Gene Information

Name : topB (c2166)
Accession : NP_754060.1
Strain : Escherichia coli CFT073
Genome accession: NC_004431
Putative virulence/resistance : Unknown
Product : DNA topoisomerase III
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0550
EC number : 5.99.1.2
Position : 2002243 - 2004246 bp
Length : 2004 bp
Strand : -
Note : decatenates replicating daughter chromosomes

DNA sequence :
TTGGCGAACTGGTGCCAGCGCGCGGCGGTCGTGCCATGGTTGAGATCCGTTAATTCAATGCGGTTGTTTATTGCCGAAAA
ACCGAGTCTGGCGCGCGCCATTGCTGATGTCCTGCCTAAACCGCACCGGAAAGGCGATGGCTTTATCGAGTGCGGTAATG
GTCAGGTGGTGACCTGGTGTATCGGTCACCTGCTTGAGCAGGCGCAGCCAGACGCCTACGACAGCCGCTATGCGCGCTGG
AATCTTGCGGATTTGCCAATTGTCCCGGAAAAGTGGCAATTACAGCCCCGACCCTCCGTGACTAAACAACTTAATGTCAT
CAAACACTTCCTGCATGAAGCCAGCGAAATCGTTCACGCCGGAGACCCGGATCGCGAAGGGCAACTGCTGGTGGATGAAG
TGCTGGACTACCTGCAACTAGCACCGGAAAAGCGCCAGCAGGTACAGCGTTGTTTGATAAACGACCTGAACCCGCAGGCG
GTTGAGCGGGCGATCGATCGTCTTCGCTCCAATAGCGAGTTTGTACCGCTGTGCGTTTCTGCACTGGCGCGGGCGCGGGC
TGACTGGCTGTACGGCATTAATATGACCCGTGCGTATACCATTCTCGGCCGCAATGCCGGTTATCAGGGCGTGCTTTCCG
TGGGACGCGTGCAGACGCCCGTACTCGGACTGGTGGTGCGCCGCGACGAAGAGATTGAAAACTTCGTGGCGAAAGACTTC
TTTGAAGTCAAAGCACATATCGTGACACCTGCAGATGAGCGGTTTACCGCTATCTGGCAACCGAGCGAAGCGTGTGAACC
GTACCAGGATGAAGAAGGGCGCTTGTTACATCGTCCACTGGCGGAGCATGTGGTTAACCGCATTAGTGGTCAACCAGCTA
TTGTCACCAGCTATAACGATAAACGGGAATCAGAATCCGCGCCGCTGCCTTTTTCGCTTTCGGCGTTGCAGATTGAAGCG
GCTAAACGTTTTGGTCTGAGCGCGCAGAACGTGCTTGATATCTGCCAGAAGCTGTACGAAACGCACAAGCTAATCACTTA
TCCGCGTTCCGATTGCCGCTATTTGCCAGAAGAACATTTTGCCGGACGCCACGCGGTGATGAATGCTATCAGCGTTCATG
CACCGGATCTGTTGCCGCAGCCAGTGGTAGATCCAGATATACGCAACCGCTGTTGGGATGACAAAAAGGTCGATGCGCAC
CACGCCATCATTCCGACCGCACGGAGTTCTGCGATCAACCTGACGGAGAACGAAGCGAAGGTCTATAACCTGATTGCCCG
TCAGTATTTGATGCAGTTCTGCCCGGATGCGGTGTTCCGCAAGTGTGTTATCGAACTGGACATTGCCAAAGGCAAATTTG
TCGCTAAAGCCCGTTTTCTTGCTGAAGCAGGCTGGCGCACGCTGTTAGGCAGCAAAGAGCGCGATGAAGAAAACGACGGC
ACGCCGCTGCCTGTGGTGGCGAAAGGCGATGAATTGTTGTGCGAAAAAGGTGAAGTGGTAGAGCGGCAAACCCAGCCGCC
ACGCCATTTTACCGATGCAACACTGCTTTCGGCGATGACCGGGATCGCACGCTTTGTGCAGGACAAAGATCTGAAAAAGA
TCCTTCGTGCGACCGATGGTCTGGGGACAGAAGCGACTCGCGCCGGGATTATTGAACTGCTGTTCAAGCGAGGCTTCCTG
ACCAAAAAAGGGCGCTATATCCACTCCACCGACGCCGGAAAAGCGCTATTCCATTCGCTGCCAGAAATGGCGACGCGACC
GGACATGACCGCGCACTGGGAATCGGTGCTGACGCAAATCAGCGAAAAGCAGTGTCGCTATCAGGACTTTATGCAGCCGC
TGGTGGGGACATTGTACCAGTTGATTGATCAGGCTCGTAGCACTCCGGTCAGACGGTTTAAAGGAATTGTGGTACCAAGG
AACGGAGACGAGAAAAATAAAGACGTGAAAAAAAGGGTCAAAAAAACTGCGCAGAAAAAGGATGCTACAGTTAAGCGTGA
CTGA

Protein sequence :
MANWCQRAAVVPWLRSVNSMRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW
NLADLPIVPEKWQLQPRPSVTKQLNVIKHFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQA
VERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDF
FEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA
AKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAH
HAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG
TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFL
TKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQARSTPVRRFKGIVVPR
NGDEKNKDVKKRVKKTAQKKDATVKRD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
topB1 YP_005176228.1 DNA topoisomerase III Not tested ICEPmu1 Protein 1e-109 41