Gene Information

Name : mecB (CTC00060)
Accession : NP_780779.1
Strain : Clostridium tetani E88
Genome accession: NC_004557
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence mecB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 1 - 2304 bp
Length : 2304 bp
Strand : -
Note : -

DNA sequence :
ATGAAACTATGTTCTGTATGCAATAAAAATGTTGCTACTATTTTTACAACTAGATTTGAAACTGGAAAACCTCAAATTGT
GGGGATATGTGCTGAATGTGCTAAAAAGATGAATATACAGCCTTTAAATCAAATAATTGAAGCTGCAGGAGTAACTCCAG
AGGATATGGAAACTTATGCTGAACAAATGAATAAATTATTAGATAATATGGATATAAACGAACTTTTAAATAACGATTTA
TTTTCTAACATGATTAATAATATGAATGGAATGAATATGTTTAAAGTGCAGGATGATTTCATAGATAAAGATAAGAATGA
GGAAAATACTAATAGTGAAAGAAATAAGGATAAATCAGAAGGTAATTCTAATGTTAAAACAAGAGTCAAATTTAAAAATA
AGAGAAGGAACTTAGATAAATATGCAATAAATTTGAATGATAAGGCAAAGGATAAAAAAATAGATGTTGTAGTAGGTAGA
GACAAGGAAATAGAGAGGATAATTCAAATATTAAATAGAAGAAATAAAAATAATCCTATTCTTATTGGAGAACCTGGAGT
TGGTAAAACAGCTATAGCGGAAGGATTAGCAGTAAAAATAATAGAAAAAAATGTTCCAATAAAATTGTTTGATAAAGAGA
TATATTTATTAGATTTAACTTCTGTAGTGGCAGGAACTCAATTTAGAGGTCAGTTTGAAGGACGCATGAAGGCTATAGTA
GATGAAGTTACAGAAAGTGAAAATGTCATATTAGTTATAGATGAGGTTCATAATATTATAGGAGCTGGGGAAGCTCAAGG
AGGAGCGTTAAATGCTGCAAATATATTGAAGCCGGCTTTAGCTAGAGGAGATATTCAAGTTATTGGAGCTACAACTTTAG
AAGAATATAGAAAATATATAGAAAAAGATTCTGCACTAGAAAGAAGATTTCAGCCAATATTAGTAGAGGAGCCATCAGTT
AAGGAAACCATAGAAATTTTAAATAATATAAAAATATACTATGAGGATTATCATAAAGTTAAAATATCTAAAAAGATTAT
AGAGGAGGCTGTAAAACTATCTGAAAGATATATAACAGATAGGTATTTACCTGACAAAGCTATAGATGTTATAGATGAAG
CTAGTTCTAGAGTTAATTTAAGAAATAAGAATCTAGTAGAATTTAAAATTGCTAAAGAAGAGTTAGGAGAGTTGCAAAAT
AAAATGTTAAATGAAGCTAATAGTGGAAATTATGAAAAAGCAGCTCAATATAAAACAGAGGAATACAAATTAAAGAATAA
AGTTGAAGAATTAGAGAAGAAAAGCAAAGTAGAATTATCAGTAGATGATATAGCGTATGTAATCGAAGCATGGACCAAAA
TACCAGTTCAGAAAGTAAGAGAAAAAGAAGCAGAAAAATTATTAAATCTTGAGCAAAGACTTCATAAGAGATTAATTGGG
CAAGATAAAGCGGTACGTAAACTTTCCAGAACAATAAGAAGAAATAGATTAGGATTTAAAAGTAAAAAAAGACCAGCATC
TTTTATATTTGTAGGACCAACAGGGGTTGGGAAAACAGAACTTGTTAGATCTTTAGCATGTGAATTATTTGGAGATGAAG
ATTCTTTAATAAGAATAGATATGTCAGAATATATGGAAAAGCATACAGCTTCGAAATTAATAGGATCACCTCCTGGATAT
GTAGGATATGATGAAGGTGGGCAATTAACTGAAAAAATTAGAAGAAAACCATATTCAGTTGTCCTTTTGGATGAAATAGA
AAAAGCACATCCAGATATTTTTAATATGCTTTTGCAGGTATTAGAAGACGGAAGATTGACAGATAATCAAGGTAGAACTG
TTTTTTTTGATAACTCTGTAATAATAATGACATCTAATTTGGGTACTAATTTTAAAGAAAGTTCCATAGGCTTCGGAAAT
ACAAATTCTATTCAAATTGAAAATAGTATAAAGGATGCATTAAAAGAAACATTTAAACCAGAATTTATAAATAGAATAGA
TGAGATAGTTATATTTGAAAAATTAAATAAAGAAGAGCTTTATGATATTATAGATATTATGTTTGATGAAGTTTCAGAAG
ATTTAAGTGAAAAAAATATAAAAGTACATTTTACAAAAGAGGTTAAAGATTTTATATTAAAAGTAGGTTATGACGAAAAA
TATGGTGCAAGGGAATTAAAAAGAGCCATACAAAGATATATTGAAGATGAAATATCTGAACAATATTTTAGAAATGAAGT
GAAGGAAGGAACAAATATTTTAGTAGATATATATGAAGAAAGTATATATATAAAGAATATGTAA

Protein sequence :
MKLCSVCNKNVATIFTTRFETGKPQIVGICAECAKKMNIQPLNQIIEAAGVTPEDMETYAEQMNKLLDNMDINELLNNDL
FSNMINNMNGMNMFKVQDDFIDKDKNEENTNSERNKDKSEGNSNVKTRVKFKNKRRNLDKYAINLNDKAKDKKIDVVVGR
DKEIERIIQILNRRNKNNPILIGEPGVGKTAIAEGLAVKIIEKNVPIKLFDKEIYLLDLTSVVAGTQFRGQFEGRMKAIV
DEVTESENVILVIDEVHNIIGAGEAQGGALNAANILKPALARGDIQVIGATTLEEYRKYIEKDSALERRFQPILVEEPSV
KETIEILNNIKIYYEDYHKVKISKKIIEEAVKLSERYITDRYLPDKAIDVIDEASSRVNLRNKNLVEFKIAKEELGELQN
KMLNEANSGNYEKAAQYKTEEYKLKNKVEELEKKSKVELSVDDIAYVIEAWTKIPVQKVREKEAEKLLNLEQRLHKRLIG
QDKAVRKLSRTIRRNRLGFKSKKRPASFIFVGPTGVGKTELVRSLACELFGDEDSLIRIDMSEYMEKHTASKLIGSPPGY
VGYDEGGQLTEKIRRKPYSVVLLDEIEKAHPDIFNMLLQVLEDGRLTDNQGRTVFFDNSVIIMTSNLGTNFKESSIGFGN
TNSIQIENSIKDALKETFKPEFINRIDEIVIFEKLNKEELYDIIDIMFDEVSEDLSEKNIKVHFTKEVKDFILKVGYDEK
YGARELKRAIQRYIEDEISEQYFRNEVKEGTNILVDIYEESIYIKNM

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 4e-150 51

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
mecB NP_780779.1 negative regulator of genetic competence mecB VFG0080 Protein 6e-155 53
mecB NP_780779.1 negative regulator of genetic competence mecB VFG0079 Protein 2e-160 52