Gene Information

Name : guaA (blr3989)
Accession : NP_770629.1
Strain : Bradyrhizobium japonicum USDA 110
Genome accession: NC_004463
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 4425934 - 4427589 bp
Length : 1656 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
GTGGGCGTGCAAACCTGCGCGGTTGCGGGCCGGGGCGTGGTCGCGTATCTGCTTGCCATGACAGCAGCACAGAACGACCG
CTCCGCGTCGACGCCCTCCGTGGCCTCGGCGCATGACAAGATTCTCATCGTCGACTTCGGCAGCCAGGTGACGCAGCTGA
TCGCGCGTCGCGTGCGCGAGGACGGCGTCTATTGCGAGATCGTCCCGTTCAACAAGGCCGAAGAGGCCTTCAAGGAGATG
AAGCCGAAGGCGGTGATCCTCTCCGGCGGGCCGGAATCGGTGCACGAGGCCGGCTCTCCGCGCGCCCCGCAATTGATCTT
CGCCTCCGGCGTGCCCGTGATGGGCATCTGCTACGGCCAGATGACCATGGCGGCGCAGCTCGGCGGTGAGGTCGAGGGCG
GCCATCACCGCGAATTCGGCCGCGCCGATGTCGAGGTGAAGGCGCAGAGCAAGCTGTTCGAGGACGTCTGGTCATCAGGC
AGCAAGAACCAGGTCTGGATGAGCCATGGCGACCGCATCACCAAGATGCCGCCGGGCTTCTCGGTGGCCGGCACCTCGCC
GAACGCGCCCTTCGCGATCATCCAGGACGAGAAGCGCAAATATTACGGCCTGATGTTCCACCCCGAAGTGGTGCACACGC
CCGACGGCGCCAAGCTGATCCGCAACTTCGTGCGCAAGATCGCCGGCCTCACCGGCGACTGGACCATGCGCGCCTTCCGC
GAGGAGGAGATTGCCAAGATCCGCGCCCAGGTCGGCAAGGGCAAGGTGATCTGCGGCCTCTCCGGCGGCGTCGATTCGGC
CGTCGCGGCCGTGCTGATCCACGAAGCCATCGGCGACCAGCTGACGTGTGTGTTCGTCGATCACGGCTTGATGCGCCTCA
ACGAGGCCGAGCAGGTGGTTGACCTGTTCCGCCACCACTACAACATCCCGCTCGTGCACGTGGATGCGTCGAAGCAGTTT
TTGGGCGAACTCGAAGGCGTCACCGACCCCGAGACCAAGCGCAAGACCATCGGCCGCCTCTTCATCGAGGTGTTCGAGGC
CGAGGCCAAGAAGATCGGCGGCGCCGACTTCCTCGCGCAAGGCACGCTCTATCCTGATGTGATCGAGAGCGTCTCGTTCA
CCGGCGGACCTTCAGTCACCATCAAGTCGCACCACAATGTCGGCGGTCTCCCTGAACGCATGAACATGAAGCTCGTCGAG
CCCCTGCGCGAGCTGTTCAAGGACGAGGTGCGCAAGTTAGGGCGCGAGCTCGGCCTGCCCGAAATCTTCGTCGGCCGCCA
CCCGTTCCCGGGCCCGGGCCTCGCCATCCGCTGCCCCGGCGACATCACAAGCGACAAGCTCGACATCCTGCGCAAGGCCG
ATGCCGTCTACATCGACCAGATCCGCAAGCACGGCCTCTACGACGACATCTGGCAGGCTTTTGCGGTGCTGCTCCCCGTG
AAGACGGTGGGCGTCATGGGCGACGGCCGCACCTACGACTACGTCGTGGGTCTGCGCGCCGTCACCTCCACCGACGGCAT
GACCGCGGACTTCTACCAGTTCGACATGAAGTTCTTAGGCGAGACCGCCACGCGCATCATCAACGAGGTGAAGGGCGTGA
ACCGGGTGGTGTACGACGTGACCAGCAAGCCGCCCGGGACGATTGAGTGGGAGTAG

Protein sequence :
MGVQTCAVAGRGVVAYLLAMTAAQNDRSASTPSVASAHDKILIVDFGSQVTQLIARRVREDGVYCEIVPFNKAEEAFKEM
KPKAVILSGGPESVHEAGSPRAPQLIFASGVPVMGICYGQMTMAAQLGGEVEGGHHREFGRADVEVKAQSKLFEDVWSSG
SKNQVWMSHGDRITKMPPGFSVAGTSPNAPFAIIQDEKRKYYGLMFHPEVVHTPDGAKLIRNFVRKIAGLTGDWTMRAFR
EEEIAKIRAQVGKGKVICGLSGGVDSAVAAVLIHEAIGDQLTCVFVDHGLMRLNEAEQVVDLFRHHYNIPLVHVDASKQF
LGELEGVTDPETKRKTIGRLFIEVFEAEAKKIGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMKLVE
PLRELFKDEVRKLGRELGLPEIFVGRHPFPGPGLAIRCPGDITSDKLDILRKADAVYIDQIRKHGLYDDIWQAFAVLLPV
KTVGVMGDGRTYDYVVGLRAVTSTDGMTADFYQFDMKFLGETATRIINEVKGVNRVVYDVTSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-134 54
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-134 54
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-134 54
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-119 50