Gene Information

Name : smpB (SpyM3_0353)
Accession : NP_664157.1
Strain : Streptococcus pyogenes MGAS315
Genome accession: NC_004070
Putative virulence/resistance : Unknown
Product : SsrA-binding protein
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0691
EC number : -
Position : 393252 - 393719 bp
Length : 468 bp
Strand : +
Note : binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Ca

DNA sequence :
ATGGCAAAAGGTGAAGGTCATATACTGGCGCAAAATAAAAAGGCTAGACATGATTATCACATTGTTGAAACCGTTGAAGC
AGGGATTGTCTTAACGGGAACTGAGATTAAAAGTGTTCGTGCAGCCCGTATTCAACTGAAAGATGGCTTTGCCCAAATTA
AGAATGGGGAAGCGTGGTTGGTCAACGTGCATATTGCACCTTTTGAACAAGGTAATATTTGGAACGCTGATCCTGAACGG
ACCCGCAAACTGTTGCTCAAAAAACGTGAGATTACGCATCTAGAAAATGAACTTAAAGGATCTGGCATGACCTTAGTTCC
TCTCAAAGTTTACCTCAAGGATGGCTTTGCTAAAGTTCTGATTGGTCTAGCTAAAGGGAAACACGAGTATGACAAACGCG
AAACCATTAAACGCCGTGATCAGGAAAGAGATATTAAAAAACAAATGAAACACTACAATGCAAGGTAA

Protein sequence :
MAKGEGHILAQNKKARHDYHIVETVEAGIVLTGTEIKSVRAARIQLKDGFAQIKNGEAWLVNVHIAPFEQGNIWNADPER
TRKLLLKKREITHLENELKGSGMTLVPLKVYLKDGFAKVLIGLAKGKHEYDKRETIKRRDQERDIKKQMKHYNAR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed AET14351.1 SsrA-binding protein Not tested SaPI68111 Protein 1e-37 58
smpB YP_001800894.1 SsrA-binding protein Not tested Not named Protein 8e-35 48