Gene Information

Name : c3689 (c3689)
Accession : NP_755564.1
Strain : Escherichia coli CFT073
Genome accession: NC_004431
Putative virulence/resistance : Virulence
Product : 3-deoxy-manno-octulosonate cytidylyltransferase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG1212
EC number : 2.7.7.38
Position : 3516005 - 3516745 bp
Length : 741 bp
Strand : +
Note : CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS

DNA sequence :
ATGAGCAAAGCTGTTATTGTCATCCCGGCTCGTTATGGCTCATCGCGCCTGCCGGGTAAGCCACTGCTCGATATTGTTGG
TAAACCGATGATCCAGCATGTTTACGAGCGTGCGTTACAGGTGGTGGGCGTTGCGGAAGTTTGGGTGGCAACAGACGATC
AGCGTGTTGAAAAGGCCGTGCAGGCATTTGGCGGGAAATCCATCATGACGCGCAACGATCATGAATCCGGCACCGATCGG
CTGGTCGAGGTGATGCATAAAGTCGAGGCAGATATCAACATTAACCTGCAGGGCGACGAACCAATGATTCGCCCACGGGA
TGTAGGAACGCTGTTACAAGGAATGCGTGATGACCCCGCGTTGCCAGTGGCAACGCTATGCCACGCGATTTCTGCCGAAG
AAGCGACCGAGCCAAGCACGGTAAAAGTGGTGGTAAATACCCGCCAGGATGCGCTTTATTTTAGCCGTTCGCCGATTCCC
TATCCGCGTAATGCTGAAAAAGCGCGCTACCTGAAACACGTTGGTATTTACGCTTATCGTCGCGATGTGCTGCAAAACTA
CAGCCAGTTACCGGAGTCCATGCCAGAGCAGGCAGAATCACTGGAGCAGCTACGGTTAATGAACGCGGGGATCAACATTC
GCACGTTTGAGATTGCCGCAACCGGTCCGGGCGTCGACACCCCAGCATGCCTGGAAAAAGTGCGCGCCCTGAGGGCACAG
GAACTGGCTGAAAACGCATGA

Protein sequence :
MSKAVIVIPARYGSSRLPGKPLLDIVGKPMIQHVYERALQVVGVAEVWVATDDQRVEKAVQAFGGKSIMTRNDHESGTDR
LVEVMHKVEADININLQGDEPMIRPRDVGTLLQGMRDDPALPVATLCHAISAEEATEPSTVKVVVNTRQDALYFSRSPIP
YPRNAEKARYLKHVGIYAYRRDVLQNYSQLPESMPEQAESLEQLRLMNAGINIRTFEIAATGPGVDTPACLEKVRALRAQ
ELAENA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
kpsU YP_854332.1 3-deoxy-manno-octulosonate cytidylyltransferase Not tested PAI I APEC-O1 Protein 1e-111 97
kpsU AAZ04469.1 CMP-KDO synthetase Virulence PAI I APEC-O1 Protein 1e-111 97
kpsU CAE85213.1 KpsU protein Virulence PAI V 536 Protein 2e-110 96