Gene Information

Name : clpB (TW758)
Accession : NP_789679.1
Strain : Tropheryma whipplei TW08/27
Genome accession: NC_004551
Putative virulence/resistance : Virulence
Product : heat shock protein ClpB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 854662 - 856761 bp
Length : 2100 bp
Strand : -
Note : Similar to Streptomyces albus G heat shock protein ClpB SWALL:Q9Z6E4 (EMBL:AF076980) (857 aa) fasta scores: E(): 2.9e-134, 59.62% id in 686 aa. Note approx 150 residue N-termunal truncation relative to all homologues.

DNA sequence :
ATGTCTGAATCACAGTCTGAATTAGACAAGTACGGCACGAACCTCACAAAGACTGCGGCAACAAACAAGCTCGATCCGGT
GATAGGCCGCGATGCAGAGATCCGGCGGGTGTGTCAGATTCTCTCCAGACGAACTAAGAATAACCCCGTTCTGATAGGGT
CAGCAGGTGTTGGTAAAACTGCTATAGTTGAGGGCCTTGCGCAGCGTATTGTTGCAGGGGATGTTCCTGAGAGTTTGCGG
AACAAGGAAATAGTTAGTCTCGATTTATCGGCCCTGCTTGCTGGTGCATCTTACAGGGGAGAGTTCGAGAAACGTGTCAA
AAATCTTTTGGAAGAGATACAAAAGTCTAAGGTAATAATCTTCATAGATGAGGTTCACACACTTATGAGTGCCGGCGCAG
CAGAAGGTGCAATTGCGGCGGGTAATATGCTAAAACCCCTTTTGGCTCGAGGGGAACTCAGGCTTATTGGCGCGACCACT
CTGGATGAATATCGTGAGCATTTGGAAAAAGACCCTGCACTGGAAAGACGATTCCAGCAAGTGTTTGTTGGTGAGCCAAA
TCTTGAAGACTGCATAGCGATTATGCGGGGCTTGAAAGAGCGTTACGAGGCTCATCATAAAGTGAGTATATCCGACACAG
CACTTGTGACTGCCGTTGAGTTGTCGAGTCGATATATAACGGGCAGGCAACTTCCTGATAAGGCAATCGACTTGCTCGAC
GAGGCAGCCAGTTCATTGCGCATGGAAATTGATTCATCACCGGTTGAGCTTGATCAGCTTCGTAGGGAGGTTGATCGGTT
GCGACTCGAGGAGTTGGCATTAAAGAGTGAGAATGACCCTACGAGTGAACAACGTCTAAGATCTATAACTAACCAACTTT
CTGGCAAGCAAGAAATGTTGAATACATTACAGGCAAGCTGGAACTCCGAGAGGGCGCGTCTGAATCAGATTGGCGCTTTG
AAGGAGCAGATTGATATTGCGAAACAATCTGCAGATATTGCCCAGCGCGAGGGTCGCCTTGAAGATGCATCACGACTTCT
TTATGCAACAATTCCACAATTGCAGAAAAATTTGGCGGAGAAGTTGGAAGAACAGGACTCTGCCCCGCTTGTCAGTGACC
AGGTAATGCCGGAAGATATTGCGTCTGTTGTTGAGGGATGGACAGGTATTCCTGTAAAAAAGCTTATGCAAAAAGATGCC
AAACAGCTGCTGCATCTTGAGGAGGATTTGTCCAAATCTGTTATAGCCCAGAAGGTAGCCATAGGTGTTATTGCGGATGC
AGTACGGCGTTCGCGCGCGGGACTGTCGGATCCAAACCGACCTTCCGGAACTTTTTTATTTCTCGGCCCAACGGGGGTTG
GAAAAACACAACTGGTTAAAGCTTTAGCATCTTTGTTATACGATGGTGAAATTGTAAGAATTGACATGTCGGAGTATTCA
GAAAAATTCTCTATCTCACGTCTTATTGGCGCTCCCCCGGGGTATATCGGTCATGAAAGCGCTGGACAGCTTACTGAGTC
TGTTAGGCGGCGGCCATATTCAGTTGTATTGTTTGATGAAGCAGAAAAAGCGCATCCTGAGGTTTTTGATATCCTACTGC
AGGTTCTGGATGAAGGACGCCTAACAGACTCTCATGGTCGCACTGTTGACTTTAGAAACACGATTATAGTTTTAACTTCT
AATATAGGCTCGCGTTACCTATCAGACATTTCCCTTGAGGCTACTACAGCGCACGAGTATGTTAATGATGAGGTTCGCAG
AACCTTTCGTCCAGAATTTTTGAACAGACTCGATGAAATTGTTATTTTTGAGCCATTGTCGCAAAGTGATATTTGTCAAA
TTGTTGACCTGAATATAGAATCCCTGAATAAGCGGATCAAGGATAGGCGGATTGTTGTGACAGTCAGTGAGGATTTAAGG
CGTTGGCTGTCAAAGAGCGGCTATGACGTGATTTACGGCGCGCGGCCATTGAGGAGGCTTATTCAGCGTGAGATAGAAGA
TAGACTTGCAAAGTTGATTATAGAGGGTCTTATACATGACGGACAGACTGCGTCTTTTGACCTGTCTGGGGGCGCTGTGA
ATGCCCAGGTGTGCTCCTGA

Protein sequence :
MSESQSELDKYGTNLTKTAATNKLDPVIGRDAEIRRVCQILSRRTKNNPVLIGSAGVGKTAIVEGLAQRIVAGDVPESLR
NKEIVSLDLSALLAGASYRGEFEKRVKNLLEEIQKSKVIIFIDEVHTLMSAGAAEGAIAAGNMLKPLLARGELRLIGATT
LDEYREHLEKDPALERRFQQVFVGEPNLEDCIAIMRGLKERYEAHHKVSISDTALVTAVELSSRYITGRQLPDKAIDLLD
EAASSLRMEIDSSPVELDQLRREVDRLRLEELALKSENDPTSEQRLRSITNQLSGKQEMLNTLQASWNSERARLNQIGAL
KEQIDIAKQSADIAQREGRLEDASRLLYATIPQLQKNLAEKLEEQDSAPLVSDQVMPEDIASVVEGWTGIPVKKLMQKDA
KQLLHLEEDLSKSVIAQKVAIGVIADAVRRSRAGLSDPNRPSGTFLFLGPTGVGKTQLVKALASLLYDGEIVRIDMSEYS
EKFSISRLIGAPPGYIGHESAGQLTESVRRRPYSVVLFDEAEKAHPEVFDILLQVLDEGRLTDSHGRTVDFRNTIIVLTS
NIGSRYLSDISLEATTAHEYVNDEVRRTFRPEFLNRLDEIVIFEPLSQSDICQIVDLNIESLNKRIKDRRIVVTVSEDLR
RWLSKSGYDVIYGARPLRRLIQREIEDRLAKLIIEGLIHDGQTASFDLSGGAVNAQVCS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 2e-90 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpB NP_789679.1 heat shock protein ClpB VFG2076 Protein 4e-107 42
clpB NP_789679.1 heat shock protein ClpB VFG2084 Protein 5e-95 41