Gene Information

Name : hsdM (SMU_891)
Accession : NP_721299.1
Strain : Streptococcus mutans UA159
Genome accession: NC_004350
Putative virulence/resistance : Unknown
Product : type I restriction-modification system DNA methylase
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG0286
EC number : -
Position : 845296 - 846900 bp
Length : 1605 bp
Strand : +
Note : Best Blastp Hit: pir||I41051 hsdM protein - Escherichia coli >gi|450688|emb|CAA53205.1| (X75452) hsdM gene of EcoprrI [Escherichia coli]

DNA sequence :
ATGTCGTTCAATAAGGAAAGTCAGCAAAGACAAGAATTGCATCAAAAAATATGGGCTATTGCTGACAATGTACGTGGTGC
TGTAGATGGTTGGGATTTTAAGCAATATATCTTAGGGATTCTTTTTTATCGTTTTATTTCTGAAAATATGTCTGATTATT
TTGATCGTGCTGAACATGAGGCCGGTGATCCAGACTTTCGTTATGCTGATCTCAGTGATGAAGAAGCTGAAGAAGATTTT
AAACCCGATACAGTAGAAGAAAAAGGCTTTTTTATTTTGCCTTCACAACTCTTTGAAAATATAGTCAAAACAGCCTCAAC
AAATGAAAATTTAAACACGGACTTAGCAAAGATTTTCAAGAAAATTGAAGAATCCGCAATTGGTAAAGATTCAGAACATG
CGATTAAGGGACTCTTTGATGATGTGGATACAACCTCAAATCGTTTGGGAGGTTCTGTTAAAGAAAAGAACAAACGATTA
TCAGATATTTTGACAGGAATAGCTGGGCTTGATTTTGGCACTTTTGAAGAAAATGATATTGATGCATTTGGTGATGCCTA
TGAGTATCTGATTTCTAACTATGCCTCTAATGCAGGAAAAAGTGGCGGAGAGTTTTTTACACCGCAAACTGTTTCGAAAC
TTCTTGCTCAACTTGTTATGGTTGGAAAAGAGCATATTAATAAAGTATATGATCCAACTTGTGGTTCGGGTTCACTATTA
CTTCAAATGAAGAAACAATTTGAAACCCATATTTTGGAAGAAGGTTTTTTTGGTCAAGAGATCAATATGACTAATTATAA
CTTAGCACGAATGAATATGTTTCTTCATAATATCAACTATAATAATTTTGATATTCGCCGTGGCGATACCTTGTTGAACC
CTCAGCATCTATACGAACGACCTTTTGATGCCATTGTTTCTAATCCTCCTTATTCTATCAAGTGGATTGGGGATGCTGAT
CCAACCTTAATTAATGATGAGCGCTTTGCACCAGCTGGTAAATTAGCTCCTAAATCAAAAGCTGATTTTGCCTTTATTAT
GCACAGTCTTAGCCATTTATCCAATAAAGGTCGTGCAGCAATTGTTTGCTTTCCTGGAATTTTTTATCGCGGGGGTGCTG
AGAAGACAATCCGTCAATACTTGATTGATAATAATTTTGTTGAAGCTGTTATTGCCTTGCCTGATAATCTTTTTTATGGA
ACAAGCATTGCAACCTATATTTTAGTTTTGGCAAAAAATAAACCTGAGGATAAAACACTTTTTATTGATGCTTCTTCAGA
TGAAAAATCTACGGTTTCTGGTAAGAATAAATTTTATGAGACAGTAACCAATGGCAAGATATTAAACCCGAAAAATATCG
AAGCTATTGTTGAATTATTTAAGAATAAAAAAGATGTCGATTATGAGGCTAAACTTGTCGATAATAATCTGATTGCTGAA
GAAAATGATTACAATTTATCTGTATCAACCTATGTCGAAAAGCGTGACACACGCGAAATTATCAATATTGATGAACTCAA
CAAAGAAATTGCTGAAACGGTTAAGAAGATTGATCATCTACGCAGTGAGATTGATAAAATTGTGGAGGAGCTGAGCCATG
ACTAA

