Gene Information

Name : clpC (EF3282)
Accession : NP_816879.1
Strain : Enterococcus faecalis V583
Genome accession: NC_004668
Putative virulence/resistance : Virulence
Product : ATP-dependent Clp protease, ATP-binding protein ClpC
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 3157526 - 3160021 bp
Length : 2496 bp
Strand : -
Note : similar to GB:X57204, and PID:457413; identified by sequence similarity

DNA sequence :
ATGGATGAACTATTTACAGAAAGTGCGAAAGCCGTACTGGCGATTGCCCAAGAAGAAGCGAAGTATTTTCGTCACCAATC
CGTCGGTTCTGAACATTTATTATTAGCACTCGTTTTAGAACCAAATGGGATTGCCGGAAAAACATTACGACAATTGAATA
CTGACACAGAAGACATCCGTGAAGAAATTGAGCATTTAAGTGGCTATGGCACCATGCAAAGTCCAATGGGAAATAACAAC
TTATACTTACCTTATTCACCAAGAGCCAAACAAATCTTTGCCTATGCTGGAGATGAAGCGAAGCGCTTAGGGGCTCAAAA
GATTGGTACCGAGCATTTATTATTAGGCTTGTTAAGAGACGAAGAAATTTTAGCGTCTAGAATTTTAGTGAATTTAGGAT
TAAGCTTATCCAAAATGCGTCAATTATTATTGAAAAAAATGGGCGTTTCCGAACCCAATGGCGCACAACGTCGTCGGAAT
GGTCAAAATAAAAATGCGCCACAAGGGACGCCAACATTGGATTCTTTAGCAAGAGATTTAACCAAGTTAGCACGAGAACA
AAGCTTGGATCCAGTAGTTGGTCGCGGTACCGAAGTCCGTCGTTTGATTCAAATTTTGAGTCGCCGTACCAAAAACAATC
CTGTCTTAGTCGGTGAACCAGGTGTTGGGAAAACAGCGATAGCAGAAGGGTTAGCCCAGAAAATTGTCAACCGAGAAGTC
CCTGAAGATATGCAAGGCAAACGTTTAATGATGCTAGACATGGGTGCCTTGGTTGCTGGAACCAAATATCGAGGTGAGTT
CGAAGATCGCTTGAAAAAAGTTGTCGATGAAATCTATCAAGATGGACAAGTCATTTTATTTATTGACGAATTGCATACCT
TGATCGGTGCTGGCGGTGCAGAAGGGGCGATTGATGCTTCAAATATTTTAAAACCTGCTTTAGCACGTGGCGAGTTGCAA
ACAATTGGTGCGACAACTCTGGATGAATACCAAAAATATATTGAAAAAGATGCCGCTTTGGAACGTCGTTTTGCCCGTAT
TCAAGTAGCAGAACCAACCCCAGAAGAAGCAGAAGAAATTCTAAAAGGCTTGCGTTCCCGCTATGAAAAACATCATGGCG
TAGAAATTACAGATGAAGCTCTACATGCAGCGGTTCAATTATCGATTCGCTATTTAAATGACCGCCAATTACCAGATAAA
GCAATTGATTTAATGGACGAATCTGCAGCAAAAGTTCGTTTAGATAAGGCAGATCAACCTTCAGAAATTAATGAATTGCG
TACCGAAATTTCTCAATTAATTACGGAAAAAGAAGAGGCCATTCAAAACCAATCATTTGAAAGTGCTGCTCGGATTCGTC
AAAAAGAAAAACAAGTGATGGAAAAACTAGAAGAATTGATTGCAGTGAAAGAAAAAAGTCTGTCTGGTTACAGTACACAA
GTAACAGAAGAAGACGTGGCTGGGGTTGTTTCACAATGGACAGGCGTTCCTTTGCAGCAGCTAGAGAAGAAAGAAAGCGA
ACGATTGATGGAATTAGAAACCATTTTACATCAACGGGTCGTTGGCCAAAATGAAGCAGTTGAAGCTGTTTCACGCGCTA
TCCGTCGTGCGCGTAGTGGCTTGAAAGACCCAGCAAGACCGATTGGTTCCTTCATGTTCTTAGGACCAACAGGGGTTGGG
AAAACAGAACTTGCCAAAGCCTTAGCCGAAGCGATGTTTGGCAGCGAAGAAGCTTTGATTCGCGTGGACATGTCTGAGTT
TATGGAAAAATACAGTACTAGCCGTTTAATCGGTTCTCCTCCAGGTTATGTCGGCTACGAAGAAGGCGGTCAACTAACTG
AAAAAATTCGTCAACGTCCTTATTCCGTTATTTTGCTAGATGAAGTAGAAAAAGCCCATCCAGATGTCTTTAATATTTTA
TTACAAGTCTTAGATGATGGCCATTTAACGGATGCCAAAGGACGAAAAGTCGATTTTCGTAACACGATTTTAATCATGAC
CTCCAATTTAGGGGCAACAGCGATTCGTGAAGAAAAACATGTTGGCTTCAATGTGAAAGACATTTCTAAAAATCATGAAT
TAATGCAAAAACGAATCATGGAAGAATTGAAAAAAGCCTTCCGTCCAGAATTCTTAAACCGAATTGATGAAACGGTTGTA
TTCCATTCCTTGAAACAAGAGGAAATTCATGAAATCGTAAAAATTATGAGTCAATCTGTCGTGAAACGGATGGCTGAACA
AGAGGTTAAAGTGAAAATCACACCAGCTGCAATTGAAGTTATTGGTAAAGTCGGGTTTGATCCAGAATATGGCGCACGTC
CAATTCGTCGGGCCTTGCAAAAAGAAGTGGAAGATCGTTTAAGTGAAGCCCTTCTTTCTGGTCAAATTCAGTTAGGGGAT
AAAGTAACTTTAGGCGCTAGCAAAGGCAAAATTACGTTAAATGTGCGGGCACCAAAAGCACCAAAGACAGAAGCGAAAGA
ATTACAAACTGTATAG

