Gene Information

Name : nrdE (S2889)
Accession : NP_838213.1
Strain : Shigella flexneri 2457T
Genome accession: NC_004741
Putative virulence/resistance : Unknown
Product : ribonucleotide-diphosphate reductase subunit alpha
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0209
EC number : 1.17.4.1
Position : 2769917 - 2772022 bp
Length : 2106 bp
Strand : +
Note : Catalyzes the rate-limiting step in dNTP synthesis

DNA sequence :
ATGGATTACCACGCGCTGAATGCGATGCTTAATCTTTACGATAGCGCAGGTCGCATTCAGTTCGATAAAGACCGCCAGGC
CGTTGACGCCTTTATTGCGACGCATGTGCGTCCGAACAGTGTGACCTTCAGTAGCCAGCAGCAGCGCCTGAACTGGCTGG
TCAACGAAGGTTACTATGATGAAAGCGTTCTTAATCGCTACTCTCGCGACTTTGTCATTACGCTGTTTGCCCACGCACAC
ACCAGCGGTTTTCGTTTCCAGACATTCCTCGGGGCATGGAAGTTTTACACCAGCTATACGTTGAAGACATTCGACGGTAA
ACGTTATCTGGAAGATTTTGCCGATCGAGTCACGATGGTGGCGCTGACGCTGGCACAAGGCGATGAGACGCTGGCGTTGC
AACTGACCGATGAAATGCTGTCAGGACGCTTTCAGCCAGCCACGCCAACATTCCTCAACTGCGGTAAGCAGCAGCGCGGC
GAACTGGTTTCCTGTTTTTTGCTGCGTATTGAAGACAATATGGAGTCGATTGGTCGGGCGGTAAATTCCGCACTGCAGCT
GTCGAAACGCGGCGGCGGCGTAGCATTTTTGCTGTCGAATCTGCGGGAAGCGGGCGCGCCAATTAAACGTATTGAAAATC
AATCTTCTGGCGTAATTCCGGTGATGAAAATGTTGGAAGACGCATTTTCCTATGCCAACCAACTCGGCGCGCGTCAGGGG
GCAGGTGCAGTCTATTTACATGCTCATCATCCCGATATTCTGCGTTTTCTCGACACGAAACGGGAAAATGCCGACGAAAA
AATCCGCATTAAAACACTGTCGCTGGGCGTGGTGATCCCGGATATCACTTTCCATCTGGCAAAAGAGAATGCGCAGATGG
CGCTGTTTTCGCCCTATGACGTTGAGCGAGTTTATGGCAAGCCGTTTGCCGATATCGCCATTAGCGAACACTATGACGAA
CTGGTTGCCGATGAACGCATCCGCAAAAAATACCTCAACGCCCGTGATTTCTTCCAGCGACTGGCAGAAATCCAGTTTGA
GTCCGGCTATCCCTACATCATGTATGAAGACACAGTAAACCGTGCTAACCCTATCGCCGGGCGCATAAATATGAGTAATC
TCTGCTCAGAAATTTTGCAGGTTAACAGCGCCTCAGAGTATGACGAGAATCTCGACTATGCCCGCACAGGCCATGATATT
TCCTGCAATTTAGGTTCGTTGAATATTGCGCACACCATGGATTCCCCCGATTTTTCCCGCACGGTAGAGACTGCCGTGCG
CGGTTTAACGGCGGTGTCAGATATGAGTCATATCCGCAGCGTGCCGTCCATCGAAGCCGGAAATGCCGCCTCGCACGCCA
TCGGACTGGGGCAGATGAATTTACATGGTTATCTGGCGAGGGAAGGCATCGCTTATGGTTCGCCGGAAGCCCTGGATTTC
ACCAATCTCTATTTCTATACCATCACCTGGCACGCACTGCGTACCTCGATGTTGCTGGCGCGCGAACGCGGTGAAACCTT
CGCCGGGTTCAAACAGTCACGCTATGCCAGTGGTGAATATTTCAGCCAATATCTGCAAGGTAACTGGCAGCCGAAAACGG
CGAAAGTTGGCGAACTGTTTGCCCGCAGCTGTATTACGTTACCTACCCGTGAGATGTGGGCGCAACTGCGCGACGACGTG
ATGCGCTACGGCATATACAACCAGAATCTCCAGGCGGTGCCGCCAACCGGGTCTATCTCTTATATCAACCATGCTACGTC
GAGTATTCATCCGATTGTGGCGAAAGTAGAGATACGCAAAGAGGGCAAAACAGGACGCGTTTACTACCCTGCCCCGTTTA
TGACTAACGAAAATCTGGCGCTGTATCAGGACGCTTACGAAATTGGCGCAGAAAAGATCATCGACACCTACGCGGAAGCG
ACTCGCCATGTCGATCAGGGGCTGTCGCTGACGCTGTTTTTCCCCGATACCGCCACCACTCGCGATATCAACAAAGCGCA
GATTTACGCCTGGCGCAAAGGTATCAAAACGCTCTATTACATCCGCCTGCGTCAGATGGCGCTGGAAGGCACTGAAATTG
AAGGCTGCGTCTCCTGTGCACTTTAA

Protein sequence :
MDYHALNAMLNLYDSAGRIQFDKDRQAVDAFIATHVRPNSVTFSSQQQRLNWLVNEGYYDESVLNRYSRDFVITLFAHAH
TSGFRFQTFLGAWKFYTSYTLKTFDGKRYLEDFADRVTMVALTLAQGDETLALQLTDEMLSGRFQPATPTFLNCGKQQRG
ELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQG
AGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFHLAKENAQMALFSPYDVERVYGKPFADIAISEHYDE
LVADERIRKKYLNARDFFQRLAEIQFESGYPYIMYEDTVNRANPIAGRINMSNLCSEILQVNSASEYDENLDYARTGHDI
SCNLGSLNIAHTMDSPDFSRTVETAVRGLTAVSDMSHIRSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDF
TNLYFYTITWHALRTSMLLARERGETFAGFKQSRYASGEYFSQYLQGNWQPKTAKVGELFARSCITLPTREMWAQLRDDV
MRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKVEIRKEGKTGRVYYPAPFMTNENLALYQDAYEIGAEKIIDTYAEA
TRHVDQGLSLTLFFPDTATTRDINKAQIYAWRKGIKTLYYIRLRQMALEGTEIEGCVSCAL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cur_1481 YP_001800875.1 ribonucleotide-diphosphate reductase subunit alpha Not tested Not named Protein 0.0 73