Gene Information

Name : clpA (HH0109)
Accession : NP_859640.1
Strain : Helicobacter hepaticus ATCC 51449
Genome accession: NC_004917
Putative virulence/resistance : Virulence
Product : ATP-dependent Clp protease ClpA
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : 3.1.21.-
Position : 106821 - 109400 bp
Length : 2580 bp
Strand : -
Note : ATP-binding subunit

DNA sequence :
ATGAATTTATTTGAAAAATTAACAAACCAAATGAAAGAAACGCTTGATAGTGCAGCTTCGCTTGCCTTACATTCAAGTAA
TCAAGAAATTTCTCTTGCACATATATATTGGGCGCTTTTAAGTAATCATCAAAGTGTGCTCAATCAGGCTTTGAATAAAA
TGAATATTGATAAAACTGCGCTTGAGCTTCAAGCGCGCAGTGAAGTAGATAAACTTCCCAAAAGCTCACAGGTGCAAAAA
GAGAATCTAAGTATCAGTAAAGAGCTTTCAAGTGCGCTTAATCTTGCTCAAGGCGAGGCAATTAAGAATGGTGATAGTTT
TATTGCAGTAGATATGTTTTTAATCGCTAATCTTAAAGAGAGCACTTTTGTAGCTATATTTAAGCCTCTTGTGGATATTG
CAGAGTTTAAAAAGACATTACTAAGTCTAAGAGGGGAGAGCAAGATAGAATCTCAAAGTGGTGATGATAATTTGGAATCT
TTAAGTAAATTTGGCATTGATTTAACCCAAAAAGCATTAGAAAACACTCTTGACCCTGTTATAGGGCGCGATGATGAGAT
TAATGCAATGATGCAGATTCTCATACGTAAAAGTAAAAATAATCCTATTTTATTGGGAGAGCCAGGTGTGGGAAAAACTG
CTGTGGTAGAGGGTTTAGCACAGCGAATTGTGGCAAAGGCTGTGCCTACAAGTTTGCAGAATAAAAAGCTCATTGCCCTT
GATATGAGCGCACTTATTGCTGGAGCAAAATATCGCGGAGAGTTTGAAGAACGACTTAAAAATGTTGTTGATGAAGTGAA
AAAAGCTGGAAATATTATTTTATTTATTGATGAGATTCACACTATTGTGGGTGCTGGGGCAAGTGAAGGGAGTATGGACG
CAGCAAATATACTTAAACCTGCTCTTGCACGAGGGGAGCTTCACACTATTGGTGCAACTACGTTAAAGGAGTATCGCAAG
TATTTTGAAAAAGATGCTGCACTTACACGGCGATTTCAGCCTATAAATGTCAATGAACCAAGCATTAATGAGGCATTACA
AATTTTGCGAGGGATTAAGCCAAATTTAGAGGCGCACCATAATGTCAATATTACAGATGCTGCACTTGTAGCAGCAGCCA
AGCTTTCAAGTCGATATATTACCGATAGGTTTTTGCCTGATAAGGCGATTGATTTGATTGATGAGGCAGCAGCAGAGCTG
AAGATGCAAATAGAATCTGAACCCTTAGAGCTAAGCAAGATTAAAAAACACATTGCCAATCTTGAAGTTGAAAAACAAGC
ACTCAATATGGAAAAAACAAATGTCAATGAGGCGCGTGTGCTAGAGATTGATAAGGAATTGGAGAATTTGCGTGAGGAAA
AAATGAGCTTAGAGGGCAAATTTGAGCAAGAAAAGAGCGTTTTTACGCGTATTGCTACAATAAAAGCGGAGCTTGATAGC
CTAAAAAGAGAATCTGAACTTGCTAAACGAAGTGGAGATTATAACAAAGCGGCTGAAATTGATTATGGTAAAATCCCTGA
TATTCAGGCACAGGAAGCAGCCTTGCATAAACAATGGGAAGAAATGCAGCAAAATGGCACTTTGCTTAAAAATGCTGTTA
CACAAGAGAGTATTGCGGGAGTTGTTAGTCGCTGGAGTGGGATTCCAATTAAAAAAATGCTCCAAAGCCAAAAGGAGCGC
ATTTTAGGCATAGAATCTGAACTTGCCAAAAGTGTAGTAGGACAAGATGATGCAATAAAAGCCATTGCTAGAGCAATCAA
ACGCAATAAAGCCGGATTAAATGATGCCTCTCGCCCTATTGGGAGCTTTTTATTTTTAGGACCAACAGGTGTAGGTAAAA
CACAATGTGCAAAAACTTTAGCAGAGTTTTTATTTGATAATGCCAAATCACTTGTGCGTATTGATATGAGTGAATATATG
GAAAAACACGCTGTAAGTAGGCTTGTAGGAGCACCTCCGGGCTATGTAGGCTATGAAGAAGGTGGCGTGCTTACTGAAGC
CATAAGACGTAAACCTTATAGTATTGTGCTTTTTGATGAGGTGGAAAAAGCCCATCCTGATGTGTTTAATATCCTTTTGC
AAGTGCTTGATGATGGGCGATTGACTGATAGTAAGGGTGTGAGCGTGGATTTTAGCAATACGATTATTATTTTAACAAGC
AATATTGCAAGTGATAAAATTATGGAGATTGGGGATAAGCAAGAGCGCCAAAAGGCTGTGAAAGAAGCACTTAAAATGTA
TTTTAAACCAGAATTTTTAAATCGCCTTGATGATGTAGTTGTGTTTAATCCGCTCGGACTTGCTGATATTACTCAAATTG
TGGATATTATGTTTAAGTCTTTGGCTAAAAGGGCGTTGGAGAAAGGTATTAATGTTACCCTTAGTCAAGAGGCTAGAGAG
CATATTGCCCAAGTAGGCTTTGATAGCGTATATGGCGCGCGTCCGCTAAAAAGGGCATTATATGAAGAGGTTGAGGATAG
ATTAGCAGATTTGATTTTGCGTGATGAGATTAAAGAGGGTGATAGAGTGAATTTTGCGCTTAAAAATGGCGAAATTTGCA
CACATATAGAAAAAGAATAG

