Gene Information

Name : yhcI (S3475)
Accession : NP_838724.2
Strain : Shigella flexneri 2457T
Genome accession: NC_004741
Putative virulence/resistance : Virulence
Product : N-acetylmannosamine kinase
Function : -
COG functional category : K : Transcription
COG ID : COG1940
EC number : 2.7.1.60
Position : 3346653 - 3347528 bp
Length : 876 bp
Strand : -
Note : catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein

DNA sequence : 
ATGACCATACTGGCGATTGATATCGGCGGTACTAAACTTGCCGCCGCGCTGATTGGCGCTGACGGGCAGATCCGCGATCG
TCGTGAACTTCCTACGCCAGCCAGCCAGACACCAGAAGCCTTGCGTGATGCCTTATCCGCATTAGTCTCTCCGTTGCAAG
CTCATGCGCAGCGGGTTGCCATCGCTTCAACCGGAATTATTCGCGACGGCAGTTTGCTGGCGCTGAATCCGCATAATCTC
GGTGGATTGCTACACTTTCCGTTAGTCAAAACGCTGGAACAACTTACCAATTTGCCGACCATTGCCATTAACGACGCGCA
GGCCGCAGCATGGGCAGAGTATCAGGCGCTGGAAGGCGATATAACCGATATGGTCTTTATCACCGTTTCCACTGGCGTCG
GCGGCGGTGTAGTGAGCGGCGGCAAACTGCTTACCGGCCCTGGCGGTCTGGCGGGGCACATCGGGCATACGCTTGCCGAT
CCACACGGCCCAGTCTGCGGCTGTGGACGCACAGGTTGCGTGGAAGCAATTGCTTCTGGTCGCGGCATTGCGGCGGCAGC
GCAGGGCGAGCTGGCTGGCGCGGATGCGAGAACTATTTTCACACGCGCCGGGCAGGGCGATGAGCAGGCGCAGCAACTGA
TTCATCGCTCCGCACGTACGCTTGCAAGGCTGATCGCTGATATTAAAGCCACAACTGATTGCCAGTGCGTGGTGGTTGGT
GGCAGCGTTGGTCTGGCAGAAGGGTATCTGGCGTTGGTGGAAATGTATCTGGCGCAGGAGCCAGCGGCATTTCATGTTGA
TTTACTGGCGGCGCATTACCGCCATGATGCAGGTTTACTTGGGGCTGCGCTGTTGGCCCAGGGAGAAAAATTATGA

Protein sequence : 
MTILAIDIGGTKLAAALIGADGQIRDRRELPTPASQTPEALRDALSALVSPLQAHAQRVAIASTGIIRDGSLLALNPHNL
GGLLHFPLVKTLEQLTNLPTIAINDAQAAAWAEYQALEGDITDMVFITVSTGVGGGVVSGGKLLTGPGGLAGHIGHTLAD
PHGPVCGCGRTGCVEAIASGRGIAAAAQGELAGADARTIFTRAGQGDEQAQQLIHRSARTLARLIADIKATTDCQCVVVG
GSVGLAEGYLALVEMYLAQEPAAFHVDLLAAHYRHDAGLLGAALLAQGEKL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
nanK YP_002414055.1 N-acetylmannosamine kinase Not tested Not named Protein 4e-38 53
VPI2_0030 ACA01847.1 ROK family protein Not tested VPI-2 Protein 1e-26 41
VC1782 NP_231417.1 N-acetylmannosamine kinase Not tested VPI-2 Protein 1e-26 41
VC0395_A1379 YP_001217322.1 N-acetylmannosamine kinase Not tested VPI-2 Protein 1e-26 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
yhcI NP_838724.2 N-acetylmannosamine kinase VFG1115 Protein 6e-27 41