Gene Information

Name : guaA (MYPE1220)
Accession : NP_757510.1
Strain : Mycoplasma penetrans HF-2
Genome accession: NC_004432
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 148181 - 149716 bp
Length : 1536 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGGATAAAATTTTAATTTTAGATTTTGGTGGTCAATACACTCAATTGATTGCTAGAAGAATAAGAGATTTGAATGTATA
TAGTGAAATAGTAGATTATGATATTTCAATCGAAGAAATAATTAAGAAAAATCCTAAGGGAATTATTTTATCTGGTGGAT
ATGATAGTGTTTATGGAGACAGAAGTATAAAACCAAATAAAGGGATTTGAGATTTAAATATTCCAATATTAGGAATTTGT
TATGGTTTTCAAGTAATGATGCAAGAAAATGGTGGACAAGTTGAAAATGATAAAGATTCAGAAGAATATGGTTCTACTGA
TATTAGACTTACTACAAATGAGTTATTTGAAAATATTGAATTAGACAACAATTGTTGAATGAGTCACTCTGATAGTGTTA
TCTTTTTACCTAAAGGGTTTAAAGTAATCGCTTCAACTAATAAATGTTTAGTAGCATCTGCATGTAATAGAGAGAAAAAA
TTTTATGGGGTTCAATTCCATCCAGAAGTTACTCAAACTACATTTGGTAATCAATTGCTTCAAAACTTTGTTTATTCAAT
TTGTGATGTAGCAGGTGATTGAGAACCTAAAAACATTAAGTTAGAAAAAATAGAAGAAATCAAATCTATTGTTAAAGATG
ATTATGTTTTATGTGCAATTAGTGGTGGAGTAGATTCATTAGTTGCTGCAGTATTAACAGCTCAAGCTATTGGAGATAAA
TTATATTGTGTTTTTGTAGACCATGGTTTACTTAGAAAAAATGAATCTCAAGAGGTTTGTGCATTACTAAAAAAACTAAT
TGGTAAAAATATCTTTTTAGTAGATCAAAAACAATTATTTTTATCTAAGTTAAAAGGAGTTGTAGATCCTGAACAAAAAA
GAAAAATTATTGGTAAGACTTTTATAGAAGTATTTGAAAAGGTAGCTAATAAAATTAATGTTCCTTTTAAATATTTATTA
CAAGGTACAATTTATCCAGATATTGTAGAAAGTGGTAGTAAATTTTCTAAAACCATTAAGTCACACCACAATGTTGGTGG
TTTACCTGAAAGATTACAATTTGAATTATTAGAACCTTTAAAATACTTATTTAAAGATGAAGTAAGAAAGTTGGGACTAA
GTCTTGATATACCTTATCAAAATGTTTATCGTCAACCATTCCCAGGTCCTGGGCTAGCTGTAAGAGTATTGGGTGAAATT
ACTGAAGATAAATTAGAAATAGTAAGAGAAGCAGATTTTTTATTTAGATCTTATATAGATCAACTTTATAAAAACTCTGA
ACACAAACCATGACAATATTTTACAGTTTTAACTAACTCAAAATCTGTTGGTGTAGTTGGTGATAACAGATCTTATGGCT
ATACATTAGCTTTAAGAGCAGTAGATAGTATGGATGCTATGAGTGCTAAGTGATATAAAATTCCTTTAGAACATTTAGAA
AAAATTAGTTCTATTATTTGTAATAAAGTTAAAAATATTAGCAGAGTAGTTTATGACATAACTAATAAACCACCTGGAAC
AATTGAATGAGAATAA

Protein sequence :
MDKILILDFGGQYTQLIARRIRDLNVYSEIVDYDISIEEIIKKNPKGIILSGGYDSVYGDRSIKPNKGIWDLNIPILGIC
YGFQVMMQENGGQVENDKDSEEYGSTDIRLTTNELFENIELDNNCWMSHSDSVIFLPKGFKVIASTNKCLVASACNREKK
FYGVQFHPEVTQTTFGNQLLQNFVYSICDVAGDWEPKNIKLEKIEEIKSIVKDDYVLCAISGGVDSLVAAVLTAQAIGDK
LYCVFVDHGLLRKNESQEVCALLKKLIGKNIFLVDQKQLFLSKLKGVVDPEQKRKIIGKTFIEVFEKVANKINVPFKYLL
QGTIYPDIVESGSKFSKTIKSHHNVGGLPERLQFELLEPLKYLFKDEVRKLGLSLDIPYQNVYRQPFPGPGLAVRVLGEI
TEDKLEIVREADFLFRSYIDQLYKNSEHKPWQYFTVLTNSKSVGVVGDNRSYGYTLALRAVDSMDAMSAKWYKIPLEHLE
KISSIICNKVKNISRVVYDITNKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-126 56
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-126 56
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-126 55
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-112 46