Protein sequence :
MNLFEKLTNQMKETLDSAASLALHSSNQEISLAHIYWALLSNHQSVLNQALNKMNIDKTALELQARSEVDKLPKSSQVQK
ENLSISKELSSALNLAQGEAIKNGDSFIAVDMFLIANLKESTFVAIFKPLVDIAEFKKTLLSLRGESKIESQSGDDNLES
LSKFGIDLTQKALENTLDPVIGRDDEINAMMQILIRKSKNNPILLGEPGVGKTAVVEGLAQRIVAKAVPTSLQNKKLIAL
DMSALIAGAKYRGEFEERLKNVVDEVKKAGNIILFIDEIHTIVGAGASEGSMDAANILKPALARGELHTIGATTLKEYRK
YFEKDAALTRRFQPINVNEPSINEALQILRGIKPNLEAHHNVNITDAALVAAAKLSSRYITDRFLPDKAIDLIDEAAAEL
KMQIESEPLELSKIKKHIANLEVEKQALNMEKTNVNEARVLEIDKELENLREEKMSLEGKFEQEKSVFTRIATIKAELDS
LKRESELAKRSGDYNKAAEIDYGKIPDIQAQEAALHKQWEEMQQNGTLLKNAVTQESIAGVVSRWSGIPIKKMLQSQKER
ILGIESELAKSVVGQDDAIKAIARAIKRNKAGLNDASRPIGSFLFLGPTGVGKTQCAKTLAEFLFDNAKSLVRIDMSEYM
EKHAVSRLVGAPPGYVGYEEGGVLTEAIRRKPYSIVLFDEVEKAHPDVFNILLQVLDDGRLTDSKGVSVDFSNTIIILTS
NIASDKIMEIGDKQERQKAVKEALKMYFKPEFLNRLDDVVVFNPLGLADITQIVDIMFKSLAKRALEKGINVTLSQEARE
HIAQVGFDSVYGARPLKRALYEEVEDRLADLILRDEIKEGDRVNFALKNGEICTHIEKE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 1e-99 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpA NP_859640.1 ATP-dependent Clp protease ClpA VFG2084 Protein 3e-109 45
clpA NP_859640.1 ATP-dependent Clp protease ClpA VFG2076 Protein 1e-111 43