Gene Information

Name : c5371 (c5371)
Accession : NP_757219.1
Strain : Escherichia coli CFT073
Genome accession: NC_004431
Putative virulence/resistance : Unknown
Product : prophage P4 integrase
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0582
EC number : -
Position : 5115549 - 5116700 bp
Length : 1152 bp
Strand : +
Note : Int(P4); Escherichia coli K-12 ortholog: b4271; Escherichia coli O157:H7 ortholog: z5890

DNA sequence : 
GTGAGTATACTTATAAGTATATTTGCCGATTCGATATTGCTTGTATACTCACGAGATACCAATGGAAGGAAGACCATTAT
GGCCCTAACGGATACTAAAGTTCGCTCTGCGAAACCTGAGGAGAAAGAGTATTCACTTGTTGACGGCGACGGCATGTCCT
TACTTGTAAAACCTGGCGGTTCAAAGTATTGGCGATTTCGTTTCCGTTTTGGCGGTAAACAACATTTGATGGCGTTCGGC
GTTTACCCGGATGTTTCGCTGGCAGATGCCAGGAAGAAAAGGGAAGAGGCCAGAAAGCTGGTAACTGCTGGTATCGATCC
TCGAGAGCATAAGCGGGCTGTGAAAGAAGAGCAGGCGAAAGAGATTATTACTTTCGAGAAGGTTGCCAGAGAGTGGCTCG
TAACCAACCAAAAATGGTCGGAAGATCATGCTAATCGTGTAAAAAAGAGCCTGGAGGACAATATCTTCCCAACAATTGGT
GCTCGCAATATTGCTGAACTGGGCACCCGCGATCTGTTAATTCCCATTAAAGCCGTGGAGAAATCCGGACGTCTTGAAGT
GGCTTCCCGCCTTCAACAGCGCACCACGGCCATCATGCGTTATGCAGTGCAAAGCGGGTTAATTGATTACAATCCGGCGC
AAGAGATGGCGGGGGCGGTTGCTTCCAGTAATCGACAGCATCGTCCGGCGCTGGAGTTAAAGCGTATCCCGGAATTACTC
CAGAAAATCGATGACTACACCGGCAGGCCGCTAACCCGCTGGGCAACCGAACTTACTCTGCTTATTTTTATTCGATCCAG
TGAGCTGCGTTTTGCTCGCTGGTCAGAAATCGATTTTGAAACGTCAATGTGGACCATCCCGCCTGAGCGAGAGCCTATTC
CCGGCGTGAAACATTCTCAGCGAGGATCAAAGATGCGTACACCGCATCTGGTGCCATTTTCAAAGCAGGCGCTGGCGATC
CTGAAGCAGATAAAACAGTTCTGTGGCGAACATGAGCTGATTTTTATTGGCGATCACGATCCGCGTAAGCCCATGAGCGA
AAACACGGTAAACAGTGCACTACGGGTGATGGGTTATGACACTAAGGTTGAAGTTTGCGGCCACGGCTTCCGTACAATGG
CCTGTAGTTCGTTAATTGAGTCAGGGCTATGA

