Gene Information

Name : c1273 (c1273)
Accession : NP_753187.1
Strain : Escherichia coli CFT073
Genome accession: NC_004431
Putative virulence/resistance : Virulence
Product : antigen 43
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG3468
EC number : -
Position : 1225454 - 1228729 bp
Length : 3276 bp
Strand : +
Note : AG43; Sap; Escherichia coli K-12 ortholog: b2000; Escherichia coli O157:H7 ortholog: z1651

DNA sequence :
ATGCAGACACACAGACATGAGATTCAGGGAACAACAGAGCCACACGTCAGAAACTTCCATCAGCCGGATCTGCGGCACTG
TAACCCTTCACCTGCAGGTATCCACATTTGTGGATACCGGCTTTTTATTCACCCTCACTCTGATAAGGAAATGCTGATGA
AACGACATCTGAATACCAGCTACAGGCTGGTATGGAATCACATTACAGGCGCTTTCGTGGTTGCCTCCGAACTGGCCCGT
GCACGGGGGAAACGCGCCGGTGTGGCGGTTGCACTGTCTCTTGCCGCTGCCACGTCACTCCCGGCGCTGGCTGCTGACTC
TGTTGTACCGGCAGGAGAAACCGTGAACGGTGGAACGCTGATAAATCACGACCGCCAGTTTGTCTCAGGTACGGCTGATG
GAATGACTGTCAGCACCGGACTGGAGCTGGGGGCGGACTCTGATAACAACACCGGCGGTCAGCAGATAGCCCGGGGTGGA
ACAGCCAGAAACACCAGAGTCACCGCAAACGGTCTACAGGATGTCATGGCAGGTGGCAGTACCTCGGATACGGTTATCAG
TACCGGGGGAGGGCAGAATTTGCGTGGGAAGGCTTCCGGTACTGTCCTTAACGGCGGTGATCAATGGATACATGCAGGCG
GCAGGGCATCCGGAACGGTGATTAACCAGGATGGTTACCAGACCATTAAACATGGCGGACTGGTAACCGGAACCATCGTC
AACACCGGTGCAGAAGGTGGTCCGGATTCTGAAAATGTGTCCACCGGTCAGATGGTCGGGGGGATTGCTGAATCCACCAC
CATAAACAAAAATGGCCGGCAGGTTATCTGGTCTTCGGGGATAGCCCGGGACACTCTCATTTACACAGGAGGTGACCAGA
CGGTACACGGAGAGGCACATAACACCCGACTGGAGGGAGGGAACCAGTATGTGCACAAGTATGGACTTGCACTGAACACG
GTAATTAACGAGGGGGGCTGGCAGGTTGTTAAGGCCGGTGGTACTGCCGGTAACACCACCATAAATCAGAACGGCGAGCT
GAGGGTTCATGCCGGCGGTGAAGCGTCTGATGTCACCCAGAACACGGGAGGTGCACTGGTTACCAGCACTGCTGCAACTG
TCACCGGTACAAACCGCCTGGGAGCATTCTCTGTTGTGGAGGGTAAAGCTGATAATGTCGTACTGGAAAATGGCGGACGT
CTGGATGTGCTGAGCGGACACACAGCCACCAGAACCCTTGTGGATGATGGCGGAACGCTGGATGTCCGCAACGGTGGTAC
CGCCACTGCCGTATCCATGGGAAATGGCGGGGTACTGCTGGCCGATTCCGGGGCCGCTGTCAGTGGTACCCGGAGCGACG
GAACGGCATTCCGTATCGGGGGCGGTCAGGCGGATGCCCTGATGCTGGAAAAAGGCAGTTCATTCACGCTGAACGCCGGT
GATACGGCCACGGATACCACGGTAAATGGCGGACTGTTCACTGCCAGAGGGGGCTCGCTGGCGGGCACCACCACGCTGAA
TAACGGTGCCACGTTTACCCTTGCCGGGAAGACGGTGAACAACGATACCCTGACCATCCGTGAAGGTGATGCACTCCTGC
AGGGAGGCGCTCTCACCGGTAACGGCAGGGTGGAAAAATCAGGAAGTGGCACACTCACTGTCAGCAACACCACACTCACC
CAGAAAGCCGTCAACCTGAATGAAGGCACGCTGACGCTGAACGACAGTACCGTCACCACGGATATCATCGCTCATCGCGG
CACGGCCCTGAAGCTGACCGGCAGCACAGTGCTGAACGGTGCCATTGACCCCACGAATGTCACCCTGACATCCGGTGCCA
CCTGGAATATCCCCGATAACGCCACGGTTCAGTCGGTGGTGGATGACCTCAGCCATGCCGGACAGATTCATTTCACCTCC
GCCCGCACAGGGAAGTTCGTTCCGACAACTCTGCAGGTGAAAAACCTGAACGGGCAGAATGGCACCATCAGCCTGCGTGT
ACGCCCGGATATGGCGCAGAACAATGCTGACAGACTGGTCATTGACGGTGGCAGAGCAACCGGAAAAACCATCCTGAATC
TGGTGAACGCCGGCAACAGTGGTACGGGTCTGGCGACCACCGGTAAGGGTATTCAGGTGGTTGAGGCCATTAACGGTGCC
ACCACGGAGGAAGGGGCTTTTGTCCAGGGGAATATGCTGCAGGCCGGGGCCTTTAACTACACCCTCAACCGGGACAGTGA
TGAGAGCTGGTATCTGCGCAGTGAAGAACGTTATCGTGCTGAAGTCCCCCTGTACGCCTCCATGCTGACACAGGCAATGG
ACTATGACCGGATTCTGGCAGGCTCCCGCAGCCATCAGACCGGTGTAAACGGTGAAAATAACAGCGTCCGTCTCAGCATT
CAGGGCGGCCATCTCGGTCACGATAACAACGGCGGTATTGCCCGTGGGGCCACGCCGGAAAGCAGCGGCAGCTATGGCTT
CGTCCGTCTGGAGGGTGACCTGCTCAGAACAGAGGTCGCCGGTATGTCACTGACGACAGGAGTGTATGGTGCTGCAGGCC
ATTCTTCCGTTGATGTTAAGGATGATGACGGCTCCCGCGCCGGCACGGTCCGGGATGATGCCGGCAGCCTGGGCGGATAT
ATGAACCTGACACACACCTCCTCCGGCCTGTGGGCTGACATTGTGGCACAGGGAACCCGCCACAGCATGAAAGCGTCATC
GGACAATAACGACTTCCGCGCACGGGGCCGGGGCTGGCTGGGCTCACTGGAAACCGGTCTGCCCTTCAGTATCACTGACA
ACCTGATGCTGGAGCCACGGCTGCAGTACACCTGGCAGGGGCTTTCGCTGGATGACGGTAAGGACAACGCCGGTTATGTG
AAGTTCGGGCATGGCAGTGCACAGCATGTGCGTGCCGGTTTCCGTCTGGGCAGCCACAACGATATGACCTTTGGTGAAGG
CACCTCATCCCGTGCCCCCCTGCGTGACAGTGCAAAACACAGTGTGCGTGAACTGCCGGTGAACTGGTGGGTACAGCCTT
CCGTTATCCGCACCTTCAGCTCCCGGGGTGATATGCGTGTGGGGACCTCCACCGCAGGCAGCGGGATGACGTTCTCTCCC
TCACAGAATGGCACTTCACTGGATCTGCAGGCCGGACTGGAAGCCCGTGTCCGGGAAAATATCACCCTGGGCGTTCAGGC
CGGTTATGCCCACAGCATCAACGGCAGCAGCGCTGAAGGTTATAACAGTCAGGCCACACTGAATGTGACCTTCTGA

