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Name : pic (S3178) Accession : NP_838464.1 Strain : Shigella flexneri 2457T Genome accession: NC_004741 Putative virulence/resistance : Virulence Product : serine protease precurser Function : - COG functional category : M : Cell wall/membrane/envelope biogenesis COG ID : COG3468 EC number : - Position : 3059914 - 3063126 bp Length : 3213 bp Strand : - Note : residues 1 to 1070 of 1070 are 96.16 pct identical to residues 304 to 1373 of 1373 from GenPept : >gb|AAK00464.1| (AF200692) Pic [Shigella flexneri 2a] DNA sequence : ATGCAGGACGATTTCGATGCCCCCGTAGACTTTGTTTCCGGACTGGGCCCCCTGAACTGGACATACGACAAAACATCAGG CACAGGTACCCTGAGCCAGGGCAGTAAAAACTGGACCATGCACGGGCAGAAAGACAATGACCTCAATGCCGGTAAAAATC TGGTATTCAGCGGGCAGAATGGTGCAATTATCCTGAAAGACAGTGTGACTCAGGGTGCCGGTTATCTCGAATTTAAAGAC AGTTACACCGTATCTGCTGAATCCGGAAAAACATGGACGGGTGCCGGCATTATTACTGACAAGGGGACGAATGTAACCTG GAAGGTCAACGGCGTTGCCGGTGACAACTTGCATAAGCTGGGGGAAGGAACCCTGACCATAAACGGAACAGGTGTAAACC CGGGAGGACTGAAAACGGGAGACGGTATCGTTGTACTTAACCAGCAGGCAGACACTGCAGGTAATATCCAGGCCTTCAGT TCAGTGAACCTCGCCAGCGGACGTCCGACCGTGGTGCTCGGGGATGCCCGTCAGGTCAATCCGGATAACATTTCATGGGG ATACCGGGGAGGTAAGCTTGACCTTAATGGTAATGCCGTTACCTTCACCCGACTGCAGGCTGCTGATTACGGGGCGGTGA TTACAAATAATGCACAGCAAAAATCCCAGCTTTTACTGGATCTTAAGGCTCAGGATACAAATGTCAGTGAACCGACGATT GGAAATATATCCCCCTTTGGTGGTACCGGCACTCCAGGAAACCTGTACAGCATGATACTCAACAGCCAGACCCGCTTCTA TATTCTGAAATCTGCCAGCTATGGTAACACTCTGTGGGGGAACAGCCTGAATGATCCGGCTCAGTGGGAGTTTGTTGGCA TGAACAAAAACAAAGCAGTTCAGACAGTAAAAGATAGGATCCTGGCCGGGCGGGCAAAACAACCCGTTATCTTTCATGGT CAGCTGACCGGGAATATGGATGTCGCCATTCCACAGGTGCCGGGGGGAAGAAAGGTAATCTTTGATGGTAGCGTGAACCT GCCGGAAGGTACCCTGAGTCAGGACAGTGGCACCCTGATATTCCAGGGACATCCGGTTATCCATGCCTCCATCAGTGGCA GTGCACCGGTCAGCCTGAACCAGAAAGACTGGGAAAACCGTCAGTTTACAATGAAAACACTGTCGCTGAAAGACGCTGAC TTCCATCTTTCACGTAACGCCTCGCTGAACAGTGACATTAAGTCGGATAACAGCCATATCACACTGGGAAGTGACAGGGC ATTTGTGGATAAAAATGACGGAACAGGAAATTATGTCATTCCGGAGGAAGGTACCTCTGTCCCGGACACCGTGAATGACA GGAGCCAGTATGAAGGGAATATTACGCTGAACCATAACTCAGCCCTGGATATCGGCAGCAGGTTCACCGGGGGGATTGAC GCTTATGACAGTGCCGTCAGCATCACCTCTCCGGACGTCCTGTTGACAGCCCCGGGTGCTTTTGCCGGCAGTTCACTGAC AGTGCATGATGGCGGTCATCTTACAGCACTGAACGGTCTTTTCAGCGACGGGCATATTCAGGCCGGTAAGAACGGCAAAA TCACCCTGAGCGGTACACCGGTTAAAGATACGGCTAATCAGTATGCCCCTGCTGTATATCTGACGGACGGATATGACCTG