Gene Information

Name : leuS (NE1139)
Accession : NP_841196.1
Strain : Nitrosomonas europaea ATCC 19718
Genome accession: NC_004757
Putative virulence/resistance : Unknown
Product : leucyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0495
EC number : 6.1.1.4
Position : 1234324 - 1236933 bp
Length : 2610 bp
Strand : -
Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl

DNA sequence :
ATGCAAGAAAAATACCATCCCCAGGAAATAGAACGACAAGCCCGGCAAAGCTGGCAGGAAACAAACATTTTCAATGTGAC
TGAGATCCCAGACAGGCCAAAATACTACTGCCTTTCCATGTTTCCTTATCCTTCCGGCAAGCTGCATATGGGGCATGTGC
GCAACTATACGATCGGGGATGTATTGTCACGTTATCGCCGCATGCAGGGGTATAACGTCATGCAGCCGATGGGTTGGGAT
GCATTCGGATTGCCGGCCGAGAACGCTGCGATCCAGAAAGGAGTGCCACCCGCAAAATGGACTTATGACAATATCGCTTA
CATGCGCAGCCAGTTGCAAAGTCTGGGGTTTGCTATCGACTGGCAGCGTGAACTGGCCACTTGCGATCCACAGTATTACC
GCTGGAATCAGTGGCTGTTTCTGCGCATGCTGGAAAAGGGTATTGCCTATCAGAAAACGCAGGTGGTCAACTGGGATCCG
GTTGATCAGACTGTACTGGCCAACGAGCAAGTGATTGACGGATGCGGCTGGCGTACCGGTGCAGTGGTGGAAAAACGGGA
AATTCCGGGCTATTACCTGGCGATAACCCGCTACGCAGATGAATTGCTGGCCGACCTGGAAAAACTGCCAGGCTGGCCGG
AGCGCGTAAAAACCATGCAGGCCAACTGGATCGGCAAAAGCTTTGGTGTGGACATTACGTTCCCGCCGGATACTGCTTCC
GGCATGCCACAAGCGCTTAAGGTATTCACTACCCGGGCAGATACGCTGATGGGGGTGACCTATGTGGCGGTTGCGGCAGA
GCATCCGGTTGCTTTACATGCAGCACACAATCAGCCTGATCTGGTGGCTTTCATTGAATCCTGCCGGCAGGGTGCCACCA
TGGAAGCGGAGTTGGCTGTCCAGGAGAAAAAAGGGATGGCCACCGGGTTGTATGTCCTGCATCCGCTGACCGGTGAGCGT
CTGCCGGTATGGGTCGCCAACTATGTACTGATGAGCTACGGTGAAGGCGCTGTCATGGCGGTCCCGGCGCATGACGAACG
TGATTTTGATTTTGCCCGCCAGCATTCTCTGCCGATCAAACCGGTCATCAGGCCAGAAAATGGCGAGCTATCCGTACCAC
TCGTTCAGGCCTTTACCGAATATGGGGTAACGTTCAATTCCGACCGGTTTTCAGATCTGACATCACCGGAAGCGATCGAT
GCAATTGCAGTGGAACTGGGGCAGAAAGCGCTGGGTGAGAAACGGGTGCGGTATCGTTTACGCGACTGGGGAATTTCACG
TCAGCGTTACTGGGGCTGTCCGATTCCACTGATCCATTGTGATAGTTGCGGTGTAGTACCGGTAGCAGACGACCAGTTAC
CTGTTGTACTCCCAGAAGATCTGGTACCGGATGGTTCGGGCAATCCGCTGGCAAAAACACCTTCATTCTATGAGTGTACC
TGTCCACGTTGCGGGCGGCAGGCACGCCGCGAAACCGATACCATGGATACATTCGTCGATTCCTCATGGTATTTCATCCG
TTATGCCTGTCCGGATCAGTCTGCTGCCATGACCGACCAGCGGGCAAATTACTGGCTGCCGGTCGATCAGTACATCGGCG
GGATCGAGCATGCCATTCTGCACCTGTTGTATTCGCGTTTCTGGAGCAAGGTCATGCGCGATCTGGGGCTGGTGTCGTTC
GATGAACCCTTTGCCAATCTGTTGACACAAGGCATGGTGCTGAACGAGATATTTTTCCGTAAAACCAGCAGCGGGCGTAT
CCAGTATTTCAATCCGGCAGAAGTGGATGTGCAGCACGATGGAGAAGGAAAAAGAGTCGGCGCCGTTTTGCAGGCGGATA
ACCAACCGGTTGAATCCGGCGGTATCGGCACCATGTCAAAATCGAAAAACAACGGGATCGATCCACAAGAAATCATTGAG
CAATATGGGGCAGATACTGCGCGACTGTTCATGATGTTTGCCAGCCCGCCGACACAAACGCTGGAATGGTCGGATGCCGG
TGTCGAAGGTGCTTTCCGTTTTCTCAAGCGGTTGTGGCGACAAGTTTATTTGCACAGACAGCTGGATGGCGAAGCTGCTG
CGACTACTACTCTGGTACCGCATCAGGAATACCCGGCTGATCTGCGGGATTTGCGTTGCCAGTTGCATCAAACTATCGTC
AAAGTGACGGATGATCTTGAGCGGCGTCACACGTTCAATACTGCGATTGCAGCCATCATGGAGCTGATGAATGAGCTGTC
CGATGTACAGGGCACCCATCCGGCCGCACGCCAACTGATGCAGGAAGCACTGGAGAATATCGTGCTGCTGCTTTCACCCA
TCGTTCCGCATATCTGTCATGTATTGTGGCGTGAACTGAGACCGGGTACCGAACTGCTCGATCAACCCTGGCCGCAAGCA
GATGATCAGGCATTGATTCAGGATGAAGTTGAAATTGTCGTCCAGATCAATGGCAAGCTGCGCGGGCAGATACGCATTGC
CAGGGAAGCAGATCGGGCTGCTGTTGAACGAACAGCATTACAAGATGAGCATATACAAAAGAGTATAGCCTACCGGCCTG
TCAAGAGAGTCATCGTCGTGCCGGGAAAACTGATCAATATCGTTGTTTAG

