Gene Information

Name : merA (NE0839)
Accession : NP_840913.1
Strain : Nitrosomonas europaea ATCC 19718
Genome accession: NC_004757
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : 1.16.1.1
Position : 916637 - 918322 bp
Length : 1686 bp
Strand : -
Note : -

DNA sequence : 
ATGACCACGTTGAAGATCACCGGAATGACTTGCGACTCGTGCGCTACGCACGTCAAGCAAGCATTGGAGAAAGTGCCCGG
CGTGCAGTCTGCCGTTGTGTCCTACGCCAAGGGTGCGGCCCAGCTCGACCTTGACCCCGGCACCGCACCGGACGCGCTGA
CCGCCGCTGTGGCCGGACTCGGCTACAAGGCAACGCTCGCCGATGCCCCGCCGACGGACAACCGCACCGGGCTGCTCGAC
AAGGTGCGCGACTGGATGGGAGCCGCCGACAAGGGCAGCGACGGCGAGCACCCGTTGCAGGTCGCCGTGATCGGCAGCGG
CGGGGCCGCGATGGCGGCGGCGCTGAAGGCCGTCGAGCAAGGCGCGAAGGTCACGCTGATCGAACGCGGCACCATCGGCG
GCACTTGCGTCAATGTGGGCTGCGTACCGTCCAAGATCATGATCCGCGCTGCCCATATCGCCCATCTGCGCCGCGAAAGC
CCGTTCGACGGCGGCATCCCGGCGACTGCACCTGCAATTGATCGCAGCAAGCTGCTGGCCCAGCAGCAAGCACGCGTCGA
TGAGCTGCGCCACGCCAAGTACGAAGGCATCCTGGACGGCAACCCGGCCATCACCGTGTTGCATGGCGAAGCGCGTTTCA
AGGACGACCAGAGCCTTGTCGTCCGTTTGAACGCTGGCGGCGAGCGCGTCGTGGTGTTCGACCGCTGCCTAGTCGCCACG
GGTGCCAGCCCGGCCGTGCCGCCGATTCCGGGCTTGAAAGAGTCGCCCTACTGGACTTCGACCGAGGCCCTGGTCAGCGA
CATCATTCCCGAACGCCTGGCCGTGATCGGATCGTCGGTGGTGGCGCTGGAACTGGCGCAAGCCTTCGCCCGACTGGGCA
GCCAGGTCACGATCCTGGCGCGCAGCACGCTCTTCTTCCGCGAAGACCCGGCCATCGGCGAGGCAATCACGGCGGCGTTC
CGTGCTGAAGGGATCAAGGTGCTGGAACACACGCAAGCCAGCCAGGTCGCCCACGTGGACGGCGAATTCGTGCTGACCAC
GGCGCGCGGTGAAATACACGCCGACAAGCTGCTGGTCGCTACCGGCCGGACACCGAACACGCGCAGCCTGGCGCTGGAAG
CGGCGGGTGTCGCCGTCAATGCGCAGGGGGCTATCGTCATCGACAAAGGCATGCGCACCAGCGCGCCACACATCTATGCC
GCCGGCGATTGCACTGACCAACCGCAATTCGTCTATGTGGCAGCGGCCGCCGGCACCCGTGCCGCGATCAACATGACGGG
CGGCGACGCTACCCTGGACCTGACCGCGATGCCAGCAGTGGTGTTTACCGACCCGCAGGTCGCCACCGTGGGCTACAGCG
AAGCGGAAGCGCATCACGACGGGATCGAGACCGACAGTCGCACCTTAACCTTGGACAACGTGCCGCGTGCGCTGGCCAAC
TTCGACACACGCGGCTTTATCAAGCTGGTCATCGAGGAAGGTAGCGGGCGGCTCATTGGCGTGCAGGCGGTGGCCCCGGA
AGCGGGCGAACTGATCCAGACGGCAGCCCTGGCAATTCGCAACCGCATGACGGCGCAGGAACTGGCGGATCAGTTGTTCC
CCTACCTGACGATGGTCGAGGGGTTGAAGCTCGCGGCGCAGACCTTCAACAAGGATGTGAAGCAGCTTTCCTGCTGCGCC
GGGTGA

Protein sequence : 
MTTLKITGMTCDSCATHVKQALEKVPGVQSAVVSYAKGAAQLDLDPGTAPDALTAAVAGLGYKATLADAPPTDNRTGLLD
KVRDWMGAADKGSDGEHPLQVAVIGSGGAAMAAALKAVEQGAKVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAHLRRES
PFDGGIPATAPAIDRSKLLAQQQARVDELRHAKYEGILDGNPAITVLHGEARFKDDQSLVVRLNAGGERVVVFDRCLVAT
GASPAVPPIPGLKESPYWTSTEALVSDIIPERLAVIGSSVVALELAQAFARLGSQVTILARSTLFFREDPAIGEAITAAF
RAEGIKVLEHTQASQVAHVDGEFVLTTARGEIHADKLLVATGRTPNTRSLALEAAGVAVNAQGAIVIDKGMRTSAPHIYA
AGDCTDQPQFVYVAAAAGTRAAINMTGGDATLDLTAMPAVVFTDPQVATVGYSEAEAHHDGIETDSRTLTLDNVPRALAN
FDTRGFIKLVIEEGSGRLIGVQAVAPEAGELIQTAALAIRNRMTAQELADQLFPYLTMVEGLKLAAQTFNKDVKQLSCCA
G

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 0.0 91
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 0.0 91
merA ABQ57371.1 MerA Not tested SGI1 Protein 0.0 90
merA AGK07021.1 MerA Not tested SGI1 Protein 0.0 90
merA AGK07079.1 MerA Not tested SGI1 Protein 0.0 90
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 0.0 85
merA AFG30120.1 MerA Not tested PAGI-2 Protein 0.0 85
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 0.0 85
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 0.0 80
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 0.0 76
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 2e-88 42
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 1e-88 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
merA NP_840913.1 mercuric reductase BAC0652 Protein 0.0 91
merA NP_840913.1 mercuric reductase BAC0653 Protein 0.0 81
merA NP_840913.1 mercuric reductase BAC0650 Protein 3e-176 70
merA NP_840913.1 mercuric reductase BAC0651 Protein 8e-89 42
merA NP_840913.1 mercuric reductase BAC0224 Protein 1e-87 41