Gene Information

Name : iucD (y3384)
Accession : NP_670683.1
Strain : Yersinia pestis KIM
Genome accession: NC_004088
Putative virulence/resistance : Virulence
Product : lysine: N6-hydroxylase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG3486
EC number : -
Position : 3730087 - 3731415 bp
Length : 1329 bp
Strand : +
Note : aerobactin siderophore biosynthesis; residues 1 to 423 of 442 are 60.28 pct identical to residues 1 to 423 of 445 from GenPept : >gb|AAK71634.1|AF335540_6 (AF335540) IucD [Shigella boydii]

DNA sequence :
ATGAATCAGCCTCTGGATTTCATCGGCATTGGCATCGGCCCATTTAACCTCAGTATTGCCGCACTTGGCAGTGAAGTTTC
TGGCTTTAACAGTAAATTTCTCGAACGTAAACCGCACTTTTCCTGGCACCCTGGCATGATGGTGCCGGACTGCCATATGC
AGACCTGCTTCCTGAAAGACTTGGTCAGCACAGTCTCCCCGACTAACACGTACAGCTTTCTTAACTATCTGGTGCAGCAT
AAGAAATTCTACCGTTTTCTGACCACCGAGCACCGGACCGTTTCCCGTGAGGAGTTTGCGGACTACCTCCGTTGGGCCGC
CAGTGGCATGAGTTCGCTCGAGTTTAGCCAAGATATTCAGAGCGTGGACTTTGACGACCAGCAGCGCCATTTTGTCGTTA
CCACCCCGCGTAATGTCTACCACGCGCGCCACGTTTGCCTGGGGATAGGCAAACGCATCAAATTGCCAGACTGCGTGACC
GAGCAAAATGACCGCTGCTTCCATGCCAGCGAAATGGCACTGCGTAATCCAGATCTGACCGGTAAACGCGTCACCATTGT
GGGCGGCGGCCAGAGCGGGGCGGACCTGTTCCTGAACATCTTTCTCGCTGCATGGGGGCAGCCAAAGCAGCTGAACTGGA
TTTCACGCCGTAACAACTACAACGCGCTGGATGAAGCCGCTTTTGCCAATGAGTACTTCATGCCGGAATACGTTGAGAGT
TTCTACACCCTGAACGACAGCGCCAAACAGCATATGCTGGCAGAACAGAGAATGACCTCTGACGGCATTACCAGTGAATC
ACTACTGGCGATTTACCGTGCTATGTACCACCAATTTGAAGTGTTACATGAAAAACCGTGGGCGCGCCTGCTCCCCAGCC
GCTCACTGACCAATATGCATACGCGCGGCAACGGTTACCAATTACTCACCCATCACCATCTCGATCAAGGCACAGAAACT
TTTGATACCGATGTGGTAATCTTCGCCACGGGTTATCAGCAGGATCGACCGGCGTTTCTCGATCCATTAGCTGATCGTCT
GCAAACCACCGCCGATTGCCAGTACCAAGTGGCTCCAGATTTTGTCCTCGACTGGCAAGGCCCGCGTGAAAACTGCTTGT
TCGCCGTGAATGCCGGTATGCATAGCCACGGCATTGCCGAACCTCAGCTCAGCCTGATGGCTTGGCGATCAGCACATATT
CTCAACCGGGCTTTAGGGCGCACTCAGTTCGATTTAACTTCCACCCCGGCGGTGATCCAATGGCGCAGCCAACAGTCGGG
TGTCCCTGCCCACCCGGAACATCCCGTGCTCAACTGCATCGACATTTAA

Protein sequence :
MNQPLDFIGIGIGPFNLSIAALGSEVSGFNSKFLERKPHFSWHPGMMVPDCHMQTCFLKDLVSTVSPTNTYSFLNYLVQH
KKFYRFLTTEHRTVSREEFADYLRWAASGMSSLEFSQDIQSVDFDDQQRHFVVTTPRNVYHARHVCLGIGKRIKLPDCVT
EQNDRCFHASEMALRNPDLTGKRVTIVGGGQSGADLFLNIFLAAWGQPKQLNWISRRNNYNALDEAAFANEYFMPEYVES
FYTLNDSAKQHMLAEQRMTSDGITSESLLAIYRAMYHQFEVLHEKPWARLLPSRSLTNMHTRGNGYQLLTHHHLDQGTET
FDTDVVIFATGYQQDRPAFLDPLADRLQTTADCQYQVAPDFVLDWQGPRENCLFAVNAGMHSHGIAEPQLSLMAWRSAHI
LNRALGRTQFDLTSTPAVIQWRSQQSGVPAHPEHPVLNCIDI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
iucD AAD44749.1 IucD Virulence SHI-2 Protein 1e-136 60
iucD AAK71634.1 IucD Virulence SHI-3 Protein 5e-137 60
iucD NP_839220.1 lysine:N6-hydroxylase Virulence SHI-2 Protein 2e-136 60
iucD NP_709457.1 lysine:N6-hydroxylase Virulence SHI-2 Protein 2e-136 60
iucD YP_002414043.1 L-lysine 6-monooxygenase Virulence Not named Protein 9e-137 60

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
iucD NP_670683.1 lysine: N6-hydroxylase VFG1084 Protein 3e-137 60
iucD NP_670683.1 lysine: N6-hydroxylase VFG0937 Protein 4e-137 60
iucD NP_670683.1 lysine: N6-hydroxylase VFG0618 Protein 8e-137 60