ACCGGCGATAACGCAGCACTGGAAATTACCCGTGGAGCACATGCTTCCGGTGATATTCATGCCTCTGCGGCATCAACAGT TACCATCGGGTCTGACACGCCGGCAGAACTGGCTTCTGCGGAAACGGCTGCATCGGCGTTTGCCGGCAGTCTTCTTGAGG GCTATAACGCAGCATTCAATGGTGCCATAACCGGTGGCAGGGCTGATGTCAGTATGCATAATGCACTGTGGACTCTGGGT GGGGACTCTGCCATCCACAGTCTTACCGTCAGAAACAGCCGTATTAGTTCTGAAGGAGACCGTACATTCCGTACCCTGAC GGTGAATAAACTGGATGCAACAGGCAGTGATTTTGTTTTGCGTACGGACCTGAAAAATGCCGATAAAATTAATGTGACTG AAAAAGCCACTGGTTCAGATAACAGCCTGAACGTCAGCTTTATGAATAATCCTGCTCAGGGACAGGCCCTGAATATTCCT CTGGTCACGGCACCGGCGGGAACTTCAGCAGAGATGTTTAAGGCCGGCACCCGGGTGACAGGTTTCAGTCGGGTGACCCC AACCCTGCATGTTGATACCAGTGGTGGCAATACGAAGTGGATACTGGATGGTTTTAAAGCGGAGGCTGATAAAGCCGCTG CCGCGAAGGCTGACAGTTTCATGAATGCCGGGTATAAAAACTTCATGACGGAAGTTAACAATCTGAACAAACGTATGGGT GACCTGCGTGACACAAACGGTGATGCCGGTGCCTGGGCGCGCATCATGAGTGGTGCCGGTTCTGCAGACGGTGGTTACAG TGATAATTACACCCATGTTCAGGTCGGCTTTGACAAAAAACATGAACTGGACGGTGTGGACCTGTTTACCGGTGTCACGA TGACCTATACCGACAGCAGTGCAGACAGCCATGCATTCAGCGGAAAGACGAAATCGGTGGGGGGCGGTCTGTATGCTTCA GCATTGTTTGAGTCCGGTGCCTATATCGATTTGATTGGTAAATATATTCACCATGACAATGATTACACAGGTAACTTTGC TAGCCTGGGAACGAAACACTACAACACCCATTCCTGGTATGCCGGTGCTGAAACGGGTTACCGCTATCACCTGACAGAGG ACACGTTCATTGAGCCGCAGGCTGAACTGGTTTACGGCGCCGTGTCCGGGAAAACATTCCGCTGGAAAGACGGTGATATG GACCTGAGCATGAAGAACAGGGACTTCAGTCCGCTGGTTGGAAGAACAGGGGTTGAACTGGGCAAGACCTTCAGTGGTAA GGACTGGAGTGTGACGGCCCGTGCCGGAACCAGCTGGCAGTTTGACCTGCTGAATAATGGAGAGACCGTACTGCGTGATG CGTCCGGGGAGAAACGGATAAAAGGAGAGAAGGACAGCCGGATGCTGTTTAATGTTGGTATGAATGCGCAGATAAAGGAC AATATGCGCTTTGGTCTGGAGTTTGAGAAGTCAGCCTTTGGTAAATATAACGTGGATAATGCGGTAAACGCGAATTTCCG GTATATGTTCTGA Protein sequence : MQDDFDAPVDFVSGLGPLNWTYDKTSGTGTLSQGSKNWTMHGQKDNDLNAGKNLVFSGQNGAIILKDSVTQGAGYLEFKD SYTVSAESGKTWTGAGIITDKGTNVTWKVNGVAGDNLHKLGEGTLTINGTGVNPGGLKTGDGIVVLNQQADTAGNIQAFS SVNLASGRPTVVLGDARQVNPDNISWGYRGGKLDLNGNAVTFTRLQAADYGAVITNNAQQKSQLLLDLKAQDTNVSEPTI GNISPFGGTGTPGNLYSMILNSQTRFYILKSASYGNTLWGNSLNDPAQWEFVGMNKNKAVQTVKDRILAGRAKQPVIFHG QLTGNMDVAIPQVPGGRKVIFDGSVNLPEGTLSQDSGTLIFQGHPVIHASISGSAPVSLNQKDWENRQFTMKTLSLKDAD FHLSRNASLNSDIKSDNSHITLGSDRAFVDKNDGTGNYVIPEEGTSVPDTVNDRSQYEGNITLNHNSALDIGSRFTGGID AYDSAVSITSPDVLLTAPGAFAGSSLTVHDGGHLTALNGLFSDGHIQAGKNGKITLSGTPVKDTANQYAPAVYLTDGYDL TGDNAALEITRGAHASGDIHASAASTVTIGSDTPAELASAETAASAFAGSLLEGYNAAFNGAITGGRADVSMHNALWTLG GDSAIHSLTVRNSRISSEGDRTFRTLTVNKLDATGSDFVLRTDLKNADKINVTEKATGSDNSLNVSFMNNPAQGQALNIP