Gene Information

Name : SPs1859 (SPs1859)
Accession : NP_803121.1
Strain : Streptococcus pyogenes SSI-1
Genome accession: NC_004606
Putative virulence/resistance : Unknown
Product : rRNA large subunit methyltransferase
Function : -
COG functional category : S : Function unknown
COG ID : COG1576
EC number : -
Position : 1891496 - 1891975 bp
Length : 480 bp
Strand : -
Note : SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA

DNA sequence :
ATGAAAGTAAAACTAATTTGTGTTGGAAAACTAAAAGAAAGATACCTCAAAGATGGTATTTCAGAATATCAAAAAAGACT
TTCCCGTTTTTGTCAATTCGAAATGATTGAGTTAACTGATGAAAGAACACCAGATAAAGCAAGTTTTGCTGATAATCAAT
TGATTATGAGTAAAGAAGCTCAGCGAATCCATAAAAAAATTGGAGAACGTGATTTTGTAATTGCATTAGCTATTGAAGGA
AAACAGTTTCCTTCAGAGACATTTAGTGAATTAATATCAGGGGTTACTGTTAAGGGATATTCAACTATCACGTTTATTAT
TGGTGGAAGTCTTGGGTTAGATTCAATTATTAAAAAAAGAGCTAATATGCTAATGAGTTTTGGATTGTTAACCTTACCTC
ATCAGTTAATGCGTCTAGTTCTTACTGAGCAAATTTATCGTGCTTTTATGATTACAAAAGGCAGTCCTTATCATAAGTAA

Protein sequence :
MKVKLICVGKLKERYLKDGISEYQKRLSRFCQFEMIELTDERTPDKASFADNQLIMSKEAQRIHKKIGERDFVIALAIEG
KQFPSETFSELISGVTVKGYSTITFIIGGSLGLDSIIKKRANMLMSFGLLTLPHQLMRLVLTEQIYRAFMITKGSPYHK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
orfX YP_251938.1 rRNA large subunit methyltransferase Not tested SCCmec Protein 1e-27 46
SE0023 NP_763578.1 rRNA large subunit methyltransferase Not tested SCCpbp4 Protein 9e-28 45
SERP2529 YP_190070.1 rRNA large subunit methyltransferase Not tested Type-II SCCmec Protein 9e-28 45
unnamed BAC67575.1 open reading frame X Not tested Type-IVc SCCmec Protein 6e-28 44
orfXhom BAB83497.1 open reading frame X Not tested SCC 12263 Protein 5e-25 44
unnamed BAA82243.1 orfX Not tested Type-II SCCmec Protein 6e-28 44
orfX AAL26648.1 unknown Not tested SCCcap1 Protein 5e-27 44
unnamed BAD24821.1 conserved hypothetical protein orfX Not tested Type-V SCCmec Protein 6e-28 44
orfX BAA86653.1 open reading frame X Not tested Type-I SCCmec Protein 6e-28 44
unnamed BAG06184.1 conserved hypothetical protein orfX Not tested Type-VII SCCmec Protein 6e-28 44
unnamed BAB47681.1 open reading frame X Not tested Type-III SCCmec Protein 6e-28 44
SSP0026 YP_300116.1 rRNA large subunit methyltransferase Not tested SCC15305RM Protein 1e-27 44
unnamed BAC53844.1 open reading frame X Not tested SRImec-III and SCCmec-III region Protein 6e-28 44
unnamed BAC57492.1 hypothetical protein Not tested Type-IIIinv SCCmec Protein 6e-28 44
unnamed BAB72121.1 hypothetical protein Not tested Type-IVa SCCmec Protein 6e-28 44
SAR0024 YP_039501.1 rRNA large subunit methyltransferase Not tested Type-II SCCmec Protein 9e-28 44
unnamed BAB72138.1 open reading frame X Not tested Type-IVb SCCmec Protein 6e-28 44
SAV0024 NP_370548.1 rRNA large subunit methyltransferase Not tested Type-II SCCmec Protein 9e-28 44