Gene Information

Name : kdsB (S0978)
Accession : NP_836623.1
Strain : Shigella flexneri 2457T
Genome accession: NC_004741
Putative virulence/resistance : Virulence
Product : 3-deoxy-manno-octulosonate cytidylyltransferase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG1212
EC number : 2.7.7.38
Position : 958606 - 959352 bp
Length : 747 bp
Strand : +
Note : CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS

DNA sequence :
ATGAGTTTTGTGGTCATTATTCCCGCGCGCTACGCGTCCACGCGTCTGCCCGGTAAACCATTGGTTGATATTAACGGCAA
ACCCATGATTGTTCATGTTCTTGAACGCGCGCGTGAATCAGGTGCCGAGCGCATCATCGTGGCAACCGATCATGATGATG
TTGCCCGCGCCGTTGAAGCCGCTGGCGGTGAAGTATGTATGACGCGCGCCGATCATCAGTCAGGAACAGAACGTCTGGCG
GAAGTTGTCGAAAAATGCGCATTCAGCGACGACACGGTGATCGTTAATGTGCAGGGTGATGAACCGATGATCCCTGCGAC
AATCATTCGTCAGGTTGCTGATAACCTCGCTCAGCGTCAGGTGGGTATGGCGACTCTGGCGGTGCCAATCCACAATGCGG
AAGAAGCGTTTAACCCGAATGCGGTGAAAGTGGTTCTCGACGCTGAAGGGTATGCACTGTACTTCTCACGTGCCACCATT
CCTTGGGATCGTGATCGTTTTGCAGAAGGCCTTGAAACCGTTGGCGATAACTTCCTGCGTCATCTTGGTATTTATGGCTA
CCGTGCAGGCTTTATCCGTCGTTACGTCAACTGGCAGGCAAGTCCGTTAGAACACATCGAAATGTTAGAGCAGCTTCGTG
TTCTGTGGTACGGCGAAAAAATCCATGTTGCTGTTGCTCAGGAAGTTCCTGGCACAGGTGTGGATACCCCTGAAGATCTT
GAGCGCGTTCGCGCTGAAATGCGCTAA

Protein sequence :
MSFVVIIPARYASTRLPGKPLVDINGKPMIVHVLERARESGAERIIVATDHDDVARAVEAAGGEVCMTRADHQSGTERLA
EVVEKCAFSDDTVIVNVQGDEPMIPATIIRQVADNLAQRQVGMATLAVPIHNAEEAFNPNAVKVVLDAEGYALYFSRATI
PWDRDRFAEGLETVGDNFLRHLGIYGYRAGFIRRYVNWQASPLEHIEMLEQLRVLWYGEKIHVAVAQEVPGTGVDTPEDL
ERVRAEMR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
kpsU AAZ04469.1 CMP-KDO synthetase Virulence PAI I APEC-O1 Protein 8e-35 45
kpsU YP_854332.1 3-deoxy-manno-octulosonate cytidylyltransferase Not tested PAI I APEC-O1 Protein 1e-34 45
kpsU CAE85213.1 KpsU protein Virulence PAI V 536 Protein 2e-34 45