Gene Information

Name : thyA (MYPE6870)
Accession : NP_758075.1
Strain : Mycoplasma penetrans HF-2
Genome accession: NC_004432
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 883159 - 884028 bp
Length : 870 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAAAGAATATAAAGACTTATTAAAACTGGTTTTAGATAATGGGATAATGCAAGAGAACAGAACTGATACTGATGCTAT
TGCATATTTTGGAACACAATCTAGATATGATCTAACTAAAGGTTTTCCATTATTAACAACTAAGAAAATGGCTTATAAAG
CAATTTTCCATGAATTATTATGATTTTTAAAAGGTGAAACTAATATTAAATACCTTGTGGATAATAATGTAAAAATCTGA
AATGAATGACCTTATGAAAACTATAAAAAATCTCCATATTTCAAAAATGAATCTATTGATGAATTCATTTTAAAAATTAA
AGAAGATGATTCATTTGCTAAACAATTTGGTGAACTTGGACCAGTATATGGAAGACAATGAAGAAATTTTAATGGGGTAG
ATCAAATTACTAATCTAATAGAAGAGATCAAGAAAAATAAGTATTCTAGAAGATTAATTGTAAGTGTTTGAAATCCTAGT
GAAATTAAAAATATGTTATTACCACCTTGTCATTGTTTATTTCAATTTTTTGTTAATTCAAAAAATGAATTATCTTGTCA
GTTATATCAAAGAAGTGCAGATCTATTTTTAGGAGTTCCTTTTAATATTGCTTCATATAGTTTATTAACTTATATGATTG
CTCAAGTTACAAATACTACTGCAAAAGAATTTGTTCACACTATTGGAGTAGCTCATATTTATAACAATCATATTGATCAA
GTTAAAGAACAACTAACTAGAGAACCATTGCAATTACCAACATTAGTATTAAATAAAAATATTAAAAATATCTTTGATTT
TAAAATAGAAGATATTGAAATTAAAGATTATAATTCTCATCCAGCTATTAAAGGGAAGGTAGCAGTATAA

Protein sequence :
MKEYKDLLKLVLDNGIMQENRTDTDAIAYFGTQSRYDLTKGFPLLTTKKMAYKAIFHELLWFLKGETNIKYLVDNNVKIW
NEWPYENYKKSPYFKNESIDEFILKIKEDDSFAKQFGELGPVYGRQWRNFNGVDQITNLIEEIKKNKYSRRLIVSVWNPS
EIKNMLLPPCHCLFQFFVNSKNELSCQLYQRSADLFLGVPFNIASYSLLTYMIAQVTNTTAKEFVHTIGVAHIYNNHIDQ
VKEQLTREPLQLPTLVLNKNIKNIFDFKIEDIEIKDYNSHPAIKGKVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 2e-67 49
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 2e-59 48