Gene Information

Name : tpx (y1990)
Accession : NP_669305.2
Strain : Yersinia pestis KIM
Genome accession: NC_004088
Putative virulence/resistance : Virulence
Product : thiol peroxidase
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG2077
EC number : -
Position : 2190007 - 2190510 bp
Length : 504 bp
Strand : -
Note : antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein

DNA sequence : 
ATGACACAGACCGTACATTTCCAAGGCAATCCAGTTTCTGTCGCAGGTAAACTGCCACAAATTGGTGATAAAGCGAAAGA
CTTCACTTTGGTAGCAAAAGATTTATCTGACGTTGCCCTGAGCAGTTTTGCTGGTAAACGCAAAGTCCTGAATATCTTCC
CAAGTATTGATACCGGCGTTTGCGCCGCCTCGGTACGTAAGTTCAATCAACTGGCTGGCGAACTTGAGAACACCGTAGTG
CTTTGTATCTCCTCTGACCTGCCCTTTGCTCAATCACGTTTTTGCGGGGCTGAAGGTCTGAGCAACGTCATCACGCTGTC
AACTCTGCGCGGCGCTGATTTTAAACAAGCTTACGGTGTAGCAATTACTGAAGGCCCTCTGGCAGGTTTGACCGCACGCG
CGGTTGTCGTTCTGGATGGCCAGGACAACGTCATCTACAGCGAATTGGTTAACGAAATCACTACCGAACCAAACTACGAT
GCCGCGCTGGCTGCACTGAAATAA

Protein sequence : 
MTQTVHFQGNPVSVAGKLPQIGDKAKDFTLVAKDLSDVALSSFAGKRKVLNIFPSIDTGVCAASVRKFNQLAGELENTVV
LCISSDLPFAQSRFCGAEGLSNVITLSTLRGADFKQAYGVAITEGPLAGLTARAVVVLDGQDNVIYSELVNEITTEPNYD
AALAALK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tpx YP_001216305.1 thiol peroxidase Not tested VPI-1 Protein 9e-35 49
tpx NP_230472.1 thiol peroxidase Virulence VPI-1 Protein 5e-35 49
tagD AAK20751.1 toxR-activated gene D protein Virulence VPI Protein 6e-35 49
tagD AAK20781.1 toxR-activated gene D protein Virulence VPI Protein 3e-35 49

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tpx NP_669305.2 thiol peroxidase VFG0087 Protein 1e-35 49