Gene Information

Name : alr (c5028)
Accession : NP_756880.1
Strain : Escherichia coli CFT073
Genome accession: NC_004431
Putative virulence/resistance : Unknown
Product : alanine racemase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG0787
EC number : 5.1.1.1
Position : 4804186 - 4805265 bp
Length : 1080 bp
Strand : +
Note : converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer

DNA sequence :
ATGCAAGCGGCAACTGTTTTGATTAACCGCCGCGCTCTGCGACACAACCTGCAACGTCTGCGTGAACTGGCCCCCGCCAG
TAAACTGGTGGCGGTGGTGAAAGCGAACGCCTACGGTCACGGTCTGATTGAGACCGCGCGAACGCTCCCCGATGCTGACG
CCTTTGGCGTTGCCCGTCTCGAAGAAGCCCTACGGCTGCGGGCGGGGGGTATCACGCGACCTATTTTGTTACTGGAAGGT
TTTTTTGAAGCAGACGATTTGCCGACGATCTCCGCTGAACATCTGCATACCGCAGTCCACAATGAAGAGCAGCTTGTCGC
CCTCGAAAACGCTGAACTTAAAGAGCCTGTCACCGTCTGGATGAAGCTCGATACCGGAATGCACCGTTTGGGCGTATTGC
CGGAACAGGCCGAGGCGTTTTATCAGCGTCTGAGCCAGTGTAAAAATGTCCGCCAGCCGGTGAACATTGTTAGTCACTTC
GCCCGTGCCGATGAACCGCAAAGCGGCGCGACTGAAAAGCAGCTCGATATCTTCAACACCTTTTGTGAAGGTAAACCGGG
GCAACGCTCAATTGCGGCATCAGGCGGCATTTTGTTATGGCCGCAGTCGCATTTTGACTGGGCGCGTCCGGGGATCATTC
TTTACGGTGTCTCGCCGCTGGAAGATGGCACGACAGGGGCTGATTTTGGCTGTCAGCCAGTCATGTCTTTAACCTCCAGC
CTGATTGCCGTGCGTGAGCATAAAGCCGGAGAGCCTGTCGGTTATGGTGGAACCTGGGTAAGCGAACGTGATACTCGTCT
TGGCGTAGTCGCGATGGGCTATGGCGATGGTTATCCGCGCGCCGCGCCGTCCGGTACGCCAGTGCTGGTGAACGGTCGCG
AAGTGCCGATTGTCGGGCGAGTCGCGATGGATATGATCTGCGTAGACTTAGGTCCACAGGCGCAGGACAAAGCCGGGGAC
CCGGTCATTTTATGGGGCGAAGGTTTGCCCGTAGAACGTATCGCTGAAATGACGAAAGTAAGCGCTTACGAACTTATTAC
GCGCCTGACTTCAAGAGTCGCGATGAAATACGTGGATTAA

Protein sequence :
MQAATVLINRRALRHNLQRLRELAPASKLVAVVKANAYGHGLIETARTLPDADAFGVARLEEALRLRAGGITRPILLLEG
FFEADDLPTISAEHLHTAVHNEEQLVALENAELKEPVTVWMKLDTGMHRLGVLPEQAEAFYQRLSQCKNVRQPVNIVSHF
ARADEPQSGATEKQLDIFNTFCEGKPGQRSIAASGGILLWPQSHFDWARPGIILYGVSPLEDGTTGADFGCQPVMSLTSS
LIAVREHKAGEPVGYGGTWVSERDTRLGVVAMGYGDGYPRAAPSGTPVLVNGREVPIVGRVAMDMICVDLGPQAQDKAGD
PVILWGEGLPVERIAEMTKVSAYELITRLTSRVAMKYVD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
dadX AAC61705.1 alanine racemase Not tested PAI I CFT073 Protein 6e-59 44