Protein sequence : 
MSILISIFADSILLVYSRDTNGRKTIMALTDTKVRSAKPEEKEYSLVDGDGMSLLVKPGGSKYWRFRFRFGGKQHLMAFG
VYPDVSLADARKKREEARKLVTAGIDPREHKRAVKEEQAKEIITFEKVAREWLVTNQKWSEDHANRVKKSLEDNIFPTIG
ARNIAELGTRDLLIPIKAVEKSGRLEVASRLQQRTTAIMRYAVQSGLIDYNPAQEMAGAVASSNRQHRPALELKRIPELL
QKIDDYTGRPLTRWATELTLLIFIRSSELRFARWSEIDFETSMWTIPPEREPIPGVKHSQRGSKMRTPHLVPFSKQALAI
LKQIKQFCGEHELIFIGDHDPRKPMSENTVNSALRVMGYDTKVEVCGHGFRTMACSSLIESGL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
intB CAD42017.1 bacteriophage P4 integrase Not tested PAI II 536 Protein 4e-132 81
ECO111_3718 YP_003236059.1 putative integrase Not tested LEE Protein 6e-115 64
ORF_1 AAZ04412.1 phage integrase Not tested PAI I APEC-O1 Protein 1e-116 64
APECO1_3534 YP_854214.1 P4-like integrase Not tested PAI I APEC-O1 Protein 2e-116 64
S4822 NP_838459.1 P4-type integrase Not tested SHI-1 Protein 7e-117 64
SF2964 NP_708738.1 P4-type integrase Not tested SHI-1 Protein 7e-117 64
int ADD91747.1 P4 integrase Not tested PAI-I AL862 Protein 8e-117 64
int AAT48697.1 CP4-like integrase Not tested PAI I 4787 Protein 3e-116 64
int AAL51003.1 CP4-like integrase Not tested LEE Protein 2e-116 64
intP4 CAE85151.1 CP4 integrase protein Not tested PAI V 536 Protein 8e-117 64
int AAK16198.1 Int Not tested PAI-I AL862 Protein 8e-117 64
int AAK00456.1 Int Not tested SHI-1 Protein 1e-107 64
c5216 NP_757064.1 prophage P4 integrase Not tested PAI II CFT073 Protein 3e-116 63
int-phe AAL57571.1 CP4-like integrase Not tested LEE Protein 6e-116 63
int AAL51028.1 CP4-like integrase Not tested LEE Protein 6e-116 63
c3556 NP_755431.1 prophage P4 integrase Not tested PAI I CFT073 Protein 1e-115 63
int-phe AAL60261.1 Int-phe Not tested LEE Protein 6e-116 63
ECO103_3550 YP_003223418.1 integrase Not tested LEE Protein 9e-116 63
ECO26_5300 YP_003232178.1 integrase Not tested LEE Protein 9e-116 63
ECUMN_3322 YP_002414004.1 integrase Not tested Not named Protein 3e-114 63
int CAC81896.1 integrase Not tested LEE II Protein 1e-106 63
Z4313 NP_289539.1 pathogenicity island integrase Not tested OI-122 Protein 4e-115 62
SESS1296_03598 AFO66301.1 bacteriophage integrase Not tested SESS LEE Protein 7e-110 61
SESS1635_03816 AFO66367.1 bacteriophage integrase Not tested SESS LEE Protein 7e-110 61
APECO1_1051 YP_853069.1 phage integrase Not tested PAI IV APEC-O1 Protein 7e-67 55
STY4821 NP_458899.1 integrase Not tested SPI-10 Protein 5e-94 55
intB AAD37509.1 P4-like integrase Not tested PAI IV 536 Protein 1e-72 55
y2393 NP_669700.1 prophage integrase Not tested HPI Protein 1e-88 54
int2 NP_993013.1 integrase Not tested HPI Protein 1e-88 54
int CAA08754.1 integrase Not tested HPI Protein 1e-88 54
int CAA21384.1 - Not tested HPI Protein 1e-88 54
int CAB59974.1 integrase Not tested HPI Protein 3e-89 54
int YP_002346908.1 integrase Not tested HPI Protein 1e-88 54
int NP_458759.1 bacteriophage integrase Not tested SPI-7 Protein 9e-91 53
int NP_807963.1 bacteriophage integrase Not tested SPI-7 Protein 9e-91 53
unnamed AAD17660.1 unknown Not tested HPI Protein 4e-85 52
unnamed ABR13507.1 phage integrase Not tested PAGI-6 Protein 2e-83 51
int AAC31482.1 CP4-like integrase Not tested LEE Protein 2e-72 44
int ACU09430.1 integrase Not tested LEE Protein 2e-72 44
intL NP_290239.1 integrase for prophage 933L and the LEE pathogenicity island Not tested LEE Protein 2e-72 44
ECs4534 NP_312561.1 integrase Not tested LEE Protein 2e-72 44
int CAC39282.1 integrase Not tested LPA Protein 2e-74 44
int AAD44730.1 Int Not tested SHI-2 Protein 2e-74 44
aec33 AAW51716.1 Int Not tested AGI-3 Protein 2e-74 44
ESA_03025 YP_001439090.1 hypothetical protein Not tested Not named Protein 1e-65 43
int AAD54663.1 Sai integrase Not tested SHI-2 Protein 1e-72 43
S4835 NP_839238.1 integrase Not tested SHI-2 Protein 1e-72 43
SF3698 NP_709437.1 integrase Not tested SHI-2 Protein 1e-72 43
unnamed AFX83955.1 integrase Not tested SE-PAI Protein 6e-65 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
c5371 NP_757219.1 prophage P4 integrase VFG1536 Protein 2e-132 81
c5371 NP_757219.1 prophage P4 integrase VFG0626 Protein 3e-117 64
c5371 NP_757219.1 prophage P4 integrase VFG1693 Protein 6e-116 63
c5371 NP_757219.1 prophage P4 integrase VFG0783 Protein 1e-72 44
c5371 NP_757219.1 prophage P4 integrase VFG0598 Protein 6e-73 43