Protein sequence :
MDELFTESAKAVLAIAQEEAKYFRHQSVGSEHLLLALVLEPNGIAGKTLRQLNTDTEDIREEIEHLSGYGTMQSPMGNNN
LYLPYSPRAKQIFAYAGDEAKRLGAQKIGTEHLLLGLLRDEEILASRILVNLGLSLSKMRQLLLKKMGVSEPNGAQRRRN
GQNKNAPQGTPTLDSLARDLTKLAREQSLDPVVGRGTEVRRLIQILSRRTKNNPVLVGEPGVGKTAIAEGLAQKIVNREV
PEDMQGKRLMMLDMGALVAGTKYRGEFEDRLKKVVDEIYQDGQVILFIDELHTLIGAGGAEGAIDASNILKPALARGELQ
TIGATTLDEYQKYIEKDAALERRFARIQVAEPTPEEAEEILKGLRSRYEKHHGVEITDEALHAAVQLSIRYLNDRQLPDK
AIDLMDESAAKVRLDKADQPSEINELRTEISQLITEKEEAIQNQSFESAARIRQKEKQVMEKLEELIAVKEKSLSGYSTQ
VTEEDVAGVVSQWTGVPLQQLEKKESERLMELETILHQRVVGQNEAVEAVSRAIRRARSGLKDPARPIGSFMFLGPTGVG
KTELAKALAEAMFGSEEALIRVDMSEFMEKYSTSRLIGSPPGYVGYEEGGQLTEKIRQRPYSVILLDEVEKAHPDVFNIL
LQVLDDGHLTDAKGRKVDFRNTILIMTSNLGATAIREEKHVGFNVKDISKNHELMQKRIMEELKKAFRPEFLNRIDETVV
FHSLKQEEIHEIVKIMSQSVVKRMAEQEVKVKITPAAIEVIGKVGFDPEYGARPIRRALQKEVEDRLSEALLSGQIQLGD
KVTLGASKGKITLNVRAPKAPKTEAKELQTV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 51
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 3e-97 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpC NP_816879.1 ATP-dependent Clp protease, ATP-binding protein ClpC VFG0079 Protein 0.0 61
clpC NP_816879.1 ATP-dependent Clp protease, ATP-binding protein ClpC VFG0080 Protein 7e-150 49
clpC NP_816879.1 ATP-dependent Clp protease, ATP-binding protein ClpC VFG2084 Protein 5e-98 41