Gene Information

Name : y0525 (y0525)
Accession : NP_667862.1
Strain : Yersinia pestis KIM
Genome accession: NC_004088
Putative virulence/resistance : Virulence
Product : secretion system apparatus protein SsaV
Function : -
COG functional category : U : Intracellular trafficking, secretion and vesicular transport
COG ID : COG4789
EC number : -
Position : 592273 - 594327 bp
Length : 2055 bp
Strand : +
Note : with SsaC forms part of a protein export system across the inner and outer cell membranes; part of the Salmonella pathogenicity island 2; part of the type III secretion system

DNA sequence : 
ATGTTTATGAGTAAGTCAGCACTGGTGCGGGGTTTGACGATGATCACCGCGCGGCAGGATATTTTTTTAGCGGTCATGTT
GCTGGTGGCGGTCTTTATGATGATCCTGCCACTGCCTACGACGATGGTGGATTTACTGATCGCCATCAATCTTGCCTTCT
CCGTCATTCTCTTAATGATCTCGATCTATCTGCGCGATCCTTTGGAGTTCTCCGTCTTCCCGTCATTACTGTTGATCACC
ACCCTTTATCGATTGGCACTGACGATCAGCACCACGCGACTGGTGCTGTTGCAACATGATGCCGGTGAGATTGTCGAGGC
ATTCGGTCAGTTTGTCGTGGGCGGTAATCTGGCCGTCGGGATGATCATTTTTACCATTATCACGGTGGTCCAATTTATCG
TGATTACCAAAGGTTCAGAGCGGGTTGCTGAGGTCAGTGCGCGCTTCTCACTTGATGGTATGCCGGGTAAGCAGATGAGC
ATCGACGGCGACATGCGTGCGGGTGCGATCGATTCGGTCGAAGCTAAACGGCTACGGGAGCGGGTACAAAAAGAGAGCCG
CTTATTTGGTGCTATGGACGGTGCCATGAAGTTTGTTAAAGGGGATGCCATCGCTGGGATCATTGTCATTCTGATCAATA
TCATTGGCGGTATCACTATTGGTGTGATGCAACACAAGATGTCCGCGGAAGAGGCGATGAATACCTACGCGGTATTATCG
ATAGGCGATGGATTGTGCGCCCAAATCCCTTCATTACTGATCTCGATTACCGCCGGGATTATTGTTACCCGGGTTCCTGG
CAGCAACAAACAGAGTCTGGCGAATGAGTTGGCGGTGCAGGTGGGGCGTCAACCGGATGCGCTGTGGTTAGCTGCCGCTA
TTCTGACGGTGTTCGCCCTGTTACCCGGCTTCCCGTTCCTGATCTTTATCACTTTGGCGGCCGCGGTTGCGGCTCCGGCT
TTTTTACTTTATCGGAAGAACCGGCGGATATCGCAGGATGGTCGCGCAAATGGAGGCAGTGAAGAGGGGGGGGCCACGGG
GCAGCGTATGACGCCTGGTGCCGTACCGCTGATGCTGCACTGTGCATCAAATTTACATCACCCGCATTTAGGGCGCGATA
TTGATGGCCTACGCTGGCGCTGGTTTGAGCATCTCGGTGTGCCATTGCCTGAGGTGGAGATCCGCTGTGATCCTACATTG
GCAGAAAATACCTTATCGGTGCAGGTGTATCAGGAGCGGGTGCTGGAGGTTGTGTTACCGCCCGACAGCTTGTTACTGAC
ACGGCCTTGCTCATCGTTAGTAACGAACAATCAGGTATTGGGCGCGAAGATGGGGTCATTTGATTGGCTGGATGCTAAAC
AGGCTATGCAAGCCAGAACCTTGGGTATCCCTTACGTGGAGGGGCATCAGCGGATCATCACCTGTCTGACCAGGGTGTTT
GAACGGTACACCGCCGAATTTATCGGCGTACAGGAGACTCGCTACCTGATGGATGCCATGGAAGGGCGCTATGGTGAGTT
AGTGAAAGAGCTACAACGGCAGATACCCGTCGGTAAAGTGGCTGAAATATTACAACGGCTGGTTGAGGAAAATATTTCCA
TTCGCGATTTACGGACTATTTTCGGCGCGTTGGTGGTTTGGGCACCGAAAGAAAAAGATATCGTGATGCTCACCGAATAT
GTCCGTATCGCCTTGCGCCGTCATTTGTGCCGTCGCTTTAGTCACAATAAAACCTGGATATCAGTATTACGCCTCGGTGA
TGGGGTGGAGCATCTGATCCGCGACTCTATCCGCCAGACATCATCAGGCACTTACTCCGCACTGGAGGAGAGGCAATCCC
TCTTGATCCTCAACAAAATAAAAAACGCATTTGCTGAAAACCAGGATGCGGTATTGCTTACCACCCTCGATGTTCGTCGC
TTTGTCCGCAAAATTATTGAGCGGGATCTCTTCGTGCTACCGGTACTTTCCTGGCAGGAACTGGGCGATGAAATGAATCT
CAAGGTGGCGGGCACCATTGAACTGATTGGCGATGAACTTGATGAAACTGCCTGA

