Gene Information

Name : iagA (t2778)
Accession : NP_806479.1
Strain : Salmonella enterica Ty2
Genome accession: NC_004631
Putative virulence/resistance : Virulence
Product : invasion protein regulator
Function : -
COG functional category : K : Transcription
COG ID : COG3710
EC number : -
Position : 2857723 - 2859384 bp
Length : 1662 bp
Strand : +
Note : Activates the expression of invasion genes and activates the expression of prgHIJK which is part of the pathogenicity island 1 type III secretion system

DNA sequence :
ATGCCACATTTTAATCCTGTTCCTGTATCGAATAAAAAATTCGTCTTTGATGATTTCATACTCAACATGGACGGCTCCCT
GCTACGCTCAGAAAAGAAAGTCAATATTCCGCCAAAAGAATATGCCGTTCTGGTCATCCTGCTCGAAGCCGCCGGCAAGA
TTGTGAGTAAAAACACCTTATTGGACCAAGTATGGGGCGACGCGGAAGTTAACGAAGAATCTCTTACCCGCTGTATCTAT
GCCTTACGACGTATTCTGTCGGAAGATAAAGAGCATCGTTACATTGAAACACTGTACGGACAGGGTTATCGGTTTAATCG
TCCGGTCGTAGTGGTGTCTCCGCCAGCGCCGCAACCTACGACTCATACATTGGCGATACTTCCTTTTCAGATGCAGGATC
AGGTTCAATCCGAGAGTCTGCATTACTCTATCGTGAAGGGATTATCGCAGTATGCGCCCTTTGGCCTGAGCGTGCTGCCG
GTGACCATTACGAAGAACTGCCGCAGTGTTAAGGATATTCTTGAGCTCATGGATCAATTACGCCCCGATTATTATATCTC
CGGGCAGATGATACCCGATGGTAATGATAATATTGTACAGATCGAGATAGTTCGGGTTAAAGGTTATCACCTGCTGCACC
AGGAAAGCATTAAGTTGATAGAACACCAACCCGCTTCTCTCTTGCAAAACAAAATTGCGAATCTTTTGCTCAGATGTATT
CCCGGACTTCGCTGGGACACAAAGCAAATTAGCGAGCTAAATTCGATTGACAGTACCATGGTCTACTTACGCGGTAAGCA
TGAGTTAAATCAATACACCCCCTATAGCTTACAGCAAGCGCTTAAATTGCTGACTCAATGCGTTAATATGTCGCCAAACA
GCATTGCGCCTTACTGTGCGCTGGCAGAATGCTACCTCAGCATGGCGCAAATGGGGATTTTTGATAAACAAAACGCAATG
ATCAAAGCTAAAGAACATGCGATTAAGGCGACAGAGCTGGACCACAATAATCCACAAGCTTTAGGATTACTGGGGCTAAT
TAATACGATTCACTCAGAATACATCGTCGGGAGTTTGCTATTCAAACAAGCTAACTTACTTTCGCCCATTTCTGCAGATA
TTAAATATTATTATGGCTGGAATCTTTTCATGGCTGGTCAGTTGGAGGAGGCCTTACAAACGATTAACGAGTGTTTAAAA
TTGGACCCAACGCGCGCAGCCGCAGGGATCACTAAGCTGTGGATTACCTATTATCATACCGGTATTGATGATGCTATACG
TTTAGGCGATGAATTACGCTCACAACACCTGCAGGATAATCCAATATTATTAAGTATGCAGGTTATGTTTCTTTCGCTTA
AAGGTAAACATGAACTGGCACGAAAATTAACTAAAGAAATATCCACGCAGGAAATAACAGGACTTATTGCTGTTAATCTT
CTTTACGCTGAATATTGTCAGAATAGTGAGCGTGCCTTACCGACGATAAGAGAATTTCTGGAAAGTGAACAGCGTATAGA
TAATAATCCGGGATTATTACCGTTAGTGCTGGTTGCCCACGGCGAAGCTATTGCCGAGAAAATGTGGAATAAATTTAAAA
ACGAAGACAATATTTGGTTCAAAAGATGGAAACAGGATCCCCGCTTGATTAAATTACGGTAA

Protein sequence :
MPHFNPVPVSNKKFVFDDFILNMDGSLLRSEKKVNIPPKEYAVLVILLEAAGKIVSKNTLLDQVWGDAEVNEESLTRCIY
ALRRILSEDKEHRYIETLYGQGYRFNRPVVVVSPPAPQPTTHTLAILPFQMQDQVQSESLHYSIVKGLSQYAPFGLSVLP
VTITKNCRSVKDILELMDQLRPDYYISGQMIPDGNDNIVQIEIVRVKGYHLLHQESIKLIEHQPASLLQNKIANLLLRCI
PGLRWDTKQISELNSIDSTMVYLRGKHELNQYTPYSLQQALKLLTQCVNMSPNSIAPYCALAECYLSMAQMGIFDKQNAM
IKAKEHAIKATELDHNNPQALGLLGLINTIHSEYIVGSLLFKQANLLSPISADIKYYYGWNLFMAGQLEEALQTINECLK
LDPTRAAAGITKLWITYYHTGIDDAIRLGDELRSQHLQDNPILLSMQVMFLSLKGKHELARKLTKEISTQEITGLIAVNL
LYAEYCQNSERALPTIREFLESEQRIDNNPGLLPLVLVAHGEAIAEKMWNKFKNEDNIWFKRWKQDPRLIKLR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
iagA NP_457270.1 invasion protein regulator Not tested SPI-1 Protein 0.0 100
iagA NP_806479.1 invasion protein regulator Virulence SPI-1 Protein 0.0 100
hilA YP_217795.1 invasion protein regulator Virulence SPI-1 Protein 0.0 99
hilA NP_461797.1 invasion protein regulator Virulence SPI-1 Protein 0.0 99

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
iagA NP_806479.1 invasion protein regulator VFG0538 Protein 0.0 99