Gene Information

Name : thyA (BT_2047)
Accession : NP_810960.1
Strain : Bacteroides thetaiotaomicron VPI-5482
Genome accession: NC_004663
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 2568918 - 2569712 bp
Length : 795 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAAACAATATTTAGATTTACTCAATCGCGTATTAACTGAAGGAACTGAGAAAAGTGACCGTACAGGAACCGGAACGAT
CAGTGTGTTCGGACATCAGATGCGTTTCAACCTCGACGAGGGTTTCCCGTGTCTGACCACCAAAAAACTGCATCTGAAAT
CAATCATCTACGAGTTACTCTGGTTTCTGCAAGGTGATACGAACGCGAAATATCTGCAAGAACACGGTGTACGCATCTGG
AACGAATGGGCGGACGAGAACGGTGATTTAGGGCATATCTATGGCTATCAGTGGCGTTCGTGGCCCGACTACGACGGCGG
ATTCATCGACCAGATCAGCGAAGCGGTAGAGACGATCAAGCACAATCCCGACTCCCGCCGTATCATTGTCAGCGCCTGGA
ATGTAGCCGATTTAAAGAATATGAACCTGCCTCCCTGTCATGCCTTCTTCCAGTTTTACGTGGCAGACGGTCGGCTGAGC
CTGCAACTTTACCAGCGCAGCGCGGATATATTTCTCGGAGTCCCGTTCAATATCGCATCATATGCACTGCTGCTACAAAT
GATGGCGCAGGTGACAGGACTGAAAGCGGGTGAATTTATCCATACACTTGGCGATGCCCATATCTATCTGAACCACTTGG
ATCAGGTCAAATTGCAGCTTAGCCGCGAACCACGCGCATTGCCTCAAATGAAAATTAATCCGGATGTGAAGAGTATCTAT
GACTTCCAGTTCGAAGACTTCGAACTGGTGAACTACGACCCGCATCCACATATTGCCGGAATAGTAGCGGTATAA

Protein sequence :
MKQYLDLLNRVLTEGTEKSDRTGTGTISVFGHQMRFNLDEGFPCLTTKKLHLKSIIYELLWFLQGDTNAKYLQEHGVRIW
NEWADENGDLGHIYGYQWRSWPDYDGGFIDQISEAVETIKHNPDSRRIIVSAWNVADLKNMNLPPCHAFFQFYVADGRLS
LQLYQRSADIFLGVPFNIASYALLLQMMAQVTGLKAGEFIHTLGDAHIYLNHLDQVKLQLSREPRALPQMKINPDVKSIY
DFQFEDFELVNYDPHPHIAGIVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 1e-80 65