Protein sequence : 
MFMSKSALVRGLTMITARQDIFLAVMLLVAVFMMILPLPTTMVDLLIAINLAFSVILLMISIYLRDPLEFSVFPSLLLIT
TLYRLALTISTTRLVLLQHDAGEIVEAFGQFVVGGNLAVGMIIFTIITVVQFIVITKGSERVAEVSARFSLDGMPGKQMS
IDGDMRAGAIDSVEAKRLRERVQKESRLFGAMDGAMKFVKGDAIAGIIVILINIIGGITIGVMQHKMSAEEAMNTYAVLS
IGDGLCAQIPSLLISITAGIIVTRVPGSNKQSLANELAVQVGRQPDALWLAAAILTVFALLPGFPFLIFITLAAAVAAPA
FLLYRKNRRISQDGRANGGSEEGGATGQRMTPGAVPLMLHCASNLHHPHLGRDIDGLRWRWFEHLGVPLPEVEIRCDPTL
AENTLSVQVYQERVLEVVLPPDSLLLTRPCSSLVTNNQVLGAKMGSFDWLDAKQAMQARTLGIPYVEGHQRIITCLTRVF
ERYTAEFIGVQETRYLMDAMEGRYGELVKELQRQIPVGKVAEILQRLVEENISIRDLRTIFGALVVWAPKEKDIVMLTEY
VRIALRRHLCRRFSHNKTWISVLRLGDGVEHLIRDSIRQTSSGTYSALEERQSLLILNKIKNAFAENQDAVLLTTLDVRR
FVRKIIERDLFVLPVLSWQELGDEMNLKVAGTIELIGDELDETA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
YPO0266 YP_002345347.1 secretion system apparatus protein SsaV Virulence Not named Protein 0.0 100
ssaV NP_456114.1 putative type III secretion protein Virulence SPI-2 Protein 5e-160 58
ssaV NP_805085.1 secretion system apparatus protein SsaV Virulence SPI-2 Protein 5e-160 58
ssaV NP_460379.1 secretion system apparatus protein SsaV Virulence SPI-2 Protein 3e-160 58
ssaV CAA70536.1 secretion system apparatus Virulence SPI-2 Protein 2e-160 58
ssaV YP_216422.1 secretion system apparatus protein SsaV Virulence SPI-2 Protein 3e-160 58
escV YP_003223476.1 translocator EscV Virulence LEE Protein 1e-126 49
escV CAI43875.1 EscV protein Virulence LEE Protein 8e-127 49
escV YP_003232152.1 T3SS structure protein EscV Virulence LEE Protein 6e-127 49
escV AAK26714.1 EscV Virulence LEE Protein 4e-127 49
escV AAL57541.1 EscV Virulence LEE Protein 4e-127 49
escV CAC81861.1 EscV protein Virulence LEE II Protein 4e-127 49
escV YP_003236089.1 putative translocator EscV Virulence LEE Protein 3e-126 49
escV NP_290269.1 hypothetical protein Virulence LEE Protein 2e-125 49
escV AAC31514.1 L0035 Virulence LEE Protein 2e-125 49
ECs4569 NP_312596.1 hypothetical protein Virulence LEE Protein 2e-125 49
escV ACU09459.1 EscV protein Virulence LEE Protein 2e-125 49
escV AAC38382.1 EscV Virulence LEE Protein 7e-126 49
escV AFO66414.1 putative LEE-encoded type III secretion system factor Virulence SESS LEE Protein 4e-121 49
escV AFO66296.1 putative LEE-encoded type III secretion system factor Virulence SESS LEE Protein 4e-121 49
unnamed AAL06368.1 EscV Virulence LEE Protein 5e-124 48
lssD AAO18050.1 LssD Virulence TTSS locus Protein 3e-124 46
invA AAS66860.1 InvA Not tested SSR-2 Protein 6e-88 42
hrcV AAT96193.1 HrcV Virulence T-PAI Protein 3e-92 41
hrcV AAT96139.1 HrcV Virulence T-PAI Protein 3e-92 41
hrcV ABA47273.1 HrcV Virulence S-PAI Protein 3e-89 41
ysaV AAS66840.1 YsaV Not tested SSR-1 Protein 1e-95 41
hrcV NP_791229.1 type III secretion protein HrcV Virulence Hrp PAI Protein 2e-87 41
hrcV AAT96337.1 HrcV Virulence S-PAI Protein 2e-87 41
hrcV AAT96297.1 HrcV Virulence S-PAI Protein 4e-88 41
hrcV AAT96256.1 HrcV Virulence S-PAI Protein 2e-88 41
hrcV AAR25631.1 type III secretion protein HrcV Not tested Not named Protein 8e-84 41
hrcV AAB05999.2 HrcV Virulence Hrp PAI Protein 3e-93 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
y0525 NP_667862.1 secretion system apparatus protein SsaV VFG0514 Protein 1e-160 58
y0525 NP_667862.1 secretion system apparatus protein SsaV VFG0729 Protein 4e-126 49
y0525 NP_667862.1 secretion system apparatus protein SsaV VFG0813 Protein 1e-125 49
y0525 NP_667862.1 secretion system apparatus protein SsaV VFG0064 Protein 1e-127 48
y0525 NP_667862.1 secretion system apparatus protein SsaV VFG0198 Protein 3e-107 45
y0525 NP_667862.1 secretion system apparatus protein SsaV VFG0384 Protein 2e-120 45
y0525 NP_667862.1 secretion system apparatus protein SsaV VFG2126 Protein 5e-97 42