LVTAPAGTSAEMFKAGTRVTGFSRVTPTLHVDTSGGNTKWILDGFKAEADKAAAAKADSFMNAGYKNFMTEVNNLNKRMG DLRDTNGDAGAWARIMSGAGSADGGYSDNYTHVQVGFDKKHELDGVDLFTGVTMTYTDSSADSHAFSGKTKSVGGGLYAS ALFESGAYIDLIGKYIHHDNDYTGNFASLGTKHYNTHSWYAGAETGYRYHLTEDTFIEPQAELVYGAVSGKTFRWKDGDM DLSMKNRDFSPLVGRTGVELGKTFSGKDWSVTARAGTSWQFDLLNNGETVLRDASGEKRIKGEKDSRMLFNVGMNAQIKD NMRFGLEFEKSAFGKYNVDNAVNANFRYMF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| pic | NP_838464.1 | serine protease precurser | Virulence | SHI-1 | Protein | 0.0 | 100 |
| pic | NP_708747.3 | serine protease | Not tested | SHI-1 | Protein | 0.0 | 100 |
| she | AAB58244.1 | mucinase | Virulence | SHI-1 | Protein | 0.0 | 99 |
| pic | AAK00464.1 | Pic | Virulence | SHI-1 | Protein | 0.0 | 99 |
| unnamed | CAC39286.1 | hypothetical protein | Not tested | LPA | Protein | 0.0 | 54 |
| vat | YP_851472.1 | vacuolating autotransporter | Not tested | PAI III APEC-O1 | Protein | 0.0 | 49 |
| unnamed | CAD66214.1 | putative hemoglobin protease | Not tested | PAI III 536 | Protein | 0.0 | 49 |
| vat | AAO21903.1 | vacuolating autotransporter toxin | Virulence | Not named | Protein | 0.0 | 48 |
| espC | AAG37043.1 | enterotoxin EspC | Virulence | espC PAI | Protein | 0.0 | 46 |
| sigA | NP_708742.1 | serine protease | Virulence | SHI-1 | Protein | 2e-170 | 43 |
| sigA | AAF67320.1 | exported serine protease SigA | Virulence | SHI-1 | Protein | 1e-170 | 43 |
| sigA | NP_838462.1 | serine protease | Virulence | SHI-1 | Protein | 2e-170 | 43 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| pic | NP_838464.1 | serine protease precurser | VFG0635 | Protein | 0.0 | 100 |
| pic | NP_838464.1 | serine protease precurser | VFG0861 | Protein | 0.0 | 99 |
| pic | NP_838464.1 | serine protease precurser | VFG0903 | Protein | 0.0 | 97 |
| pic | NP_838464.1 | serine protease precurser | VFG1689 | Protein | 0.0 | 49 |
| pic | NP_838464.1 | serine protease precurser | VFG0904 | Protein | 0.0 | 49 |
| pic | NP_838464.1 | serine protease precurser | VFG0772 | Protein | 0.0 | 46 |
| pic | NP_838464.1 | serine protease precurser | VFG0630 | Protein | 7e-171 | 43 |
| pic | NP_838464.1 | serine protease precurser | VFG0844 | Protein | 3e-175 | 43 |
| pic | NP_838464.1 | serine protease precurser | VFG0862 | Protein | 3e-171 | 42 |
