Gene Information

Name : c3976 (c3976)
Accession : NP_755842.2
Strain : Escherichia coli CFT073
Genome accession: NC_004431
Putative virulence/resistance : Virulence
Product : N-acetylmannosamine kinase
Function : -
COG functional category : K : Transcription
COG ID : COG1940
EC number : 2.7.1.60
Position : 3794637 - 3795512 bp
Length : 876 bp
Strand : -
Note : catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein

DNA sequence : 
ATGACCACACTGGCGATTGATATCGGCGGTACTAAACTTGCCGCCGCGCTGATTGGCGCTGACGGGCAGATCCGCGATCG
CCGAGAACTTCCTACGCCTGCCAGCCAGACTCCGCAGGCGCTGCGTGATGCCTTATCCGCATTAGTCTCTCCGTTGCAAG
CACATGCGCAGCGGGTTGCCATCGCTTCAACCGGAATTATTCGCGACGGCAGCTTGCTGGCGCTGAATCCGCATAATCTC
GGTGGATTGTTACACTTTCCGTTAGTCAAAACGCTGGAGCAACTTACCAATTTGCCGACCATTGCCATTAATGATGCGCA
GGCCGCAGCATGGGCGGAGTATCAGGCGCTGGATGGCGATATAACCGATATGGTGTTTATCACTGTTTCCACCGGCGTTG
GCGGCGGTGTAGTGAGCGGCGGTAAACTGCGTACCGGCCCTGGCGGTCTGGCGGGGCATATCGGGCATACGCTTGCCGAT
CCGCATGGTCCAGTCTGCGGCTGTGGACGCACAGGTTGCGTGGAAGCGATTGCTTCTGGTCGCGGCATTGCAACGGCAGC
GCAGGGGGAGTTGGCTGGTGCGAATGCGAAAACTATTTTCACGCGCGCCGGGCAGGGTGATGAGCAGGCGCAGCAACTGA
TTCACCGCTCCGCACGTACGCTTGCAAGGCTGATCGCTGATATTAAAGCCACAACTGATTGCCAGTGCGTGGTGGTCGGT
GGCAGCGTTGGTCTGGCAGAAGGGTATCTGGCGCTGGTGGAAACGTATCTGGCGCAGGAGCCAGCGGCATTTCATGTTGA
TTTACTGGCGGCGCACTACCGCCACGATGCAGGTTTACTTGGGGCTGCGCTGTTGGCCCAGGGAGAAATATTATGA

Protein sequence : 
MTTLAIDIGGTKLAAALIGADGQIRDRRELPTPASQTPQALRDALSALVSPLQAHAQRVAIASTGIIRDGSLLALNPHNL
GGLLHFPLVKTLEQLTNLPTIAINDAQAAAWAEYQALDGDITDMVFITVSTGVGGGVVSGGKLRTGPGGLAGHIGHTLAD
PHGPVCGCGRTGCVEAIASGRGIATAAQGELAGANAKTIFTRAGQGDEQAQQLIHRSARTLARLIADIKATTDCQCVVVG
GSVGLAEGYLALVETYLAQEPAAFHVDLLAAHYRHDAGLLGAALLAQGEIL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
nanK YP_002414055.1 N-acetylmannosamine kinase Not tested Not named Protein 2e-44 54
VC1782 NP_231417.1 N-acetylmannosamine kinase Not tested VPI-2 Protein 2e-32 41
VC0395_A1379 YP_001217322.1 N-acetylmannosamine kinase Not tested VPI-2 Protein 2e-32 41
VPI2_0030 ACA01847.1 ROK family protein Not tested VPI-2 Protein 2e-32 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
c3976 NP_755842.2 N-acetylmannosamine kinase VFG1115 Protein 8e-33 41