Gene Information

Name : blaA (SO_0837)
Accession : NP_716468.1
Strain : Shewanella oneidensis MR-1
Genome accession: NC_004347
Putative virulence/resistance : Resistance
Product : class D carbapenem-hydrolyzing beta-lactamase BlaA
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG2602
EC number : 3.5.2.6
Position : 854515 - 855312 bp
Length : 798 bp
Strand : +
Note : -

DNA sequence :
ATGCGTGTGTTAGCCTTATCGGCTGTATTAGTGGTGGCATCGATTGTTGGCATGCCGGCGATGGCAAACGAATGGCAGGA
AAAACCGAGTTGGAATACTCATTTTTCGGAACATAAAGCGCAGGGTGTGATAGTGCTTTGGAACGAGAACAAACAGCAAG
GATTTACCAATAATCTTAAGCGGGCAAACCAAGCATTTTTACCCGCATCGACCTTTAAAATCCCCAATAGCTTGATTGCC
TTGGATTTAGGTGTCGTGAAGGATGAGCATCAAGTCTTTAAATGGGATGGACAGACTCGGGATATCGCGGCGTGGAATCG
CGACCATGACTTAATCACTGCGATGAAATACTCGGTCGTGCCCGTGTATCAAGAGTTTGCGCGCCAAATTGGGCAGGCGC
GCATGAGTAAAATGTTGCACGCATTTGATTATGGCAATGAAGATATTTCGGGCAATCTAGACAGCTTTTGGCTCGATGGC
GGCATTCGGATTTCGGCAACGGAGCAAGTCGCATTTCTACGAAAGCTGTATCATAACAAGTTGCATGTATCAGAACGCAG
TCAGCGTATCGTCAAGCAAGCCATGCTTACCGAGGCTAATAGTGACTACATAATCCGCGCTAAAACCGGATACTCGACCA
GAATTGAGCCTCAGATCGGTTGGTGGGTCGGTTGGGTTGAACTCGATGATAATGTGTGGTTCTTCGCGATGAATATGGAT
ATGCCTACGGCTGATGGTTTAGGGCTACGTCAAGCCATCACTAAAGAAGTGCTTAAACAGGAAAAGATAATTCCATAG

Protein sequence :
MRVLALSAVLVVASIVGMPAMANEWQEKPSWNTHFSEHKAQGVIVLWNENKQQGFTNNLKRANQAFLPASTFKIPNSLIA
LDLGVVKDEHQVFKWDGQTRDIAAWNRDHDLITAMKYSVVPVYQEFARQIGQARMSKMLHAFDYGNEDISGNLDSFWLDG
GIRISATEQVAFLRKLYHNKLHVSERSQRIVKQAMLTEANSDYIIRAKTGYSTRIEPQIGWWVGWVELDDNVWFFAMNMD
MPTADGLGLRQAITKEVLKQEKIIP

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
bla OXA-10 CAJ77047.1 Oxacillinase Not tested AbaR1 Protein 3e-60 48
bla OXA-129 AFG30109.1 OXA-129 beta-lactamase Not tested PAGI-2 Protein 3e-56 47
blaOXA-129 AET25386.1 OXA-129 beta-lactamase Not tested PAGI-2(C) Protein 3e-56 47
blaOXA-2 YP_005176242.1 beta-lactamase OXA-2 protein Not tested ICEPmu1 Protein 5e-41 44
ACICU_00226 YP_001844885.1 Beta-lactamase class D Not tested AbaR20 Protein 8e-42 43
BJAB0715_00989 YP_008216137.1 Beta-lactamase class D Not tested AbaR27 Protein 1e-40 41
oxa23 AEO37447.1 class D beta-lactamase OXA-23 Not tested AbaR4 Protein 1e-40 41
oxa-23 AFV47968.1 class D beta-lactamase OXA-23 Not tested AbaR25 Protein 1e-40 41
oxa-23 AFV47996.1 class D beta-lactamase OXA-23 Not tested delta-AbaR25 Protein 1e-40 41
bla(Oxa-23) AFH57213.1 carbapenemase Not tested AbaR4b Protein 1e-40 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA AY500137.1.gene1.p01 Protein 1e-115 100
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA JN205800.1.gene6.p01 Protein 8e-112 94
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA HM015773.1.gene6.p01 Protein 1e-111 93
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA HQ700343.1.gene1.p01 Protein 5e-108 91
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA AY343493.1.gene1.p01 Protein 1e-72 59
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA X75562.1.gene1.p01 Protein 5e-57 48
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA Z22590.1.gene1.p01 Protein 9e-60 48
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA U59183.1.gene3.p01 Protein 5e-60 48
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA NC_010410.6002874.p0 Protein 2e-60 48
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA AF231133.1.gene3.p01 Protein 9e-59 48
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA AY445080.1.gene1.p01 Protein 2e-59 48
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA AJ854182.1.gene1.p01 Protein 5e-60 48
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA U37105.2.gene2.p01 Protein 2e-60 48
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA AM412777.1.gene1.p01 Protein 2e-59 48
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA AM932669.1.gene2.p01 Protein 2e-56 47
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA X58272.1.gene1.p01 Protein 2e-56 47
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA AF300985.1.gene1.p01 Protein 1e-39 45
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA AF350424.1.gene1.p01 Protein 2e-38 45
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA L07945.1.gene1.p01 Protein 8e-42 45
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA AF315351.1.gene2.p01 Protein 1e-41 45
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA AY139598.1.gene3.p01 Protein 1e-41 44
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA AF317511.1.gene5.p01 Protein 8e-41 44
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA JF800667.1.gene2.p01 Protein 2e-40 44
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA AF371964.1.gene1.p1 Protein 4e-41 44
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA DQ522237.1.gene5.p01 Protein 1e-41 44
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA Y10693.2.gene1.p2 Protein 1e-41 44
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA GQ202693.1.gene2.p01 Protein 3e-41 44
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA EF552405.1.gene1.p01 Protein 5e-41 44
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA M95287.gene.p01 Protein 2e-41 44
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA JF795487.1.gene1.p01 Protein 2e-40 44
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA U63835.1.gene1.p01 Protein 5e-41 44
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA AF024602.1.gene3.p01 Protein 4e-42 43
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA AY289608.1.gene2.p01 Protein 1e-40 43
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA EU086834.1.gene1.p01 Protein 6e-35 41
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA JF273470.1.gene1.p01 Protein 2e-35 41
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA EU086830.1.gene1.p01 Protein 4e-35 41
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA FJ194494.1.gene1.p01 Protein 3e-40 41
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA AY288523.1.gene1.p01 Protein 2e-40 41
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA HM488990.1.gene1.p1 Protein 5e-41 41
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA AY795964.gene.p01 Protein 6e-41 41
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA HM488992.1.gene1.p1 Protein 2e-40 41
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA HM488988.1.gene1.p1 Protein 5e-41 41
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA HM488991.1.gene1.p1 Protein 9e-41 41
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA HM488989.1.gene1.p1 Protein 6e-41 41
blaA NP_716468.1 class D carbapenem-hydrolyzing beta-lactamase BlaA NC_011586.7044972.p0 Protein 6e-41 41