Gene Information

Name : thyA (SE1120)
Accession : NP_764675.1
Strain : Staphylococcus epidermidis ATCC 12228
Genome accession: NC_004461
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 1129461 - 1130417 bp
Length : 957 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGTATAATCCATTCGACGAAGCTTATCATGGCTTATGCGAAGAGATATTAGAAATAGGGAATAGACGCGATGATCGCAC
ACATACCGGGACAATTTCCAAATTTGGGCATCAATTGCGTTTCGATTTAACCAAAGGGTTTCCTTTACTTACAACCAAAA
AGGTTTCTTTTAAATTAGTAGCAACTGAATTATTATGGTTTATTAAAGGAGATACAAACATTCAATACCTACTTAAATAT
AATAACAATATATGGAATGAATGGGCATTTGAAAATTATGTTCAGTCTGATGATTATCATGGACCAGACATGACAGATTT
TGGACATCGTTCCCAGCAAGACCCTGAATTTAACGAGCAGTATAAAGAAGAAATGAAAAAATTTAAAGAACGTATTCTAA
ACGATGATGCATTTGCTAAAAAATATGGCAACTTAGGGAATGTTTATGGTAAACAATGGAGAGATTGGGAAGATAAAAAT
GGGAATCATTACGATCAATTAAAATCAGTTATACAACAAATTAAAACCAATCCAAACTCTCGACGTCACATTGTTTCAGC
ATGGAATCCTACTGAAATCGATTCAATGGCATTACCACCTTGCCACACAATGTTTCAATTTTACGTACAAGAGGGTAAAT
TAAATTGTCAATTATATCAAAGAAGTGCTGATATATTTTTAGGTGTTCCTTTCAATATTGCAAGTTATGCTTTACTGACA
CATCTTGTTGCAAAAGAATGTGGACTTGAGGTGGGTGAATTCATTCATACATTTGGAGATGCACATATTTATTCCAATCA
TATGGATGCAATACATACACAATTATCAAGAGATAGTTATCTACCACCTCAATTAAAAATTAATACAGATAAATCAATTT
TTGATATTAATTATGAAGATTTAGAATTGATAAATTATGAATCACACCCTGCTATTAAAGCACCTATTGCGGTATAA

Protein sequence :
MYNPFDEAYHGLCEEILEIGNRRDDRTHTGTISKFGHQLRFDLTKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKY
NNNIWNEWAFENYVQSDDYHGPDMTDFGHRSQQDPEFNEQYKEEMKKFKERILNDDAFAKKYGNLGNVYGKQWRDWEDKN
GNHYDQLKSVIQQIKTNPNSRRHIVSAWNPTEIDSMALPPCHTMFQFYVQEGKLNCQLYQRSADIFLGVPFNIASYALLT
HLVAKECGLEVGEFIHTFGDAHIYSNHMDAIHTQLSRDSYLPPQLKINTDKSIFDINYEDLELINYESHPAIKAPIAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 4e-149 100