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Name : TW075 (TW075) Accession : NP_789025.1 Strain : Tropheryma whipplei TW08/27 Genome accession: NC_004551 Putative virulence/resistance : Virulence Product : Clp-family ATP-binding protease/regulator Function : - COG functional category : O : Posttranslational modification, protein turnover, chaperones COG ID : COG0542 EC number : - Position : 67380 - 69902 bp Length : 2523 bp Strand : + Note : Similar to Bacillus subtilis negative regulator of genetic competence ClpC/MecB SWALL:CLPC_BACSU (SWALL:P37571) (810 aa) fasta scores: E(): 3e-152, 56.66% id in 810 aa, and to Streptomyces coelicolor Vlp-family ATP-binding protease SCO3373 or SCE94.24c SW DNA sequence : TTGGGTGAGGATATGTTTGAAAGGTTTACAGATAAAGCCCGCCGGGTTATAGTACTGGCGCAGGAGGAAGCGCGCACGCT TAGCCACAATTACATTGGCACCGAGCATGTTCTTCTTGGCCTTATTAGCGAGGGTGATGGTATTGCCGCCCAGGCGCTTG AGAGTCTTGATATTACCCTTGAGCGTGCGCGCGAGGGCGTGGCGGAACTAATAGGTCGGGGTCAGAACGCAACATCCGGG CATATCCCGTTTACGCCTCGTGCGAAAAAGGTTCTAGAGCTTTCGCTCCGCGAGGCTCTTCAGCTTGGTCACAATTACAT TGGCACTGAGCATATACTCCTTGGGATTCTTCATGAGGGTGAGGGTATCGCTGCACAGGTACTGGTGAATATGGGGGCTG AACTGCCTGCAATTCAGCAGAGGGTTATGCACCTTTTAGAAGATGGAAGAGAACAAGAGCCCGTTTCGGTTGGCCCATCT GAGTCAGGAAAAATTTCAGGCAGTCAGATACTTGATCAATTCGGGCGACACCTCACGCGTGCCGCGAAAGAGGGCAAGTT GGACCCAGTTATTGGCCGTGAGAAGGAAATAGAGCGCGTGATGCAGGTGCTCTCGCGCAGAACGAAGAATAACCCAATCC TAATCGGTGAGCCCGGTGTTGGAAAAACTGCTGTCGTCGAGGCTTTGGCTCAAGCGATAGTCAATGGTGATGTTCCGGTC AATTTGCGCAACAAGCAAGTGTACTCGCTTGATTTGGGTTCTCTTATCGCTGGTAGCAGGTACAGGGGTGATTTTGAGGA ACGCCTCAAGAAGGTTACGAAGGAAATACGTTCACGAGGGGACATTATCGTTTTTATAGATGAGATCCATTCCCTTGTTG GGGCCGGGTCTGCTGAGGGTGCTATCGATGCAGCAACTATCCTGAAACCCCTTCTGGCCCGTGGTGAGCTTCAAACAATT GGCGCAACAACCCTTGATGAGTATCGCAAGAATATTGAAAAGGATTCTGCTCTGGAAAGGCGCTTCCAGCCCGTCAACGT GTCAGAGCCCAGCATACCAATGTGTATCCAGATACTGAAAGGGTTGCGTGATCGCTATGAGGCCCATCATAAGGTGAAAA TCACCGATGAGGCAATTTATGCTGCAGTTACCCTTTCGAGTCGTTATATAAATGATAGGTTTTTACCAGACAAAGCCATA GACTTGATTGATGAGGCCGGCGCCAGGCTGAGACTGTCTGTTTTGTCTAATCCGAGCCAACTGCGCGCTGTCGAGAAAAA AATTCTCGCTGTTGTTGCCAGGAAAGACAAGGCGGTTGAAAAACAGGATTTCGATAAAGTTGGCGAGCTAAAACGGAAAG AAAAGGCCCTAAGAGCTGAGTTACGGAAGATAAAGCGTGACTATGAGAATGGCAATATTGCAAGTGCCGGCACTGTAGAT GAGGGCTTGATCGCTGAAGTGCTTGCGTCAGCGACTGGGGTTCCCGTTTTTCGACTAACCGAAGACGAGTCCGTGCGTCT GATGATGATGGAAAGAAGTTTGCATCAGCGTGTGATTGGTCAGGACGAGGCGATTTCGTCTCTGTCAAGGGCGATGCGCC