Gene Information

Name : mecB (CTC02633)
Accession : NP_783145.1
Strain : Clostridium tetani E88
Genome accession: NC_004557
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence mecB/clpC
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 2779669 - 2782104 bp
Length : 2436 bp
Strand : -
Note : -

DNA sequence :
TTGATATTTGGAAGATTTAATGAAAGAGCTCAAAAAGTTTTGGTTTTTGCACAAGAATCTGCTAGGAATTATAGACATGG
TTATGTAGGAACAGAACACATATTATTAGGTATATTAAAAGAAGAAGGAATATCCAAAAACATATTAAAGGATATGAATG
TAGAGTTAGAAGATGTAGAAAGTTTAATTGAAGAGTATGAAGGAAAAGGCGACTTAGATTTATACAGTAATGAAATACCT
TTGACACCAAGAACTAAAAGGTTGTTAGAGATAAGTTTATTAGAAGCTAGAAATTTAAATCATAATTTTATAACTCCAGA
ACATATTTTACTTGCTTTAATAAAAGAGTCAGAAGGAATTGCTTTTACTATATTAAGCAATTTAGGAGTTGATTTTAACA
GACTAAGAAAAGAGTTATTAGAGAATGTAGCAGGAGAACGAAGTGTTAATAGATCCAGTAGTGATACTAATAAAAAGAAT
CAAGACACTCCAACATTAAATGAGTTTGGAAGAGATTTAACGGATATGGCCATGGAAGGAAAATTAGATCCTGTAATAGG
AAGAGATAAAGAAACTCAAAGGGTACTACAAATATTGTGTAGAAGAACAAAAAATAACCCTTGTTTAATTGGAGATCCAG
GGGTAGGAAAAACAGCTATCGCAGAAGGATTAGCACAGAAAATAGTTGAAGGAAATATTCCAGAAATTTTAAAAGATAAA
AGGGTTGTAACTTTAGATCTGTCTTCAATGATTGCAGGTGCAAAGTATAGAGGTGAATTTGAAGATAGGTTAAAAAAGGT
TATGGAGGAGATTAGAAAATCTGGTAATGTTATTTTATTTATAGATGAAATTCATACAATTATAGGGGCTGGTGCTGCGG
AAGGAGCAATAGATGCATCAAACATATTAAAGCCCGCTCTAGCTAGAGGGGAAATACAATGTATAGGGGCAACTACTATA
GATGAATACAGAAAACATATTGAGAAAGATTCCGCATTAGAAAGAAGATTCCAACCTATTACAGTGGGAGAACCTACAAA
AGAGGAAGCAATACTTATACTAAGAGGACTAAGAGATAAATATGAGGCTCATCATAGAGCTAATATAACAGACGAAGCTA
TTGAAGCGGCAGTAAACTTATCAGATAGATATATAACTGAAAGATATTTACCAGATAAAGCTATTGATTTAATGGATGAG
GCAGCTTCTAAAGTAAGAATTGAAAATATGATAGCACCTACAGATATGAAAGAATTAGAAGAAAATTTAGAAAAAGTAAC
TAAAGAAAAAGAAGATGCTATAAGAGTGCAAGATTTTGAAAAAGCTGCTCAATTAAGAGACCATGAAAAAGATTTAAAAT
ATAGATTAGAAAATCTAAAATCAGATTGGAAAACTCAAAAGCAAGTAGCTACATTAACTGTAGATGAAACACAAATAGCA
GCGGTAGTTTCTAAATGGACTAATATACCTGTTAGAAAACTTACTGAAAAGGAATCAGAAAGACTTTTAAAATTAGAAGA
AACTTTACACAACAGAGTTATAGGACAAAATGAAGCAGTAAAATCTGTATCAAGAGCTGTTAGAAGAGCAAGAGTTGGAT
TAAAGGATCCTAATAGACCTATAGGTTCATTTATATTCTTAGGTCCAACAGGAGTAGGAAAGACAGAGTTATCTAAAGCA
TTAGCGGAAGCTATGTTTGGTGATGAAAGTAGTATGATAAGAATAGATATGTCAGAGTACATGGAAAAACATGCAGTATC
AAGACTCATAGGATCACCTCCAGGTTATGTTGGATATGATGAAGGTGGTCAATTAACAGAGAAGGTAAGAAGACATCCTT
ATTCAGTAATATTATTTGATGAAATAGAAAAAGCCCATCCAGATGTATTTAATATACTGTTACAAATATTAGAAGATGGA
AGGCTTACAGATGGAAAAGGTAAAACTGTAAATTTTAAGAACACAATAATTATAATGACTTCAAATGTGGGAGCGTCAAC
TATTAAAAAACAAAAGTCATTAGGATTTGCTATAAGTGATGATAAGATTGAAAGTGAATATGAACAAATGAAAGAAAATG
TAATGGAAGAACTAAAAAGATCTTTTAGACCAGAGTTTTTAAATAGAATAGATGATATTATTGTATTCCATAAATTAAGA
GAGGAAGATTTAGAAAAAATAGTAGCTTTGATGTTAGAATCTGTAACTCATAGATTAAAAAATCAAGATATAAATATATC
CTTTGATAAAAAATCACAAAAGTTTCTAGCAAAAAAAGGATTTGATCCAGTTTATGGAGCTAGACCCTTAAGAAGGGCTA
TTACTAAAGCGGTAGAAGATAAATTATCAGAAGAGATATTAAAAGGAAGTATTGAAAAAGGAGATAAAGTATTAGTGTCA
GTCAATGAAGAAAAATTAATATTTAACAAAGAATAA

