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Name : lysS (SpyM3_0420) Accession : NP_664224.1 Strain : Streptococcus pyogenes MGAS315 Genome accession: NC_004070 Putative virulence/resistance : Virulence Product : lysyl-tRNA synthetase Function : - COG functional category : J : Translation, ribosomal structure and biogenesis COG ID : COG1190 EC number : 6.1.1.6 Position : 460078 - 461571 bp Length : 1494 bp Strand : - Note : class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA DNA sequence : ATGTCTAATCAACACATCGAAGAATTAAATGACCAACAGATTGTCCGTCGTGAAAAGATGATGGCTCTGGCTGAACAAGG AATTGATCCTTTCGGTAAACGCTTTGGCCGCACAGCCAATTCTGCTGAATTAAAAGAAAACTATGCTGATAAAACAAAAG AAGAATTACATGAGTTAAACGAAACAGCTATTGTTGCTGGCCGCTTGATGACAAAACGTGGCAAAGGTAAGGTTGGTTTT GCTCATCTTCAAGACCGTGAAGGCCAAATCCAACTTTATGTTCGCAAGGACTCTGTTGGCGAAGACAACTATGAAATCTT CAAAAAAGCCGATTTAGGCGACTTTATCGGCGTTGAAGGCGAAGTCATGCGTACAGACATGGGCGAGTTGTCAATCAAGG CAACCAAGTTGACTCACCTTTCTAAATCACTTCGTCCTCTTCCTGAAAAATTCCACGGATTAACTGATATTGAAACCATT TACCGTAAGCGTCACCTTGATTTAATTTCAAATCGTGAAAGCTTTGACCGCTTCGTGACCCGTTCCAAAATGATTTCAGA AATCCGTCGTTATTTAGACGGTCTTGATTTCCTAGAAGTAGAAACGCCTGTGCTTCATAACGAGGCTGGTGGTGCTGCTG CTCGTCCTTTCGTTACTCACCATAATGCTCAAAACATTGATATGGTGCTTCGTATCGCAACAGAACTTCATTTGAAACGT TTGATTGTTGGTGGTATGGAACGTGTCTATGAAATTGGTCGTATCTTCCGTAACGAGGGAATGGATGCTACTCATAATCC TGAGTTCACTTCTATTGAGGTTTACCAAGCCTATGCAGACTATCTTGATATCATGAACCTGACAGAAGGCATTATCCAAC ATGCTGCTAAAGCTGTTAAAGGTGATGGGCCTATTGATTATCAAGGAACTGAAATCCGTATCAATGAACCTTTCAAACGT GTCCACATGGTAGATGCTATCAAGGAAGTGACAGGTGTTGATTTCTGGCCTGAAATGACTGTCGAAGAAGCTATTGCACT TGCCAAAGAAAAACAGGTCCCACTCGAAAAACACTTCACAAGTGTCGGACATATCATCAATGCTTTCTTCGAAGAATTCG TTGAAGAAACCTTGGTCCAACCAACCTTTGTGTTTGGTCATCCTGTTGAAGTATCGCCTTTGGCTAAGAAGAATCCAGAA GATACCCGCTTCACCGACCGCTTCGAACTTTTCATCATGACCAAAGAATACGCCAATGCTTTCACAGAGTTGAATGATCC CATTGACCAATTATCTCGTTTTGAAGCACAAGCACAAGCCAAAGAACTTGGTGATGACGAAGCAACTGGCATTGACTACG ACTTCGTTGAAGCTCTTGAATATGGTATGCCGCCAACCGGTGGACTCGGAATCGGGATTGATCGTCTTTGCATGTTATTA ACAAACACAACAACAATCAGAGATGTGCTTTTATTCCCAACGATGAAACCTTAA Protein sequence : MSNQHIEELNDQQIVRREKMMALAEQGIDPFGKRFGRTANSAELKENYADKTKEELHELNETAIVAGRLMTKRGKGKVGF AHLQDREGQIQLYVRKDSVGEDNYEIFKKADLGDFIGVEGEVMRTDMGELSIKATKLTHLSKSLRPLPEKFHGLTDIETI YRKRHLDLISNRESFDRFVTRSKMISEIRRYLDGLDFLEVETPVLHNEAGGAAARPFVTHHNAQNIDMVLRIATELHLKR LIVGGMERVYEIGRIFRNEGMDATHNPEFTSIEVYQAYADYLDIMNLTEGIIQHAAKAVKGDGPIDYQGTEIRINEPFKR VHMVDAIKEVTGVDFWPEMTVEEAIALAKEKQVPLEKHFTSVGHIINAFFEEFVEETLVQPTFVFGHPVEVSPLAKKNPE DTRFTDRFELFIMTKEYANAFTELNDPIDQLSRFEAQAQAKELGDDEATGIDYDFVEALEYGMPPTGGLGIGIDRLCMLL TNTTTIRDVLLFPTMKP |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| unnamed | CAD66193.1 | putative lysil-tRNA synthetase LysU | Not tested | PAI III 536 | Protein | 1e-105 | 47 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| lysS | NP_664224.1 | lysyl-tRNA synthetase | VFG1668 | Protein | 8e-106 | 47 |
