Gene Information

Name : smpB (CTC00385)
Accession : NP_781085.1
Strain : Clostridium tetani E88
Genome accession: NC_004557
Putative virulence/resistance : Unknown
Product : SsrA-binding protein
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0691
EC number : -
Position : 379026 - 379496 bp
Length : 471 bp
Strand : +
Note : binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Ca

DNA sequence :
ATGGTCAAAGGTAGAAGCAATAAAACTCTTGCAGAAAATAGAAAAGCAAGACATGATTACTTTGTAGAAGAAGCTTATGA
AGCAGGAATAGAGTTAGTTGGTACAGAAGTAAAATCTATAAGGGAAGGCAAAGCCAATTTAAAGGATAGTTATGCAGAAA
TAAGAAATGGAGAAGTTTTTCTTAGGAATATGCATGTAAGTCCTTATGAACAGGGTAATATTTTCAATAAAGATCCATTA
AGGGATAGAAAATTATTACTACATAAAATGCAAATTTTAAAGCTAACAGCCTATACTACTCAACAAGGATATACTTTAAT
ACCATTATCATTATATCTTAAAAATGGTAGAGTTAAAGTAAATTTAGCTGTAGCTAAAGGTAAAAAGAACTATGATAAAA
GACAAGATTTAATAGAAAAAGCAGCTAAACGCGATATTGAAAGAGAATTAAAAGATAGAAGTAGGTATTAA

Protein sequence :
MVKGRSNKTLAENRKARHDYFVEEAYEAGIELVGTEVKSIREGKANLKDSYAEIRNGEVFLRNMHVSPYEQGNIFNKDPL
RDRKLLLHKMQILKLTAYTTQQGYTLIPLSLYLKNGRVKVNLAVAKGKKNYDKRQDLIEKAAKRDIERELKDRSRY

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed AET14351.1 SsrA-binding protein Not tested SaPI68111 Protein 1e-43 66
smpB YP_001800894.1 SsrA-binding protein Not tested Not named Protein 2e-34 51
smpB NP_230495.1 SsrA-binding protein Not tested VPI-1 Protein 5e-28 46