Gene Information

Name : thyA (WGLp320)
Accession : NP_871323.1
Strain : Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis
Genome accession: NC_004344
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 376418 - 377212 bp
Length : 795 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAAAGAATATTTAGATTTGTTAAATTTGATTTTAAAAAATGGATATCCAAAAATAGATAGAACAAAAACTGGAACTTT
ATCTATGTTTGGATATCAAATAAGAATTAATTTAAATGAAGGATTTCCGTTATTAACAACAAAATATTGTCATTTTAAAT
CAATAGTATATGAATTGCTTTGGTTTTTAAGAGGGGACACAAATATATCATTTTTAAAAAAAAATAATATTTCTATTTGG
AATAAATGGGCAGATAAAAATGGAAACCTAGGTCCAATATATGGAAAACAATGGCGTGCTTGGGAAGATAAAAAAAATAA
CACTATTGATCAAATTGAAATAGCTTTAAATAAATTAAAAAAAGAACCTTCTTCTAGAAGAATACTAGTTTCTTCATGGA
ATGTTGGAGAGTTAGATTTGATGTCCATACCTCCATGTCACGTTTTATTTCAACTATATGTAATAAATAATAAATTGTCT
TGTCAAGTATATCAAAGATCTTGCGATATTTTTTTAGGATTACCTTTTAACATAGGAAGTTATGCTTTGTTGACTCATAT
TTTTGCTAATCAATGCGATTTGCTAGTTGAAGATTTAATATGGACAGGAGGAGACATTCATTTATACAAAAATCATTTAA
ATCAAGCAAAATTACAATTAACAAGATCCCCTTTACCATTACCAAAAATTTTTATTAAAAAAAAACCTAAAAATTTATTT
AATTATGCATTTAATGATTTTTTACTTATTGATTATAATCATCATCCAAAAATAAAAGCTCCAATATCAATTTAA

Protein sequence :
MKEYLDLLNLILKNGYPKIDRTKTGTLSMFGYQIRINLNEGFPLLTTKYCHFKSIVYELLWFLRGDTNISFLKKNNISIW
NKWADKNGNLGPIYGKQWRAWEDKKNNTIDQIEIALNKLKKEPSSRRILVSSWNVGELDLMSIPPCHVLFQLYVINNKLS
CQVYQRSCDIFLGLPFNIGSYALLTHIFANQCDLLVEDLIWTGGDIHLYKNHLNQAKLQLTRSPLPLPKIFIKKKPKNLF
NYAFNDFLLIDYNHHPKIKAPISI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 2e-68 56