Gene Information

Name : entE (t2272)
Accession : NP_806014.2
Strain : Salmonella enterica Ty2
Genome accession: NC_004631
Putative virulence/resistance : Virulence
Product : enterobactin synthase subunit E
Function : -
COG functional category : -
COG ID : -
EC number : 2.7.7.58
Position : 2337933 - 2339543 bp
Length : 1611 bp
Strand : -
Note : 'bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate

DNA sequence : 
ATGCGTATACCTTTCACCCGTTGGCCGGATGAATTTGCCCGCCGTTATCGTGAAAAAGGCTACTGGCAAGACGTGCCGTT
GACCGATATTCTGACCCGCCACGCTGACAGCGATAAGACGGCGGTCATTGAAGGCGAGCGCGCATTCAGCTATCGCCAGC
TAAACCAGGCCGCGGATAATCTGGCCTGCAGTTTACGCCGTCAGGGCATCAAACCTGGCGAAACCGCTCTGGTACAACTG
GGGAATGTACCGGAACTGTATATCACCTTTTTCGCCCTGTTGAAGCTTGGCGTAGCGCCCGTTCTGGCGCTGTTTAGCCA
TCAACGTACCGAACTTAACGCCTATGCGATGCAGATCGCGCCGACGCTGGTGATTGCCGATCGCCAACATACGCTGTTCG
CCGGGGAGGACTTTCTCAACAGGTTTGTGGCTGAACACCGCTCTGCGCGGGTGGTGTTATTGCGCAACGACGACGGCGAT
CACAGCCTGGACGCGGCGATGCGGCAGGCGGCGGAAGGTTTCACCGCCACGCCATCACCTGCTGACGAAGTGGCCTACTT
TCAGCTTTCCGGCGGTACTACCGGCACGCCAAAGCTTATTCCCCGTACCCATAACGACTATTACTACAGCGTGCGCCGCA
GCAATGAGATTTGCGGTTTCAACGAGGAGACGCGTTTTCTGTGCGCGATTCCCGCCGCGCATAACTACGCCATGAGTTCG
CCGGGCGCGCTGGGCGTTTTTCTCGCCAAAGGAACGGTAGTGCTGGCGACCGATCCTGGCGCCACGCTCTGTTTCCCGCT
GATCGAAAAACACCAGATTAATGCCACGGCGCTGGTGCCGCCCGCGGTCAGTCTATGGCTACAGGCTATCCAGGAGTGGG
GCGGCAATGCGCCGCTGGCGTCATTAAGGTTATTGCAGGTTGGCGGCGCGCGGCTTTCTGCGACGCTGGCCGCCCGTATT
CCGGCTGAAATTGGCTGTCAGTTGCAGCAGGTCTTCGGCATGGCGGAAGGGTTAGTGAACTATACCCGGCTGGACGATAG
CCCGGAACGGATTATCAATACCCAGGGAAGACCCATGTGTCCGGACGACGAAGTGTGGGTGGCGGATGCCGACGGGAATC
CACTGCCGCCGGGCGAGATTGGTCGTCTGATGACGCGCGGCCCCTATACTTTTCGCGGCTATTTCAACAGTCCGCAACAC
AATGTCAGCGCCTTTGACGCCAACGGTTTTTACTGTTCCGGCGATCTGATCTCCATTGATCAAGACGGCTACATCACCGT
TCACGGGCGTGAAAAAGATCAGATCAACCGGGGCGGCGAGAAGATAGCCGCCGAAGAGATAGAAAACCTGTTACTGCGCC
ACCCGGCGGTGATCCATGCGGCGCTGGTCAGCATGGAAGATGAACTGCTGGGGGAAAAAAGTTGCGCATATCTGGTGGTA
AAAGAGCCGCTGCGAGCGGTACAGGTACGCCGTTTCCTGCGAGAGCAGGGCGTGGCGGAATTTAAATTACCGGATCGCGT
GGAGTGCGTTGCGTCACTGCCGCTGACGCCGGTTGGTAAAGTCGATAAAAAACAATTACGCCAGCGGTTGGCGTCACGTT
CACCGCTCTGA

Protein sequence : 
MRIPFTRWPDEFARRYREKGYWQDVPLTDILTRHADSDKTAVIEGERAFSYRQLNQAADNLACSLRRQGIKPGETALVQL
GNVPELYITFFALLKLGVAPVLALFSHQRTELNAYAMQIAPTLVIADRQHTLFAGEDFLNRFVAEHRSARVVLLRNDDGD
HSLDAAMRQAAEGFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSNEICGFNEETRFLCAIPAAHNYAMSS
PGALGVFLAKGTVVLATDPGATLCFPLIEKHQINATALVPPAVSLWLQAIQEWGGNAPLASLRLLQVGGARLSATLAARI
PAEIGCQLQQVFGMAEGLVNYTRLDDSPERIINTQGRPMCPDDEVWVADADGNPLPPGEIGRLMTRGPYTFRGYFNSPQH
NVSAFDANGFYCSGDLISIDQDGYITVHGREKDQINRGGEKIAAEEIENLLLRHPAVIHAALVSMEDELLGEKSCAYLVV
KEPLRAVQVRRFLREQGVAEFKLPDRVECVASLPLTPVGKVDKKQLRQRLASRSPL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 1e-88 41
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 2e-88 41
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 1e-88 41
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-88 41
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-88 41
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 1e-88 41
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-88 41
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-88 41
ybtE CAA21394.1 - Virulence HPI Protein 1e-88 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
entE NP_806014.2 enterobactin synthase subunit E VFG0932 Protein 0.0 86
entE NP_806014.2 enterobactin synthase subunit E VFG0168 Protein 1e-115 46
entE NP_806014.2 enterobactin synthase subunit E VFG1817 Protein 2e-89 42