Gene Information

Name : guaA (t0347)
Accession : NP_804218.1
Strain : Salmonella enterica Ty2
Genome accession: NC_004631
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 415601 - 417178 bp
Length : 1578 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACGGAAAACATTCATAAGCATCGCATCCTCATTCTGGACTTCGGTTCTCAGTACACTCAACTGGTTGCGCGCCGCGT
GCGTGAGCTGGGTGTTTACTGCGAACTGTGGGCGTGGGATGTGACAGAAGCACAAATTCGTGACTTCAACCCAAGCGGCA
TTATTCTTTCCGGCGGCCCGGAAAGCACCACCGAAGAAAACAGCCCGCGCGCGCCGCAGTATGTCTTTGAAGCAGGCGTG
CCGGTATTTGGCGTCTGCTACGGGATGCAGACCATGGCGATGCAGCTTGGCGGTCATGTAGAAGGTTCTAATGAGCGTGA
ATTTGGTTACGCGCAGGTCGAAGTGCTGACCGACAGCGCGCTGGTTCGCGGTATTGAAGATTCCCTGACCGCCGACGGCA
AACCGCTGCTGGACGTGTGGATGAGCCACGGCGATAAAGTGACGGCGATTCCGTCCGACTTCGTGACCGTAGCCAGCACC
GAAAGCTGCCCGTTCGCCATCATGGCTAACGAAGAAAAACGCTTCTACGGCGTACAGTTCCACCCGGAAGTGACTCACAC
CCGCCAGGGTATGCGCATGCTGGAGCGTTTTGTGCGTGATATCTGCCAGTGTGAAGCCCTGTGGACGCCGGCGAAGATCA
TCGACGACGCCGTGGCGCGCATTCGCGAGCAGGTAGGCGACGATAAAGTGATCCTCGGTCTCTCCGGCGGCGTGGATTCT
TCCGTAACCGCAATGCTGCTGCACCGCGCGATCGGTAAAAATCTGACCTGTGTATTCGTCGACAACGGCCTGCTGCGTCT
CAACGAAGCCGAGCAGGTGATGGACATGTTTGGCGACCATTTTGGTCTGAACATCGTTCACGTACCGGCAGAAGATCGCT
TCCTGTCCGCGTTGGCTGGCGAAAACGATCCGGAAGCGAAGCGTAAGATCATTGGCCGTGTTTTTGTGGAAGTGTTCGAC
GAAGAAGCGTTGAAACTGGAAGACGTGAAATGGCTGGCGCAGGGCACCATCTACCCTGACGTCATCGAATCTGCGGCGTC
TGCAACCGGTAAAGCGCACGTCATCAAATCTCACCACAATGTTGGCGGCCTGCCGAAAGAGATGAAGATGGGGCTGGTTG
AACCGCTGAAAGAGCTGTTCAAAGACGAAGTGCGTAAGATTGGTCTGGAGCTGGGCCTGCCGTACGACATGCTGTACCGT
CATCCGTTCCCGGGGCCGGGCCTCGGCGTACGTGTACTGGGTGAAGTGAAGAAAGAGTACTGCGACCTGCTGCGCCGTGC
TGATGCCATCTTCATTGAAGAGCTGCGTAAGGCGGATCTGTACGACAAAGTCAGCCAGGCGTTCACCGTCTTCCTGCCAG
TACGCTCCGTTGGCGTAATGGGCGATGGTCGTAAGTACGATTGGGTGGTCTCTCTGCGTGCTGTCGAAACCATCGACTTT
ATGACCGCGCACTGGGCGCACCTGCCGTATGACTTCCTGGGTCGTGTTTCCAACCGCATCATCAATGAAGTCAACGGGAT
TTCCCGTGTGGTGTATGACATCAGCGGTAAACCACCGGCTACCATTGAGTGGGAATAA

Protein sequence :
MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSPRAPQYVFEAGV
PVFGVCYGMQTMAMQLGGHVEGSNEREFGYAQVEVLTDSALVRGIEDSLTADGKPLLDVWMSHGDKVTAIPSDFVTVAST
ESCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDS
SVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVMDMFGDHFGLNIVHVPAEDRFLSALAGENDPEAKRKIIGRVFVEVFD
EEALKLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRKADLYDKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 7e-128 51
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 6e-128 51
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-127 51
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-110 48