Gene Information

Name : y1458 (y1458)
Accession : NP_668778.1
Strain : Yersinia pestis KIM
Genome accession: NC_004088
Putative virulence/resistance : Virulence
Product : acetylneuraminate lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0329
EC number : -
Position : 1616586 - 1617485 bp
Length : 900 bp
Strand : -
Note : residues 3 to 295 of 299 are 75.08 pct identical to residues 1 to 293 of 298 from GenPept : >gb|AAF94925.1| (AE004255) N-acetylneuraminate lyase, [Vibrio cholerae]

DNA sequence : 
ATGCGTATGAAAAAGTTAACCGGCCTGATCGCAGCTCCGCACACTCCCTTTGATGAACAGGGCGAGGTCAATTATCCGGT
CATTGACCAAATTGCCGAGCATCTGATCAATGATGGTGTGAAAGGCGTTTATGTCTGTGGTACCACTGGCGAAGGCATTC
ATTGCTCAGTTGATGAGCGCAAGAAAATTGCTGAACGCTGGGTAAATGCCGCTCAAGGCAAACTGAGCATTACCTTACAC
ACCGGTGCTCTCAGTATTAAAGATGCGGTTGATCTCTCTCCTCATGCGGAAACACTGGATATCTTCGCAACCTCAGCCAT
CGGCCCCTGTTTCTTTAAACCGGGTAATCTGGATGACCTAATCGCTTATTGTCAGGCAATAGCCGCGGCAGCACCGTCGA
AGGGCTTCTATTACTACCACTCCGGTATGTCCGGTGTAAATTTGGACATGGAACAGTTTCTGATCAAAGCGGAATCCAAG
ATCCCTAACTTGTCAGGAATTAAATTCAATAACGCTGATTTGTATGAGTTTCAACGCTGTTTACGTGTGAGTGGCGGTAA
ATTTGATATTCCGTTTGGCGTTGATGAACATCTGCCAGGTGGATTAGCTGTAGGGGCTATTGGCGCTGTTGGCAGCACTT
ATAACTATGCCGCTCCGCTGTTCCATAAAATTATCGCTGACTTTAATGCGGGTGATCAGGTTGCGGTACAGCGTGGAATG
GATCACGTTATCGCCCTGATCCGTGTGCTGGTCGAATTCGGTGGTGTTGCCGCCGGTAAGGCCGCGATGCAATTACATGG
TATTGATGCCGGTAACCCACGTCTGCCACTGCGTGCCTTGACCAAAGAACAGAAGCAAACCGTGGTTAACAGAATGCGTG
ACGCTATTACGTTGCAGTAA

Protein sequence : 
MRMKKLTGLIAAPHTPFDEQGEVNYPVIDQIAEHLINDGVKGVYVCGTTGEGIHCSVDERKKIAERWVNAAQGKLSITLH
TGALSIKDAVDLSPHAETLDIFATSAIGPCFFKPGNLDDLIAYCQAIAAAAPSKGFYYYHSGMSGVNLDMEQFLIKAESK
IPNLSGIKFNNADLYEFQRCLRVSGGKFDIPFGVDEHLPGGLAVGAIGAVGSTYNYAAPLFHKIIADFNAGDQVAVQRGM
DHVIALIRVLVEFGGVAAGKAAMQLHGIDAGNPRLPLRALTKEQKQTVVNRMRDAITLQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
VC1776 NP_231411.1 N-acetylneuraminate lyase Not tested VPI-2 Protein 2e-102 76
VC0395_A1374 YP_001217317.1 dihydrodipicolinate synthetase family protein Not tested VPI-2 Protein 2e-102 76
VPI2_0024c ACA01841.1 dihydrodipicolinate synthase/N-acetylneuraminate lyase Not tested VPI-2 Protein 7e-102 76

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
y1458 NP_668778.1 acetylneuraminate lyase VFG1109 Protein 1e-102 76