Gene Information

Name : lysS (SE2266)
Accession : NP_765821.1
Strain : Staphylococcus epidermidis ATCC 12228
Genome accession: NC_004461
Putative virulence/resistance : Virulence
Product : lysyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG1190
EC number : 6.1.1.6
Position : 2338924 - 2340411 bp
Length : 1488 bp
Strand : -
Note : class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA

DNA sequence :
ATGTCAGAAGAAATGAACGACCAAATGCAAGTTCGTCGTCAAAAATTACAAGAATTAATTGATTTAGGGATTGATCCTTT
TGGTCATCGATTCAATCGCTCATCTACTTCAAGTGAGTTAAAAGAACAGTGGGACCAATTCTCTAAGGAAGAATTGCATG
AAAAAGAAGACGAAAGCCACGTGTCAATTGCAGGTCGTCTTATGACTAAACGTGGTAAAGGTAAAGCGGGATTTGCACAT
ATTCAAGACTTGAAAGGTCAGATTCAAATTTATGTAAGAAAAGATCAAGTTGGAGATGATCAATTTAACATTTGGAAAAT
GGCTGACTTAGGTGACATCATAGGTGTTGAAGGTGTCATGTTTAAAACTAATACGGGCGAGATTTCTGTCAAAGCTAAGT
CATTTACTTTACTATCCAAATCATTACGACCTTTACCTGATAAGTTCCATGGTTTACAAGATATAGAACAAAGATATCGA
CAACGTTATTTAGATTTAATTACAAATGAAGATAGTACGCAAACGTTTATTAATCGTAGTAAAATAATTCAAGAAATGAG
AAACTATTTAAATAAACAAGGATTCTTGGAAGTAGAAACACCAATGATGCACCAAATTGCTGGAGGTGCTGCTGCACGTC
CGTTTGTTACGCATCATAACGCATTAGATGCTACTCTTTATATGCGTATAGCTATAGAACTACATTTGAAACGGTTAATT
GTCGGAGGTCTTGAAAAAGTCTACGAGATAGGCAGAGTTTTTCGTAATGAAGGTGTATCTACAAGACATAACCCTGAATT
TACAATGATTGAATTGTATGAAGCTTATGCTGATTATCATGATATAATGGATTTAACTGAAAATATGGTCAGACACATTG
CTCAAGAAGTGTTTGGATCAGCTAAAGTACAATATAATGATGAAGAAATTGACTTAGAATCTTCATGGAAACGACTTCAC
ATTGTTGATGCTGTTAAAGAAGTTACCGGTGTAGATTTTTATAATGTTAATTCTGATGAAGAAGCTATTAGATTAGCAAA
AGAACATGATATTGAAATTACTGAAAATATGAAATATGGCCATATATTAAATGAATTTTTTGAACAGAAAGTTGAAGAAA
CACTTATTCAACCAACGTTTATTTATGGTCACCCTATTGAAATTTCACCGTTAGCAAAGAAAAATCCAAACGATGAAAGA
TTTACTGATCGTTTTGAATTATTTATTGTAGGAAGAGAGCATGCAAATGCCTTCACGGAATTAAACGATCCGATTGATCA
ACGCCAACGTTTTGAAGCGCAGCTTGTTGAAAAAGAACAAGGAAATGATGAAGCTCATGATATGGATGAGGATTACATCG
AAGCATTAGAGTATGGAATGCCTCCAACTGGTGGTCTAGGTATCGGTATCGACAGATTAGTAATGCTATTAACTGATTCT
CCGTCAATTAGAGACGTATTACTATTCCCATACATGAGACAAAAATAG

Protein sequence :
MSEEMNDQMQVRRQKLQELIDLGIDPFGHRFNRSSTSSELKEQWDQFSKEELHEKEDESHVSIAGRLMTKRGKGKAGFAH
IQDLKGQIQIYVRKDQVGDDQFNIWKMADLGDIIGVEGVMFKTNTGEISVKAKSFTLLSKSLRPLPDKFHGLQDIEQRYR
QRYLDLITNEDSTQTFINRSKIIQEMRNYLNKQGFLEVETPMMHQIAGGAAARPFVTHHNALDATLYMRIAIELHLKRLI
VGGLEKVYEIGRVFRNEGVSTRHNPEFTMIELYEAYADYHDIMDLTENMVRHIAQEVFGSAKVQYNDEEIDLESSWKRLH
IVDAVKEVTGVDFYNVNSDEEAIRLAKEHDIEITENMKYGHILNEFFEQKVEETLIQPTFIYGHPIEISPLAKKNPNDER
FTDRFELFIVGREHANAFTELNDPIDQRQRFEAQLVEKEQGNDEAHDMDEDYIEALEYGMPPTGGLGIGIDRLVMLLTDS
PSIRDVLLFPYMRQK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed CAD66193.1 putative lysil-tRNA synthetase LysU Not tested PAI III 536 Protein 9e-120 50

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
lysS NP_765821.1 lysyl-tRNA synthetase VFG1668 Protein 5e-120 50