Gene Information

Name : guaA (BL0960)
Accession : NP_696136.1
Strain : Bifidobacterium longum NCC2705
Genome accession: NC_004307
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 770364 - 771971 bp
Length : 1608 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
GTGTTCAGCCCACGTAAAATTCCAATGAACGTTAGGGGAATATCAATGGCAAACGGTCCTGTGCTTGTCGTCGACTTCGG
CGCCCAGTACGCCCAGCTCATCGCCCGCCGCGTGCGCGAAGCAGGCGTGTACTCCGAGCTGGTCCCTCATTCCATGCCGG
TCGACGAGATCCTGGCCAAGGATCCGAAGGCGATTATTCTGTCTGGCGGCCCGGCCTCCGTGTTCGAGCCCGGCGCGCCG
ACCATAGACACCAAGGTATTCGAATCCGGTGTTCCGGTGCTTGGTATCTGCTACGGCTTCCAGGTCATGGCCTATGAGCT
CGGCGGCAAGGTGGATAAGGCCGCGCTCGGCGAATACGGCAAGACCTCAGCCACCATCGACGACGCCGCCGGCATCCTCG
CCGACTCCCCCGCCGAGCAGACCACGTGGATGAGCCACGGTGTGGCGGTCGAACAGGCCCCGGCCGGCTTCGAAGTGCTG
GCCCACACCGAAGGCGCGCCCGTGGCCGCCATGGCGGACGAATCCCGCAAGCTCTATGGTGTGCAGTGGCACCCGGAAGT
CAAGCACTCCCCGCTTGGCCAGAAGCTTATCGAAAACTTCCTGCACCGTTGCGCCGCGCTGCCCAACGACTGGGATGCCT
CCTCGATTATCGAGGATCAAGTCAAGAAGATCCGCGAGCAGGTCGGCGACGCCGAGGTGATCTGCGGCCTGTCCGGCGGC
GTTGATTCCGCCGTGGCCGCCGCTCTGGTACACAAGGCCATCGGCGACCAGCTCACCTGCGTGTTCGTGGACCACGGCCT
GCTGCGCAAGGGCGAAGTCGAGCAGGTCAAGCACGACTTCGTCGCCGCGACCGGCATCCGCCTCATCACCGTCGACGCCG
CCGACGACTTCCTCGACGCCCTCGCAGGCGTCTCCGAGCCGGAGCGCAAGCGCAAGATCATCGGCGAGAAGTTCATCCGC
ACGTTCGAGAAGGCCCAGCGCCAAGTGCTTGAAGAGGCCGGCGCGCGCGGCAAGGAAGTCAAGTTCCTCGTGCAGGGCAC
CCTCTACCCCGACGTCGTCGAATCCGGCGGCGGCGACGGCGCGGCCAACATCAAGTCCCACCACAACGTCGGTGGCCTGC
CTAAGGACATCAAGTTCCAGCTCATCGAACCGCTGCGCACCCTGTTCAAGGACGAGGTGCGCGCCATCGGAACCGAACTC
GGACTGCCGGATGAGATCGTCTGGCGCCAGCCCTTCCCCGGCCCGGGTCTGGGCATCCGTATCATCGGCGAGATCACCAA
GGAGCGTCTCGACCTGTTGCGCGAGGCCGACGCCATCGCCCGCGAGGAGCTCTCCAAGGCCGGCCTCGACCGTGACATCT
GGCAGTGCCCGGTCGTGCTGCTCGCCGACGTTCACTCGGTTGGCGTCCAAGGCGACGAGCGCACCTACGGCTCCCCCATC
GTGCTGCGTCCGGTGAGCTCGGAGGACGCCATGACCGCCGACTGGTCTCGCGTGCCCTACGACGTGCTCGCCACGATCTC
CACGCGCATCACCAACGAATGCCGACAGATCAACCGCGTCGTTCTCGATTGCACGAGCAAGCCTCCGGCCACAATTGAAT
GGGAGTAA

Protein sequence :
MFSPRKIPMNVRGISMANGPVLVVDFGAQYAQLIARRVREAGVYSELVPHSMPVDEILAKDPKAIILSGGPASVFEPGAP
TIDTKVFESGVPVLGICYGFQVMAYELGGKVDKAALGEYGKTSATIDDAAGILADSPAEQTTWMSHGVAVEQAPAGFEVL
AHTEGAPVAAMADESRKLYGVQWHPEVKHSPLGQKLIENFLHRCAALPNDWDASSIIEDQVKKIREQVGDAEVICGLSGG
VDSAVAAALVHKAIGDQLTCVFVDHGLLRKGEVEQVKHDFVAATGIRLITVDAADDFLDALAGVSEPERKRKIIGEKFIR
TFEKAQRQVLEEAGARGKEVKFLVQGTLYPDVVESGGGDGAANIKSHHNVGGLPKDIKFQLIEPLRTLFKDEVRAIGTEL
GLPDEIVWRQPFPGPGLGIRIIGEITKERLDLLREADAIAREELSKAGLDRDIWQCPVVLLADVHSVGVQGDERTYGSPI
VLRPVSSEDAMTADWSRVPYDVLATISTRITNECRQINRVVLDCTSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 7e-166 68
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 4e-136 53
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 4e-136 53
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 5e-136 53