Gene Information

Name : hlyD (c3574)
Accession : NP_755449.1
Strain : Escherichia coli CFT073
Genome accession: NC_004431
Putative virulence/resistance : Virulence
Product : hemolysin D
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG1566
EC number : -
Position : 3424183 - 3425619 bp
Length : 1437 bp
Strand : +
Note : Residues 1 to 478 of 478 are 98.95 pct identical to residues 1 to 478 of 478 from SwissProt.40 : >sp|P09986|HLY4_ECOLI Hemolysin secretion protein D, chromosomal

DNA sequence :
ATGAAAACATGGTTAATGGGGTTCAGCGAGTTCCTGTTGCGCTATAAACTTGTCTGGAGTGAAACATGGAAAATCCGGAA
GCAATTAGATACTCCGGTACGTGAAAAGGACGAAAATGAATTCTTACCCGCTCATCTGGAATTAATTGAAACGCCGGTAT
CCAGACGGCCGCGTCTGGTTGCTTATTTTATTATGGGGTTTCTGGTTATTGCTGTCATTTTATCTGTTTTAGGTCAGGTG
GAAATTGTTGCCACTGCAAATGGGAAATTAACACTAAGTGGGCGCAGCAAAGAAATTAAACCTATTGAAAACTCAATAGT
TAAAGAAATTATCGTAAAAGAAGGAGAGTCAGTCCGGAAAGGGGATGTGTTATTAAAGCTTACAGCACTGGGAGCTGAAG
CTGATACGTTAAAAACACAGTCATCACTGTTACAGACCAGGCTGGAACAAACTCGGTATCAAATTCTGAGCAGGTCAATT
GAATTAAATAAACTACCTGAACTGAAGCTTCCTGATGAGCCTTATTTTCAGAATGTATCTGAAGAGGAAGTACTGCGTTT
AACTTCTTTGATAAAAGAACAGTTTTCCACATGGCAAAATCAGAAGTATCAAAAAGAACTGAATCTGGATAAGAAAAGAG
CAGAGCGATTAACAATACTTGCCCGTATAAACCGTTATGAAAATTTATCGAGAGTTGAAAAAAGCCGTCTGGATGATTTC
AGGAGTTTATTGCATAAACAGGCAATTGCAAAACATGCTGTACTTGAGCAGGAGAATAAATATGTCGAGGCAGCAAATGA
ATTACGGGTTTATAAATCGCAACTGGAGCAAATTGAGAGTGAGATATTGTCTGCAAAAGAAGAATATCAGCTTGTCACGC
AGCTTTTTAAAAATGAAATTTTAGACAAGCTAAGACAAACAACAGACAACATTGAGTTATTAACTCTGGAGTTAGAGAAA
AATGAAGAGCGTCAACAGGCTTCAGTAATCAGGGCCCCTGTTTCGGGAAAAGTTCAGCAACTGAAGGTTCATACTGAAGG
TGGGGTTGTTACAACAGCGGAAACACTGATGGTCATCGTTCCGGAAGATGACACGCTGGAGGTTACTGCTCTGGTACAAA
ATAAAGATATTGGTTTTATTAACGTCGGGCAGAATGCCATCATTAAAGTGGAGGCCTTTCCTTACACCCGATATGGTTAT
CTGGTGGGTAAGGTGAAAAATATAAATTTAGATGCAATAGAAGACCAGAAACTGGGACTCGTTTTTAATGTCATTGTTTC
TGTTGAAGAGAATGATTTGTCAACCGGGAATAAGCACATTCCATTAAGCTCGGGTATGGCTGTCACTGCAGAAATAAAGA
CTGGAATGCGAAGCGTAATCAGCTATCTTCTTAGTCCTCTGGAAGAGTCTGTAACAGAAAGTTTACATGAGCGTTAA

Protein sequence :
MKTWLMGFSEFLLRYKLVWSETWKIRKQLDTPVREKDENEFLPAHLELIETPVSRRPRLVAYFIMGFLVIAVILSVLGQV
EIVATANGKLTLSGRSKEIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQTRLEQTRYQILSRSI
ELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTILARINRYENLSRVEKSRLDDF
RSLLHKQAIAKHAVLEQENKYVEAANELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEILDKLRQTTDNIELLTLELEK
NEERQQASVIRAPVSGKVQQLKVHTEGGVVTTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGY
LVGKVKNINLDAIEDQKLGLVFNVIVSVEENDLSTGNKHIPLSSGMAVTAEIKTGMRSVISYLLSPLEESVTESLHER

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hlyD AAC61717.1 chromosomal hemolysin D Virulence PAI I CFT073 Protein 0.0 100
hlyD NP_755449.1 hemolysin D Virulence PAI I CFT073 Protein 0.0 100
hlyD CAD42037.1 HlyD protein Virulence PAI II 536 Protein 0.0 99
hlyD CAD33761.1 Hemolysin D Virulence PAI I 536 Protein 0.0 99

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
hlyD NP_755449.1 hemolysin D VFG0908 Protein 0.0 100
hlyD NP_755449.1 hemolysin D VFG1556 Protein 0.0 99
hlyD NP_755449.1 hemolysin D VFG1502 Protein 0.0 99
hlyD NP_755449.1 hemolysin D VFG0843 Protein 3e-120 57