Protein sequence :
MIFGRFNERAQKVLVFAQESARNYRHGYVGTEHILLGILKEEGISKNILKDMNVELEDVESLIEEYEGKGDLDLYSNEIP
LTPRTKRLLEISLLEARNLNHNFITPEHILLALIKESEGIAFTILSNLGVDFNRLRKELLENVAGERSVNRSSSDTNKKN
QDTPTLNEFGRDLTDMAMEGKLDPVIGRDKETQRVLQILCRRTKNNPCLIGDPGVGKTAIAEGLAQKIVEGNIPEILKDK
RVVTLDLSSMIAGAKYRGEFEDRLKKVMEEIRKSGNVILFIDEIHTIIGAGAAEGAIDASNILKPALARGEIQCIGATTI
DEYRKHIEKDSALERRFQPITVGEPTKEEAILILRGLRDKYEAHHRANITDEAIEAAVNLSDRYITERYLPDKAIDLMDE
AASKVRIENMIAPTDMKELEENLEKVTKEKEDAIRVQDFEKAAQLRDHEKDLKYRLENLKSDWKTQKQVATLTVDETQIA
AVVSKWTNIPVRKLTEKESERLLKLEETLHNRVIGQNEAVKSVSRAVRRARVGLKDPNRPIGSFIFLGPTGVGKTELSKA
LAEAMFGDESSMIRIDMSEYMEKHAVSRLIGSPPGYVGYDEGGQLTEKVRRHPYSVILFDEIEKAHPDVFNILLQILEDG
RLTDGKGKTVNFKNTIIIMTSNVGASTIKKQKSLGFAISDDKIESEYEQMKENVMEELKRSFRPEFLNRIDDIIVFHKLR
EEDLEKIVALMLESVTHRLKNQDINISFDKKSQKFLAKKGFDPVYGARPLRRAITKAVEDKLSEEILKGSIEKGDKVLVS
VNEEKLIFNKE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 54

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
mecB NP_783145.1 negative regulator of genetic competence mecB/clpC VFG0079 Protein 0.0 60
mecB NP_783145.1 negative regulator of genetic competence mecB/clpC VFG0080 Protein 1e-144 50