Gene Information

Name : thyA (EF1576)
Accession : NP_815293.1
Strain : Enterococcus faecalis V583
Genome accession: NC_004668
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 1529048 - 1529995 bp
Length : 948 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGGAAGAAGCATACTTAGCGCTAGGAAAAAAGATTTTAGAAGAAGGTCATTTTAAAGAAGACCGTACAGGAACTGGGAC
GTATAGTTTATTTGGCTATCAAATGCGTTTTGATTTGGCCAAAGGATTTCCCTTACTAACAACCAAACGAGTACCGTTTG
GCTTGATTAAAAGTGAGTTATTGTGGTTTTTAAAAGGCGACACGAATATTCGCTATTTGTTAGAGCGAAATAATCATATT
TGGGATGAATGGGCGTTCGAACGTTACGTAAAAAGCGCAGATTATCAAGGACCAGACATGACGGATTTTGGGCATCGTGT
CTTACAAGATCCAGCGTTTGCAGAACAATACAAAGAAGAACATCAAAAATTCTGTGATGCCATTTTAAATGATGCAGAGT
TTGCAGAAAAATATGGTGAATTAGGGAATATTTATGGTGCACAATGGCGTCACTGGGAAACCAAAGATGGTAGCTTTATC
GATCAATTAGCTAATGTGATTGAAATGATTAAAACCAATCCTGATTCTCGCCGTTTAATTGTTTCCGCTTGGAATCCAGA
AGATGTGCCTTCAATGGCGTTGCCGCCTTGTCACACTATGTTTCAATTTTATGTAAATGAAGGAAAATTAAGCTGTCAAC
TTTATCAGCGCAGTGCCGATGTTTTTTTAGGTGTTCCTTTTAACATTGCAAGCTATGCTTTATTGACACATCTGATTGCG
CATGAAACAGGTTTAGAAGTGGGGGAGTTTGTACACACGCTAGGAGATGCCCACTTATATCAAAATCATGTGGAACAAAT
GCAAGAACAATTATCACGAGAAGTTCGTTCTTTCCCAACGCTCGTTTTGAATCCAGACAAGGCTTCTGTTTTTGATTTTG
ATATGGAAGATATTAAAGTAGAAGGCTATGACCCACATCCAACGATTAAAGCGCCGATTGCCGTATAA

Protein sequence :
MEEAYLALGKKILEEGHFKEDRTGTGTYSLFGYQMRFDLAKGFPLLTTKRVPFGLIKSELLWFLKGDTNIRYLLERNNHI
WDEWAFERYVKSADYQGPDMTDFGHRVLQDPAFAEQYKEEHQKFCDAILNDAEFAEKYGELGNIYGAQWRHWETKDGSFI
DQLANVIEMIKTNPDSRRLIVSAWNPEDVPSMALPPCHTMFQFYVNEGKLSCQLYQRSADVFLGVPFNIASYALLTHLIA
HETGLEVGEFVHTLGDAHLYQNHVEQMQEQLSREVRSFPTLVLNPDKASVFDFDMEDIKVEGYDPHPTIKAPIAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 7e-103 68