Gene Information

Name : serS-1 (EF0100)
Accession : NP_813903.1
Strain : Enterococcus faecalis V583
Genome accession: NC_004668
Putative virulence/resistance : Unknown
Product : seryl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0172
EC number : 6.1.1.11
Position : 103833 - 105104 bp
Length : 1272 bp
Strand : +
Note : catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA

DNA sequence :
ATGCTGGATATGAAAAAAATTCGCCAAAATGTAGAAGTGGTACAGAAAAAGTTAAAAACACGTGGTGTGGACGAGGAAGT
TTTATTACGCTTTTTGGCTTTAGATGAAGGACGGAGAGCGTTACTTGTTAAAGTTGAAGAACTGAAAAAACACCGTAATC
AGGTGTCAGGAGAAATTGCACAATTAAAGCGTGCACAAAAAGATGCTTCACAACAATTGCTAAATATGCAAGAAGTTAGC
GAGCAAATTAAAGTTTTAGATCAAGAAGTTGTTCATTTGCAAGAACAATGCACAGCCATTGCAGAACGTTTGCCTAACTT
ACCTCATGAGAGCGTACCTGTTGGCGCAGACGAAGCCGCCAACGTAGAAGTTCGGCGGTGGAGTACGCCGAAAACTTTTT
CATTTGAACCAAAACCACATTGGGAAATCGGTGAAGCCTTAGGAATTTTAGATTTTGAAAGAGGCGCGAAAGTATCTGGT
AGCCGTTTTCTTTATTACAAAGGCTTAGGGGCTCGTTTAGAACGAGCGGTCTATAATTTTATGTTAGATCAACATGTTAA
TGAACATGGTTATACCGAAGTGATTCCTCCTTATTTGGTCAATAGCAAAGCAATGTTTGGCACCGGTCAGTTTCCTAAGT
TCAAAGAAGATGTTTTCCAAGTTGCAGAAAGTGATTTGACGCTGATCCCCACAGCGGAAGTCCCGTTAACTAACTACTAT
AATAATGAAATTTTAGATGCGCAAGAGTTACCGATTTATTTTACTGCTTTAAGTCCTTCTTTTCGCTCGGAAGCGGGTAG
TGCAGGTCGTGATACCCGAGGATTAATTCGTTTACACCAGTTTCATAAAGTAGAAATGGTTAAATTTAGTGATGCAGAAC
ACTCCTATGAAGAATTAGAAAAAATGACCAACAATGCTGGAGACATTTTAGAAAAATTGGGCCTCCCTTATCGAGTGATT
ACTCTTTCGACAGGTGACATGGGCTTCTCGGCAGCGAAAACCTATGATTTAGAAGTTTGGATTCCGGCACAGAAAACGTA
TCGAGAAATTAGTTCTTGTTCAAACTGTGAAGACTTCCAAGCACGTCGGGCGTTGATTCGTTATCGTGATAAAACGGGTC
ATGTTCAATATGCCCATACTCTTAATGGGTCAGGACTTGCTGTTGGTCGAACAGTGGCTGCCATTTTGGAAAATTATCAA
AATGAAGATGGCACCGTAACGATTCCAGAAGTTCTACGTCCTTATATGGGCGGTTTAACGAAAATAGATTAA

Protein sequence :
MLDMKKIRQNVEVVQKKLKTRGVDEEVLLRFLALDEGRRALLVKVEELKKHRNQVSGEIAQLKRAQKDASQQLLNMQEVS
EQIKVLDQEVVHLQEQCTAIAERLPNLPHESVPVGADEAANVEVRRWSTPKTFSFEPKPHWEIGEALGILDFERGAKVSG
SRFLYYKGLGARLERAVYNFMLDQHVNEHGYTEVIPPYLVNSKAMFGTGQFPKFKEDVFQVAESDLTLIPTAEVPLTNYY
NNEILDAQELPIYFTALSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFSDAEHSYEELEKMTNNAGDILEKLGLPYRVI
TLSTGDMGFSAAKTYDLEVWIPAQKTYREISSCSNCEDFQARRALIRYRDKTGHVQYAHTLNGSGLAVGRTVAAILENYQ
NEDGTVTIPEVLRPYMGGLTKID

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
serS YP_003446791.1 seryl-tRNA synthetase Not tested The aminoglycoside resistance gene cluster Protein 9e-149 70