GAACGCGCGCTGGATTGAAGGATCCAAACCGACCTTCCGGATCGTTTATTTTTGCCGGCCCGACCGGTGTCGGAAAAACC GAGCTGGCCAAGGCTCTTGCCGAGTTTCTGTTTGATAATGAAGACGCCCTTGTAAGTCTTGACATGTCAGAGTACGGAGA GCGGCACACTGTATCCAGGCTTTTTGGAGCCCCGCCCGGATTTGTTGGTTTCGAAGAAGGCGGACAACTGACAGAGAAAA TACGCCGCAAGCCCTTTAGCGTTGTTTTATTTGATGAAATTGAAAAAGCCCATCCGGATGTTTTTAACTCGCTTTTGCAG ATTTTGGAAGAAGGTCGTCTGAGTGACGCCCAGGGCCGTATGGTTGATTTTAGAAATACGATAATTGTTATGACAACTAA CCTTGGCAGTCGCGATATAGCATCAGGCCCTGTCGGGTTTCAGTCGGGTGATGGTAGTTTTTTGGCCTATGAGGCTATGA AGGCCAAGGTTAATGAGGAACTGAGGCGCAGTTTAAAGCCGGAGTTTCTCAATCGTATTGATGAAGTTATAGTTTTCCCG CCCCTCAATAGAGACGAGCTTCTGCAAATACTGAAGATTTTTATCAAAAAGCTCGATGACCGTTTGCGCGATAGGACCAT GCGTCTTTCTGTGACAGATGCTGCCCTAGAACAGTTGGTGCAAATTGGCTACGAACCCACCATGGGAGCAAGGCCCTTGC GCCGAGCGGTTCAGCGCGAGGTTGAGGATAGGATTTCTGAAAAGATTCTGCTGGGCGAGATAAAGCCAAATCAAGAGATA GAAATGGACTTTGTGAATGATAATTTCACGATTGTATCAAGGGATATGGATTACCCCCTATCTCCTCTTGTGCCGTCAGT GACAACGGGTCTCGTTACTCCGGATCTTGCAAGTCACGTCTAG Protein sequence : MGEDMFERFTDKARRVIVLAQEEARTLSHNYIGTEHVLLGLISEGDGIAAQALESLDITLERAREGVAELIGRGQNATSG HIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGILHEGEGIAAQVLVNMGAELPAIQQRVMHLLEDGREQEPVSVGPS ESGKISGSQILDQFGRHLTRAAKEGKLDPVIGREKEIERVMQVLSRRTKNNPILIGEPGVGKTAVVEALAQAIVNGDVPV NLRNKQVYSLDLGSLIAGSRYRGDFEERLKKVTKEIRSRGDIIVFIDEIHSLVGAGSAEGAIDAATILKPLLARGELQTI GATTLDEYRKNIEKDSALERRFQPVNVSEPSIPMCIQILKGLRDRYEAHHKVKITDEAIYAAVTLSSRYINDRFLPDKAI DLIDEAGARLRLSVLSNPSQLRAVEKKILAVVARKDKAVEKQDFDKVGELKRKEKALRAELRKIKRDYENGNIASAGTVD EGLIAEVLASATGVPVFRLTEDESVRLMMMERSLHQRVIGQDEAISSLSRAMRRTRAGLKDPNRPSGSFIFAGPTGVGKT ELAKALAEFLFDNEDALVSLDMSEYGERHTVSRLFGAPPGFVGFEEGGQLTEKIRRKPFSVVLFDEIEKAHPDVFNSLLQ ILEEGRLSDAQGRMVDFRNTIIVMTTNLGSRDIASGPVGFQSGDGSFLAYEAMKAKVNEELRRSLKPEFLNRIDEVIVFP PLNRDELLQILKIFIKKLDDRLRDRTMRLSVTDAALEQLVQIGYEPTMGARPLRRAVQREVEDRISEKILLGEIKPNQEI EMDFVNDNFTIVSRDMDYPLSPLVPSVTTGLVTPDLASHV |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| clpC | YP_005163377.1 | ATP-dependent Clp protease ATP-binding subunit | Not tested | Not named | Protein | 0.0 | 63 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| TW075 | NP_789025.1 | Clp-family ATP-binding protease/regulator | VFG0079 | Protein | 0.0 | 55 |
| TW075 | NP_789025.1 | Clp-family ATP-binding protease/regulator | VFG0080 | Protein | 4e-150 | 49 |
| TW075 | NP_789025.1 | Clp-family ATP-binding protease/regulator | VFG2084 | Protein | 9e-95 | 42 |
