTGCTGA AAGCTATGCTATGAATCTAGGATTTTTTGGCAAAGGCAATAGCTCTAATGAAGAAGGATTAGAAGAGCAAATTAAAGCTG GAGCATTGGGATTAAAGGTTCACGAAGATTGGGGTTCTACTCCTGCTGCAATTAACCACGCTCTCAATGTTGCCCAAAAA TATGATGTGCAAGTAGCTATTCACACAGATACACTCAATGAAGCAGGCTGTGTTGAAGACACAATGAAAGCAATTGATGG CAGAACTATCCATACATTCCATACAGAAGGTGCTGGTGGAGGACACGCTCCAGATATTATTAAAGCTGCAGGAGAACCAA ATATTCTCCCTGCTTCTACAAATCCCACCATTCCATTTACAAAAAATACAGCTGATGAGCATTTGGATATGCTTATGGTA TGTCATCACTTAGATAAAAAAATTAAAGAAGATGTGGCTTTTGCTGATAGCAGAATCCGCCCAGAAACCATCGCCGCAGA AGATACGCTTCACGATATGGGGATTTTCTCAATCACAAGCTCAGATTCTCAAGCTATGGGGAGAGTGGGTGAAGTCATCA CAAGGACTTGGCAAACTGCCGATAAATGCAAAAATGAATTTGGAGCCTTAAAAGAAGAATGCGGCGAAAATGATAACTTT AGAATCAAAAGATATATTTCAAAATACACTATCAATCCAGCTATTGCTCACGGGATTTCAGAATATGTAGGTTCTGTTGA AGTGGGTAAATTTGCTGATTTAGTTCTTTGGAAACCAAGTATGTTTGGCATAAAGCCAGAGATGATACTCAAAAATGGAA TGATTGTAGCAGCAAAAATAGGGGATTCTAATGCTTCTATTCCTACTCCTGAACCTGTCGTATATGCCCCAATGTTTGGC AGCTATGGCAAAGCAAAGTATAATTGTGCGATCACTTTTGTCTCAAAAATTGCCTATGATTGTCATATCAAAGAGGAACT TGGGCTTGAAAGAATACTTTTGCCTGTAAAAAATTGTCGCAATATTACAAAAAAAGATATGAAATTTAATGATGTCATCA CACCCATTGAAGTGAATCCAGAAACTTATGAAGTAAGAGTAAATAATACAAAAATTACTTCTAAGCCTGTTGAAAAGGTA TCTTTAGGGCAACTTTATTGTTTATTTTAA Protein sequence : MIKISRKQYASMYGPTTGDKVRLGDTNLFAEIEKDYTLYGEEIKFGGGKTIRDGMAQSASTYTNELDAVITNAMIIDYTG IYKADIGIKGGKIVGIGKAGNPDTQDSVNEAMVVGAATEVIAGEGQIITAGGIDTHIHFISPTQIPTALYSGVTTMIGGG TGPAAGTNATTCTPGKWNMHQMLRAAESYAMNLGFFGKGNSSNEEGLEEQIKAGALGLKVHEDWGSTPAAINHALNVAQK YDVQVAIHTDTLNEAGCVEDTMKAIDGRTIHTFHTEGAGGGHAPDIIKAAGEPNILPASTNPTIPFTKNTADEHLDMLMV CHHLDKKIKEDVAFADSRIRPETIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKCKNEFGALKEECGENDNF RIKRYISKYTINPAIAHGISEYVGSVEVGKFADLVLWKPSMFGIKPEMILKNGMIVAAKIGDSNASIPTPEPVVYAPMFG SYGKAKYNCAITFVSKIAYDCHIKEELGLERILLPVKNCRNITKKDMKFNDVITPIEVNPETYEVRVNNTKITSKPVEKV SLGQLYCLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 7e-150 | 63 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 7e-150 | 63 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 4e-142 | 59 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 4e-142 | 59 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 4e-142 | 59 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 4e-142 | 59 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureB | NP_859939.1 | urease subunit beta | VFG0270 | Protein | 0.0 | 77 |