Protein sequence :
MQTHRHEIQGTTEPHVRNFHQPDLRHCNPSPAGIHICGYRLFIHPHSDKEMLMKRHLNTSYRLVWNHITGAFVVASELAR
ARGKRAGVAVALSLAAATSLPALAADSVVPAGETVNGGTLINHDRQFVSGTADGMTVSTGLELGADSDNNTGGQQIARGG
TARNTRVTANGLQDVMAGGSTSDTVISTGGGQNLRGKASGTVLNGGDQWIHAGGRASGTVINQDGYQTIKHGGLVTGTIV
NTGAEGGPDSENVSTGQMVGGIAESTTINKNGRQVIWSSGIARDTLIYTGGDQTVHGEAHNTRLEGGNQYVHKYGLALNT
VINEGGWQVVKAGGTAGNTTINQNGELRVHAGGEASDVTQNTGGALVTSTAATVTGTNRLGAFSVVEGKADNVVLENGGR
LDVLSGHTATRTLVDDGGTLDVRNGGTATAVSMGNGGVLLADSGAAVSGTRSDGTAFRIGGGQADALMLEKGSSFTLNAG
DTATDTTVNGGLFTARGGSLAGTTTLNNGATFTLAGKTVNNDTLTIREGDALLQGGALTGNGRVEKSGSGTLTVSNTTLT
QKAVNLNEGTLTLNDSTVTTDIIAHRGTALKLTGSTVLNGAIDPTNVTLTSGATWNIPDNATVQSVVDDLSHAGQIHFTS
ARTGKFVPTTLQVKNLNGQNGTISLRVRPDMAQNNADRLVIDGGRATGKTILNLVNAGNSGTGLATTGKGIQVVEAINGA
TTEEGAFVQGNMLQAGAFNYTLNRDSDESWYLRSEERYRAEVPLYASMLTQAMDYDRILAGSRSHQTGVNGENNSVRLSI
QGGHLGHDNNGGIARGATPESSGSYGFVRLEGDLLRTEVAGMSLTTGVYGAAGHSSVDVKDDDGSRAGTVRDDAGSLGGY
MNLTHTSSGLWADIVAQGTRHSMKASSDNNDFRARGRGWLGSLETGLPFSITDNLMLEPRLQYTWQGLSLDDGKDNAGYV
KFGHGSAQHVRAGFRLGSHNDMTFGEGTSSRAPLRDSAKHSVRELPVNWWVQPSVIRTFSSRGDMRVGTSTAGSGMTFSP
SQNGTSLDLQAGLEARVRENITLGVQAGYAHSINGSSAEGYNSQATLNVTF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed CAD66200.1 hypothetical protein Virulence PAI III 536 Protein 0.0 92
SF2991 NP_708765.1 outer membrane fluffing protein Not tested SHI-1 Protein 0.0 90
sap AAK00474.1 Sap Not tested SHI-1 Protein 0.0 90
aidA ADD91708.1 AidA Not tested PAI-I AL862 Protein 0.0 86
flu CAI43838.1 antigen 43 Not tested LEE Protein 0.0 86
Z1651 NP_287154.1 adhesin Not tested TAI Protein 0.0 58
Z1211 NP_286746.1 adhesin Not tested TAI Protein 0.0 58
unnamed AAL08472.1 putative autotransporter Not tested SRL Protein 0.0 57
unnamed CAE85197.1 antigen43 protein orthologue Not tested PAI V 536 Protein 0.0 57

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
c1273 NP_753187.1 antigen 43 VFG1675 Protein 0.0 92
c1273 NP_753187.1 antigen 43 VFG0655 Protein 0.0 90
c1273 NP_753187.1 antigen 43 VFG1063 Protein 0.0 57