Gene Information

Name : metB (SpyM3_0133)
Accession : NP_663937.1
Strain : Streptococcus pyogenes MGAS315
Genome accession: NC_004070
Putative virulence/resistance : Unknown
Product : cystathionine beta-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : -
Position : 156817 - 158037 bp
Length : 1221 bp
Strand : +
Note : best blastp hit: gb|AAK33272.1| (AE006486) cystathionine beta-lyase [Streptococcus pyogenes M1 GAS]

DNA sequence :
TTGGTTTGTGCAACCATTGGGGTGGGACCATTGTCTAAAAGAGAGTTCATTGGAGTTAACGCTATTGCGGAGGTGCACGA
AATGAGAGAAAATACGACCTTATTACATGGCTATACGGTTATTGACGAGTTTACAGGAGCAGCTTCAGTTCCCATCTATC
AGACTTCGACGTTCCACAATTCAGAACTGTATTGTCCTAGTCAAAAACATTTGTACACACGCTTTTCAAACCCAACGACT
GAAGCTTTAGAAGACGGGTTAGCCTGTTTAGAAAAAGCGACTTATGCGGTGGCTTATGCATCTGGTATGGCTGCTATTTC
AACTGTTTTGATGCTCTTAAAAGCTGGAGATCATGTGATTTTCCCATTGGAGGTCTATGGAGGGACTTGTCAATTTGCGA
CAGCTATTTTACCCAATTATCAGATTGAAACAAGCTTTGTAGATATGGCTGATTTAGCAACAGTAAAAGCAAGTATCAGG
CCTAATACACGTATGATTTATCTAGAGACACCGTCAAATCCGCTCTTGAAAATTTGTGATATTTCAGAGCTTGTGCAACT
CGCCAAAGCTTATGGTGTGCTAACTGTGGCTGATAATACCTTTATGACAAGTTTGTATCAAGAACCCTTAGCTATGGGTG
TGGATATTGTGGTAGAAAGTGTGACAAAATTTATCAATGGTCATAGTGATGTGGTAGCTGGTTTAGCTGCTACCAATAAT
GAGGCTATCTACAACCAGCTCAAGCTTTTTCAAAAAAACTTTGGAGCAATTGTTGGGGTCGAAGACGCTTGGCTGATTCT
TCGTGGCATGAAAACTATGGGGATCCGTATGGAACAAGCGGTAAAAAATGCTCAGCAGCTCGCTAACTATTTAGCGAAGC
ACCCCAAAGTTCTTAAGGTACATTACCCTGGCTTAGACAGTCATCCTAATCACGATACCCACCTGCAACAAGCTAAGAAT
GGTGGTGCTGTTTTATCCTTTGAGTTGGCTTCTAAGGAGGAGCTGATGACCTTTACCCATCGTATTCAGTTGCCGATTTT
AGCCGTTAGTCTAGGTGGAGTAGAGTCCATTTTGTCACATCCAGCAACGATGTCTCATGCTTGTTTATCGTCACAAGCGC
GGTTGGAACAAGGGGTTGTTGATGGTTTGCTGCGCTTGTCTTGTGGTGTTGAAAATATCGAAGACTTATTGGCCGATTTT
GAGCAAGCACTTGCTTTTTAA

Protein sequence :
MVCATIGVGPLSKREFIGVNAIAEVHEMRENTTLLHGYTVIDEFTGAASVPIYQTSTFHNSELYCPSQKHLYTRFSNPTT
EALEDGLACLEKATYAVAYASGMAAISTVLMLLKAGDHVIFPLEVYGGTCQFATAILPNYQIETSFVDMADLATVKASIR
PNTRMIYLETPSNPLLKICDISELVQLAKAYGVLTVADNTFMTSLYQEPLAMGVDIVVESVTKFINGHSDVVAGLAATNN
EAIYNQLKLFQKNFGAIVGVEDAWLILRGMKTMGIRMEQAVKNAQQLANYLAKHPKVLKVHYPGLDSHPNHDTHLQQAKN
GGAVLSFELASKEELMTFTHRIQLPILAVSLGGVESILSHPATMSHACLSSQARLEQGVVDGLLRLSCGVENIEDLLADF
EQALAF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 0.0 99
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 5e-77 43
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-77 43