Gene Information

Name : pykF (SMU_1190)
Accession : NP_721573.1
Strain : Streptococcus mutans UA159
Genome accession: NC_004350
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : -
Position : 1130761 - 1132263 bp
Length : 1503 bp
Strand : -
Note : Best Blastp Hit: gb|AAF25804.1|AF172173_2 (AF172173) pyruvate kinase [Streptococcus thermophilus]

DNA sequence :
ATGAATAAACGCGTAAAAATTGTTGCAACTTTAGGTCCAGCGGTAGAAATCCGTGGTGGTAAAAAATTTGGTGAAGATGG
CTATTGGGGTGAAAAGCTTGATGTTGAAGCTTCAGCAGCAAAAATTGCTGAATTGATTACAGAAGGAGCCAATGTTTTTC
GTTTTAACTTTTCACATGGTGACCATGCTGAGCAAGGTGAACGTATGGCGACTGTACGTCGCGCGGAAGAATTGGCACGT
CAAAAGGTTGGATTCCTTCTTGATACTAAAGGACCTGAAATGCGTACAGAATTGTTTGCAGATGGTGTCAAAGAATATGA
ATATAAGACTGGTGATAAACTTCGTATAGCAACTAAACAAGGCATTGAATCAACTAAGGATGTCATTGCTTTAAATGTTG
CAGGCGGTCTTGATATTTATGATGATGTTGCTGTCGGTCAGACTATTCTTATTGATGATGGGAAACTTGGCCTTACAGTA
ACCGCTAAAGATATTACAACTCGCGAGTTTGAAGTAACCGTTGAAAATGATGGCATTATTGCTAAACAAAAAGGTGTCAA
TATTCCTAATACTAAAATTCCTTTCCCAGCACTTGCTGAGCGTGATAATGCAGATATTCGCTTTGGTTTGGAACAAGGTC
TTAACTTTATTGCTATTTCTTTTGTTCGTACTGCTAAGGATGTTAATGAAGTTCGTCAAATTTGTAAAGAAACAGGTAAC
GAGCACGTAAAACTTTTTGCTAAAATTGAAAATCAACAAGGTATTGATAACATTGATGAAATCATTGATGCAGCTGACGG
TATCATGATTGCTCGCGGTGACATGGGTATTGAAGTGCCGTTTGAAATGGTTCCAGTTTATCAAAAAATGATTATCACGA
AAGTTAATGCAGCAGGGAAGTCAGCTATCACAGCAACAAATATGCTTGAAACAATGACTGACAAACCACGTGCAACACGT
TCCGAAGTCTCTGATGTCTTTAATGCTGTCATTGATGGTACTGATGCAACAATGCTTTCTGGTGAATCAGCTAATGGTAA
GTATCCAGTTGAAGCTGTTCGTACCATGGCAACAATTGATAAGAATGCTCAAACACTTCTTAATGAATATGGCCGTTTGA
ATTCAGATAATTTGCCACGTACCAACAAGACTGAGGTTGTCGCTTCAGCTGTTAAAGATGCGACTAAATCAATGGATATT
AAATTGGTTGTTACAATTACAGAATCTGGTAACACAGCTCGTTTAATTTCAAAATACCGTCCGGATGCAGATATCTTAGC
TTTAACATTTGATGAAAAAGTCCAAAAATCATTGATGATTAACTGGGGAGTTATTCCAATCTTAACAGAAAAACCTGCAT
CTACTGATGATATGTTTGAAATTGCAGAAAAAGCAGCTCTTAAATCAGGTTTGGTAGAGTCTGGTGACAACATCGTTATT
GTTGCTGGTGTACCGGTTGGATCTGGTGGTACCAATACTATGCGTGTTCGTACCGTTCAATAA

Protein sequence :
MNKRVKIVATLGPAVEIRGGKKFGEDGYWGEKLDVEASAAKIAELITEGANVFRFNFSHGDHAEQGERMATVRRAEELAR
QKVGFLLDTKGPEMRTELFADGVKEYEYKTGDKLRIATKQGIESTKDVIALNVAGGLDIYDDVAVGQTILIDDGKLGLTV
TAKDITTREFEVTVENDGIIAKQKGVNIPNTKIPFPALAERDNADIRFGLEQGLNFIAISFVRTAKDVNEVRQICKETGN
EHVKLFAKIENQQGIDNIDEIIDAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKSAITATNMLETMTDKPRATR
SEVSDVFNAVIDGTDATMLSGESANGKYPVEAVRTMATIDKNAQTLLNEYGRLNSDNLPRTNKTEVVASAVKDATKSMDI
KLVVTITESGNTARLISKYRPDADILALTFDEKVQKSLMINWGVIPILTEKPASTDDMFEIAEKAALKSGLVESGDNIVI
VAGVPVGSGGTNTMRVRTVQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 1e-69 43
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 3e-70 43
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 3e-70 43
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 2e-70 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pykF NP_721573.1 pyruvate kinase VFG0479 Protein 1e-70 43