Protein sequence :
MQEKYHPQEIERQARQSWQETNIFNVTEIPDRPKYYCLSMFPYPSGKLHMGHVRNYTIGDVLSRYRRMQGYNVMQPMGWD
AFGLPAENAAIQKGVPPAKWTYDNIAYMRSQLQSLGFAIDWQRELATCDPQYYRWNQWLFLRMLEKGIAYQKTQVVNWDP
VDQTVLANEQVIDGCGWRTGAVVEKREIPGYYLAITRYADELLADLEKLPGWPERVKTMQANWIGKSFGVDITFPPDTAS
GMPQALKVFTTRADTLMGVTYVAVAAEHPVALHAAHNQPDLVAFIESCRQGATMEAELAVQEKKGMATGLYVLHPLTGER
LPVWVANYVLMSYGEGAVMAVPAHDERDFDFARQHSLPIKPVIRPENGELSVPLVQAFTEYGVTFNSDRFSDLTSPEAID
AIAVELGQKALGEKRVRYRLRDWGISRQRYWGCPIPLIHCDSCGVVPVADDQLPVVLPEDLVPDGSGNPLAKTPSFYECT
CPRCGRQARRETDTMDTFVDSSWYFIRYACPDQSAAMTDQRANYWLPVDQYIGGIEHAILHLLYSRFWSKVMRDLGLVSF
DEPFANLLTQGMVLNEIFFRKTSSGRIQYFNPAEVDVQHDGEGKRVGAVLQADNQPVESGGIGTMSKSKNNGIDPQEIIE
QYGADTARLFMMFASPPTQTLEWSDAGVEGAFRFLKRLWRQVYLHRQLDGEAAATTTLVPHQEYPADLRDLRCQLHQTIV
KVTDDLERRHTFNTAIAAIMELMNELSDVQGTHPAARQLMQEALENIVLLLSPIVPHICHVLWRELRPGTELLDQPWPQA
DDQALIQDEVEIVVQINGKLRGQIRIAREADRAAVERTALQDEHIQKSIAYRPVKRVIVVPGKLINIVV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
leuS YP_281511.2 leucyl-tRNA synthetase Not tested Not named Protein 1e-154 41