Gene Information

Name : thyA (NE0568)
Accession : NP_840652.1
Strain : Nitrosomonas europaea ATCC 19718
Genome accession: NC_004757
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 617059 - 617853 bp
Length : 795 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGTATCAGTACCTCGACCTGATGCGACATGTGTTGCAATACGGCCATAAAAAGAGTGATCGCACCGGCACCGGCACACT
CTCCGTTTTTGGCTATCAGATGCGCTTTGATCTGCAAACGGGTTTTCCGCTGGTGACAACCAAGAAATGTCATGTCAAAT
CGATCATTCATGAACTGCTATGGTTTCTGCGCGGCGAAACCAACATCGATTACCTGAAAAGAAACGGGGTTTCCATCTGG
GATGAATGGGCAGATGAAAACGGTGATCTGGGCCCGATCTACGGCCATCAGTGGCGATCCTGGGCAGCTTCCGACGGCAC
TGTCATTGACCAGATATCGCAAGTGATCCAGCAAATCAAAGAAACACCGGACTCACGCCGGATGATCGTCTCCGCATGGA
ATGTAGGTGATCTCGACAAAATGAAGCTCGCCCCCTGTCACGTACTGTTCCAGTTTTACGTGGCGGATGGCAGACTCTCC
TGCCAGCTTTACCAGCGCAGTGCCGATATCTTTCTGGGCGTTCCCTTCAACATTGCCTCTTATTCACTGCTGACACTGAT
GATCGCACAATGTTGCGACCTGCAGCCCGGCGAATTCGTCCATACCTTTGGTGATGCGCATCTGTATCTGAACCACCTTG
AACAGGCGCGGTTGCAACTGGAACGCGAACCCAGAGCACTCCCAGCCATGCAACTGAATTCAACAGTCAGAAATATCTTT
GATTTCGGATACGAGGATTTTACCTTGCACGATTATGATCCTTACCCGCCTATCAAGGCACCGGTGGCTGTATGA

Protein sequence :
MYQYLDLMRHVLQYGHKKSDRTGTGTLSVFGYQMRFDLQTGFPLVTTKKCHVKSIIHELLWFLRGETNIDYLKRNGVSIW
DEWADENGDLGPIYGHQWRSWAASDGTVIDQISQVIQQIKETPDSRRMIVSAWNVGDLDKMKLAPCHVLFQFYVADGRLS
CQLYQRSADIFLGVPFNIASYSLLTLMIAQCCDLQPGEFVHTFGDAHLYLNHLEQARLQLEREPRALPAMQLNSTVRNIF
DFGYEDFTLHDYDPYPPIKAPVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 2e-74 62