Protein sequence :
MSFNKESQQRQELHQKIWAIADNVRGAVDGWDFKQYILGILFYRFISENMSDYFDRAEHEAGDPDFRYADLSDEEAEEDF
KPDTVEEKGFFILPSQLFENIVKTASTNENLNTDLAKIFKKIEESAIGKDSEHAIKGLFDDVDTTSNRLGGSVKEKNKRL
SDILTGIAGLDFGTFEENDIDAFGDAYEYLISNYASNAGKSGGEFFTPQTVSKLLAQLVMVGKEHINKVYDPTCGSGSLL
LQMKKQFETHILEEGFFGQEINMTNYNLARMNMFLHNINYNNFDIRRGDTLLNPQHLYERPFDAIVSNPPYSIKWIGDAD
PTLINDERFAPAGKLAPKSKADFAFIMHSLSHLSNKGRAAIVCFPGIFYRGGAEKTIRQYLIDNNFVEAVIALPDNLFYG
TSIATYILVLAKNKPEDKTLFIDASSDEKSTVSGKNKFYETVTNGKILNPKNIEAIVELFKNKKDVDYEAKLVDNNLIAE
ENDYNLSVSTYVEKRDTREIINIDELNKEIAETVKKIDHLRSEIDKIVEELSHD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hsdM1 YP_185366.1 type I restriction-modification system, M subunit Not tested vSa¥á Protein 2e-102 44
SAS0394 YP_042520.1 restriction enzyme modification protein Not tested vSa¥á Protein 8e-102 44
hsdM YP_001331432.1 type I restriction-modification system, methyltransferase subunit Not tested vSa¥á Protein 2e-102 44
hsdM NP_373642.1 type I site-specific deoxyribonuclease LldI subunit HsdM Not tested vSa¥á Protein 7e-102 44
hsdM YP_493119.1 type I restriction-modification system, M subunit Not tested vSa¥á Protein 2e-102 44
SAS1732 YP_043848.1 type I restriction enzyme modification protein Not tested vSa¥â Protein 5e-102 44
hsdM NP_646568.1 hypothetical protein Not tested vSa¥â Protein 5e-102 44
SAR1899 YP_041281.1 type I restriction modification system modification protein Not tested vSa¥â Protein 6e-101 44
SAV1808 NP_372332.1 type I restriction enzyme EcoR124II M protein Not tested vSa¥â Protein 5e-102 44
SAMSHR1132_03780 YP_005324900.1 putative type I restriction enzyme modification protein Not tested vSa¥á Protein 2e-101 44
SA1626 NP_374915.1 hypothetical protein Not tested vSa¥â Protein 5e-102 44
hsdM NP_370955.1 type I site-specific deoxyribonuclease LldI chain Not tested vSa¥á Protein 2e-101 44
ORF6 BAC22943.1 - Not tested etd PI Protein 7e-102 44
SAKOR_00415 YP_008490599.1 Type I restriction-modification system methylation subunit Not tested vSa¥á Protein 3e-102 44
hsdM NP_645209.1 type I site-specific deoxyribonuclease LldI chain hsdM Not tested vSa¥á Protein 9e-102 44
hsdM2 YP_186690.1 type I restriction-modification system, M subunit Not tested vSa¥â Protein 3e-102 44
SAR0433 YP_039884.1 type I restriction enzyme modification protein Not tested vSa¥á Protein 8e-102 44
hsdM YP_001332734.1 type I restriction-modification system, methyltransferase subunit Not tested vSa¥â Protein 2e-102 44
hsdM YP_494443.1 type I restriction-modification system, M subunit Not tested vSa¥â Protein 2e-102 44
SAKOR_01757 YP_008491945.1 Type I restriction-modification system methylation subunit Not tested vSa¥â Protein 1e-102 44
SSP0053 YP_300143.1 type I restriction-modification system methyltransferase subunit Not tested SCC15305cap Protein 7e-98 43
SAMSHR1132_16570 YP_005326167.1 restriction-modification system, M subunit Not tested vSa¥â Protein 6e-101 43