Gene Information

Name : sirA (t0929)
Accession : NP_804757.1
Strain : Salmonella enterica Ty2
Genome accession: NC_004631
Putative virulence/resistance : Virulence
Product : response regulator
Function : -
COG functional category : T : Signal transduction mechanisms
COG ID : COG2197
EC number : -
Position : 1023352 - 1024008 bp
Length : 657 bp
Strand : +
Note : in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate v

DNA sequence : 
TTGATCAACGTTCTTCTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTTGAAGATATAAAGGGCAT
TAAAGTTGTCGGTGAAGCGTGCTGCGGAGAGGATGCGGTAAAATGGTGCCGTACTAACGCCGTTGACGTCGTGCTGATGG
ATATGAACATGCCCGGTATTGGCGGCCTTGAGGCGACGCGTAAAATTGCCCGATCGACAGCGGATATCAAAGTGATCATG
CTGACCGTCCATACGGAGAACCCGTTGCCCGCCAAAGTGATGCAGGCTGGCGCAGCTGGCTATCTCAGCAAAGGCGCTGC
GCCTCAGGAGGTGGTGAGCGCTATTCGTTCGGTGTATTCCGGACAACGTTATATCGCCTCCGATATCGCTCAACAGATGG
CGCTCAGTCAGATTGAGCCTGCAAAAACGGAAACGCCGTTCGCCAGTTTGTCTGAACGCGAGTTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATTTCAGAACAGCTGAATCTCAGTCCTAAAACGGTGAACAGCTATCGCTATCG
TATGTTCAGTAAATTAAACATTCATGGTGATGTTGAGCTGACTCACCTGGCAATCCGCCATGGCCTGTGTAATGCGGAGA
CGTTAACAAGCCAGTGA

Protein sequence : 
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRTNAVDVVLMDMNMPGIGGLEATRKIARSTADIKVIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPAKTETPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLTSQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00302 YP_008207767.1 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Not tested AbaR25 Protein 2e-46 49
BJAB0868_00306 YP_008211632.1 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Not tested AbaR26 Protein 2e-46 49

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
sirA NP_804757.1 response regulator VFG1889 Protein 1e-54 51